NF‐κB nuclear localization and its prognostic significance in prostate cancer

Abstract

RESULTSThe NF-k B subcellular localization was initially assessed in 45 specimens; in these samples a nuclear localization of NF-k B was specific to cancer tissues, but did not correlate with the Gleason score ( P = 0.089). NF-k B was then assessed as a prognostic marker to complement Gleason score in predicting cancer progression. Tumour tissues from 30 men with a known clinical outcome were included; 10 of 17 patients who had a poor outcome were positive for NF-k B nuclear staining, whereas only two of 13 with a good outcome were positive ( P = 0.026). When NFk B subcellular localization and Gleason score were combined, two risk categories of progression were defined. Eleven of 13 specimens from those with a good outcome were in the low-risk category (Gleason 2-4 or Gleason 5-7 with negative nuclear NF-k B)

Activation of nuclear factor-κB in human prostate carcinogenesis and association to biochemical relapse

“…In another study, nuclear NF-kB was found in 40% of prostate tumours in 40 specimens assayed (Lessard et al, 2003). As in the current study, nuclear NF-kB did not significantly correlate with Gleason score.…”

“…As in the current study, nuclear NF-kB did not significantly correlate with Gleason score. In a highly selected series of 30 patients, nuclear localisation was significantly associated with the prognostic groups (Lessard et al, 2003). Multivariate analysis was not reported in that study.…”

“…undetected nuclear NF-kB, low PSA and low Gleason) were free of biochemical recurrence. A prior study with 30 patients that combined nuclear staining with Gleason grade also improved prediction of clinical outcome (Lessard et al, 2003). These observations merit further analysis in prospective studies given its potential interest in adjuvant management strategies of patients with PAC that undergo prostatectomy.…”

“…Along this line, several preclinical observations have shown that NF-kB plays a role in prostate cancer growth, survival, angiogenesis and metastatic progression (Muenchen et al, 2000;Yu et al, 2000;Catz and Johnson, 2001;Huang et al, 2001;Gasparian et al, 2002;Gunawardena et al, 2002;Gupta et al, 2002;Suh et al, 2002;Zerbini et al, 2003;Suh and Rabson, 2004). Furthermore, emerging data obtained from human studies also suggest a potential role of NF-kB in prostate cancer tumorigenesis and/or in its behaviour in a clinical setting (Suh et al, 2002;Lessard et al, 2003;Fradet et al, 2004;Ismail et al, 2004;Ross et al, 2004). In particular, a recent study showed that total overexpression of p65, the best characterised NF-kB protein, was an independent predictor of poor prognosis in prostate cancer patients (Ross et al, 2004).…”

Anticancer Activity of Acanthopanax trifoliatus (L) Merr Extracts is Associated with Inhibition of NF-κB Activity and Decreased Erk1/2 and Akt Phosphorylation

“…NF-kB can regulate of proliferation and apoptosis in a variety of cells including prostate cancer cells (Paule et al, 2007;Karin, 2009;Sambantham et al, 2013). Moreover, NF-kB is commonly activated in invasive prostate cancer (Lessard et al, 2003;Ross et al, 2004;Shukla et al, 2004) and of NF-kB-responsive genes are commonly associated with prostate cancer progression (Shukla et al, 2004). Thus, NF-kB provides an attractive therapeutic target for the treatment of prostate cancer.…”