NF-κB inhibitory and cytotoxic activities of hexacyclic triterpene acid constituents from Glechoma longituba

Insight into the Potential of Meehania fargesii var. Radicans against Hp‐Induced Gastric Carcinoma Based on Phytochemical and Molecular Docking Studies

“…Besides MFR, 1 – 2 , 4 , 8 and 12 were also isolated from Glechoma longituba , [6] provided chemotaxonomic evidence for a close phylogenetic relationship between the genera Meehania and Glechoma in Lamiaceae family [3] . In addition, 1 – 8 and 12 were isolated from Prunella vulgaris , 1 , 3 – 8 , 10 and 12 were obtained from many plants of the genus Salvia , 1 – 8 and 10 were found in several species in genus Isodon .…”

“…The compounds were identified as 2 α ,3 α ,24‐trihydroxyurs‐12‐en‐28‐oic acid ( 1 ), [6] 2 α ,3 α ,24‐trihydroxyolean‐12‐en‐28‐oic acid ( 2 ), [7] 2 α ,3 α ,23‐trihydroxyolean‐12‐en‐28‐oic acid ( 3 ), [8] 2 α ,3 α ,23‐trihydroxyurs‐12‐en‐28‐oic acid ( 4 ), [9] asiatic acid ( 5 ), [10] tormentic acid ( 6 ), [11] arjunolic acid ( 7 ), [12] euscaphic acid ( 8 ), [13] ( Z , E )‐2‐(3,5‐dihydroxyphenyl)ethenyl ester ( 9 ), [14] ( Z , E )‐2‐(3,4‐dihydroxyphenyl)ethenyl ester ( 10 ), [15] Acacetin 7‐ O ‐ β ‐D‐glucopyranosyl‐(1→2)‐[α‐L‐rhamnopyranosyl‐(1→6)]‐ β ‐D‐glucopyranoside ( 11 ), [16] Linarin ( 12 ) [17] . All of them were isolated from MFR for the first time, while 1 – 9 and 11 – 12 were obtained from the genus of Meehania for the first time.…”

Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway

“…However, the oleane-type triterpene acid contains a methyl group at C-14, but the methyl group was replaced with a methylene group [δ C 15.8, δ H 1.03 (br d, J = 4.0 Hz), 1.29 (o), CH 2 -27) in compound 1 . In addition, correlations of H 2 -27/C-12, C-13, C-14, and C-15 were also observed in the HMBC spectrum, indicating the formation of a cyclopropane ring among C-13/C-14/C-27. , Thus, the planar structure of compound 1 was established as 2,3,16-trihydroxy-13,27-cycloolean-11-en-28-oic acid. The NOESY spectrum (Figure B) indicates that H-2, H-3, H-18, Me-24, Me-25, and Me-30 are β-oriented, while H-5, H-8, H-16, Me-23, H 2 -27, and Me-29 are α-oriented.…”

“…Furthermore, the 1 H− 1 H COSY correlations (Figure 4A), together with the key HMBC correlations (Figure 4A), were also observed in the HMBC spectrum, indicating the formation of a cyclopropane ring among C-13/C-14/C-27. 23,24 Thus, the planar structure of compound 1 was established as 2,3,16-trihydroxy-13,27-cycloolean-11-en-28-oic acid. The NOESY spectrum (Figure 4B) indicates that H-2, H-3, H- +21.3 (c 0.6, MeOH).…”

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

“…It has been reported that phlomisoside F, a diterpene glycoside isolated from Phlomis younghusbandii root, promotes G0/G1 cell cycle delay and apoptosis induction, as confirmed by the overexpression of caspase-3, caspase-9, and Bax, and the underexpression of Bcl-2 and COX-2 in A549 cells [ 278 ]. 2α, 3α, 23-trihydroxy-13α, 27-cyclours-11-en-28-oic acid, a triterpene acid isolated from the aerial parts of Glechoma longituba , is responsible for NCI-H460 cell cycle arrest, the induction of ROS-mediated apoptosis, and the nullification of NF-κB activity [ 279 ]. The exposure of human lung cancer cell line SK-LU-1 cells to pogostemin A, a meroterpenoid isolated from the aerial parts of Pogostemon auricularius , triggered apoptosis and caspase-3 activation [ 280 ].…”