2019
DOI: 10.3389/fimmu.2019.00815
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NFκB and Kidney Injury

Abstract: The global burden of chronic kidney disease will increase during the next century. As NFκB, first described more than 30 years ago, plays a major role in immune and non-immune-mediated diseases and in inflammatory and metabolic disorders, this review article summarizes current knowledge on the role of NFκB in in vivo kidney injury and describes the new and so far not completely understood crosstalk between canonical and non-canonical NFκB pathways in T-lymphocyte activation in renal dise… Show more

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Cited by 93 publications
(70 citation statements)
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References 164 publications
(164 reference statements)
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“…NF-κB activity has additionally been linked to acute kidney injury (AKI), which is clinically relevant because AKI often contributes to the onset of more severe CKD. Studies on NF-κB and AKI report that NF-κB inhibitors reduce AKI severity, even following the start of injury [60,61]. NF-κB inhibition has also been shown to reduce inflammatory responses and fibrosis in various CKD models, further confirming the importance of NF-κB as a renal inflammation mediator [62,63].…”
Section: Nf-κb and Renal Inflammationmentioning
confidence: 88%
“…NF-κB activity has additionally been linked to acute kidney injury (AKI), which is clinically relevant because AKI often contributes to the onset of more severe CKD. Studies on NF-κB and AKI report that NF-κB inhibitors reduce AKI severity, even following the start of injury [60,61]. NF-κB inhibition has also been shown to reduce inflammatory responses and fibrosis in various CKD models, further confirming the importance of NF-κB as a renal inflammation mediator [62,63].…”
Section: Nf-κb and Renal Inflammationmentioning
confidence: 88%
“…NF-κB (nuclear factor-kappa B) is a ubiquitous transcription factor that modulates the expression of chemokines, cytokines, and adhesion molecules. Inhibition of NF-κB has been addressed through the use of molecules that target receptors, upstream activating kinases, protein degradation, adapter molecules, nuclear translocation, and DNA binding [246]. Numerous studies focus on the potential beneficial effects of NF-κB inhibition on the pathophysiological processes associated with DN [247].…”
Section: Nuclear Factor-κbmentioning
confidence: 99%
“…Acute kidney injury (AKI) is a nephrotic syndrome with a rapid decline in glomerular filtration, which may mostly induced by sepsis, ischemia–reperfusion injury, and nephrotoxic drugs (Song, Thaiss, & Guo, ). In recent years, the morbidity and mortality of AKI are increasing year by year (Hoste et al, ), among which the incidence rates of AKI are 21.6% in adults and 33.7% in children, and the mortality rates are 23.9% in adults and 13.8% in children (Susantitaphong et al, ), affecting public health costs worldwide (Gonsalez et al, ).…”
Section: Introductionmentioning
confidence: 99%