NF-κB Controls Resistance of Human Salivary Gland (HSG) Cells to Apoptosis in an &amp;lt;i&amp;gt;in Vitro&amp;lt;/i&amp;gt; Model of Sjogren’s Syndrome

Jamal, Syed A.; Torres-Romero, Luis F.; Molteni, Agostino; Shnyra, Alexander; McArthur, Carole

doi:10.4236/ojra.2014.43025

Cited by 1 publication

(2 citation statements)

References 31 publications

(41 reference statements)

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“…Furthermore, resistance to apoptosis would be defective in pSS. 17,42 Our results suggest that IL-10 is not sufficient to resist the level of IL-17A, TNF-α, and IL-6-induced inflammation. Therefore, the balance between proand anti-inflammatory cytokines is unbalanced.…”

Section: Discussionmentioning

confidence: 76%

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A case for IL-6, IL-17A, and nitric oxide in the pathophysiology of Sjögren’s syndrome

Benchabane

Boudjelida

Toumi

et al. 2016

Int J Immunopathol Pharmacol

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Sjögren's syndrome (SS) is an autoimmune epithelitis characterized by mononuclear cell (MNC) infiltration of the lacrimal and salivary glands (SG), as well as the presence of serum autoantibodies. This condition is a growing public health concern in Algeria. Herein, we sought to determine if the levels of interleukin (IL)-6, IL-17A, and nitric oxide (NO), were correlated with the extent of MNC infiltration. The expression of inducible NO synthase (NOS2) and CD68 was measured in the SG of all patients, but not in those of the normal controls (NCs). We included 44 primary Sjögren's syndrome (pSS) patients and 15 NCs in this study; we found that the expression of NOS2 and CD68 was elevated in all of the SG of SS patients. Additionally, the serum and saliva levels of IL-6, IL-17A, and NO were higher in the pSS patients, compared with the NCs. Furthermore, the NOS2-induced excess NO was associated with the extent of the MNC infiltration, and thereby with tissue injury. It is also important to note that there were correlations between the levels of IL-6, IL-17A, and NO. Such findings indicate that through the effects of NO, IL-17A participates in the pathophysiology of the disease. With the purpose of improving both the diagnosis and prognosis, IL-6, IL-17A, and NO should be assayed in the serum and saliva of patients suspected of SS.

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Section: Discussionmentioning

confidence: 76%

“…NO has an immunoregulatory effect and, as a result, governs the function of the SG. [15][16][17] Interestingly, NO overproduction has also been seen in hydatidosis, 18 Behçet's disease, 19 periodontitis, 20 and inflammatory bowel diseases. 21 In MØ, NO is synthesized by NOS2 22,23 following TLR stimulation (e.g.…”

Section: Introductionmentioning

confidence: 99%