NFκB1 and NFκBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population

Song, Shunxin; Chen, Dianke; Lü, Jiachun; Liao, Jiawei; Luo, Yanxin; Yang, Zhaohui; Fu, Xiaohong; Fan, Xinjuan; Wei, Yisheng; Yang, Lei; Wang, Lei; Wang, Jianping

doi:10.1371/journal.pone.0021726

Cited by 60 publications

(37 citation statements)

References 49 publications

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“…Combining multiple variants may result in greater predictive power of disease risk. Song et al [39] have found that combined genotype of ins/ins+del/ins and GG was associated with an increased risk of sporadic cancer, and as shown in the previously published research, ins/ins/AG combine genotype has a protective role on another inflammatory disease, Hashimoto thyroiditis [27]. On the contrary, according to the multiple comparisons of combined genotypes of rs28362491 and rs696, ins/ins/AA combined genotype frequency was significantly higher in patients with BD than in control groups in this study.…”

Section: Discussionmentioning

confidence: 99%

Association of NFKB1 and NFKBIA Polymorphisms in Relation to Susceptibility of Behçet's Disease

et al. 2014

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Behc ßet's disease (BD) is a chronic inflammatory autoimmune disease. Although raised levels of proinflammatory cytokines in BD have been reported, the pathogenesis is still unknown. The aim of this study was to investigate the association of NFKB1 and NFKBIA polymorphisms and their single and combined analysis effects on susceptibility of BD in Turkish population. We analysed the distribution of NFKB1 -94 ins/del ATTG (rs28362491) and NFKBIA 3 0 UTR A?G (rs696) polymorphisms using PCR-RFLP method in 89 patients with BD and 190 controls in this population. Statistical analysis of the results was performed by calculating OR, and 95% CI via v 2 test and using Bonferroni correction. According to the significant results of both single and combined genotype analysis, the frequencies of ins/ins genotype and ins allele of rs28362491 were significantly higher in patients with BD (Pc = 0.003, 0.004, respectively). Also, higher frequencies of the rs696 variant containing AA genotype was found in patients with BD (Pc = 0.0033), whereas no statistical significant differences in distribution of the alleles of rs696 polymorphism in patients and controls. In addition, according to the combined genotype analysis, the wild type of both rs28362491 and rs696 polymorphisms (ins/ins/AA genotype) was also significantly higher in BD cases (Pc = 0.044). Our findings prove that both single and combined genotype analysis of rs28362491 and rs696 polymorphisms indicate that the wild genotypes of both two SNPs (ins/ins and AA genotypes) and ins/ins/AA combined genotype are strongly associated with enhanced risk of BD in a Turkish population.

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Section: Discussionmentioning

confidence: 99%

Association of NFKB1 and NFKBIA Polymorphisms in Relation to Susceptibility of Behçet's Disease

et al. 2014

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“…Ins allele was reported to increase the risk of oral cancer,31 melanoma,32 prostate cancer,16 gastric cancer,17 nasopharyngeal carcinoma33 and cervical cancer 34. Two studies in European population found that del allele might increase the risk of colorectal cancer,35 36 while in Chinese population, none or even reverse association was obtained 35 37. The difference of polymorphisms may probably result from interactions or combined effects with non-genetic risk factors.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism ofNFKB1andNFKBIAgenes and liver cancer risk: a nested case–control study in Shanghai, China

Gao

et al. 2014

BMJ Open

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ObjectivesGenetic variations of nuclear factor-κB (NF-κB) signalling pathway were found to be associated with inflammatory diseases and several malignancies. However, little is known about NF-κB pathway gene polymorphisms and susceptibility of liver cancer. The aim of this study was to investigate whether genetic variants of NFKB1 and NFKBIA were associated with risk of liver cancer in a Chinese population.DesignThe study was designed as a nested case–control study within two prospective cohorts (the Shanghai Women's Health Study, SWHS, 1996–2000 and the Shanghai Men's Health Study, SMHS, 2002–2006).SettingsThis population-based study was conducted in urban Shanghai, China.ParticipantsA total of 217 incident liver cancer cases diagnosed through 31 December 2009 and 427 healthy controls matched by sex, age at baseline (±2 years) and date (±30 days) of sample collection were included in the study.Primary and secondary outcome measuresGenetic polymorphisms of NFKB1 and NFKBIA were determined blindly by TaqMan single-nucleotide polymorphism (SNP) genotyping assay. OR and its 95% CIs were estimated by an unconditional logistic regression model to measure the association between selected SNPs and the risk of liver cancer.ResultsAfter adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26). Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model. No association was observed between NFKBIA variants and risk of live cancer.ConclusionsOur results suggest that genetic variants of NFKB1 influence liver cancer susceptibility in Chinese population, although replication in other studies is needed.

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“…Combining multiple variants may result in greater predictive power of disease risk. Song et al have stated that combined genotype of ins/ins+del/ins and GG was associated with the risk of sporadic cancer and as shown in previously published research, ins/ins+AG combined genotype and also ins allele frequencies were higher in BD patients considerably [84]. (51) 61 (41) 12 (8) 98 (70) 31 (21) 12 (9) 0.001 rs7527192 60 (40) 81 (54) 9 (6) 75 (53) 62 (44) 4 (3) 0.042 rs2793378 60 (40) 65 (43) 25 (17) 62 (44) 62 (44) 17 (12) >0.05 rs28362491 50 (27) 113 (69) 27 (14) 26 (22) 76 (63) 18 ( Behcet's Disease rs28362491 50 (27) 113 (59) 27 (14) 43 (48) 38 (43) 8 (9) 0.003 rs696 25 (14) 130 (68) 34 (18) 18 (20) 38 (43) 33 ( Table 2: Allele assessment of SNPs rs1136410, rs7527192, rs2793378, rs28362491, and rs696 in PARP-1 and NFKB1 genes in autoimmune diseases in Turkish population.…”

Section: Behçet's Diseasementioning

confidence: 68%

A General Sight about Linking PARP-1 and NFKB1 Variations to the Inflammatory Events

Gk¹,

Yenmiş²,

Koc³

2014

Interdiscip J Microinflammation

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Poly (ADP-ribose) polymerase-1 (PARP-1) has various roles in cellular processes such as DNA repair, genomic stability, transcription, stress response, and cell death via regulating death and inflammation signalling pathways. On the other hand, PARP-1 inhibition has been shown to provide benefits in experimental models of animals with inflammatory diseases such as asthma, atherosclerosis and diabetes. PARP-1 also acts a transcriptional coactivator of nuclear factor kappa B (NFKB). The NFKB is a ubiquitous transcription factor that controls the expression of genes encoding cell adhesion molecules, growth factors, cytokines, and some acute phase proteins. Inappropriate activation of NFKB has been mostly searched with inflammatory events. In complete and persistent inhibition studies of NFKB, apoptosis, inappropriate immune cell development and delayed cell growth were investigated. These findings might provide new perceptions in the pathogenesis of inflammatory disorders regarding the roles of PARP-1 and NFKB1 proteins. In this review, we focus on some variations (rs28362491, rs696, rs1136410, rs2793378, rs7527192) of PARP-1 and NFKB1 genes in relation to susceptibility to common inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, allergic rhinitis, Graves' disease, Hashimoto's thyroiditis, asthma and Behcet's disease.

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NFκB1 and NFκBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population

Cited by 60 publications

References 49 publications

Association of NFKB1 and NFKBIA Polymorphisms in Relation to Susceptibility of Behçet's Disease

Association of NFKB1 and NFKBIA Polymorphisms in Relation to Susceptibility of Behçet's Disease

Genetic polymorphism ofNFKB1andNFKBIAgenes and liver cancer risk: a nested case–control study in Shanghai, China

A General Sight about Linking PARP-1 and NFKB1 Variations to the Inflammatory Events

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