NGAL and NT-proBNP levels in diabetic patients with macroproteinuria

Taşkapan, Hülya; Taşkapan, Mehmet Çağatay; Orman, Ibrahim; Ulutaş, Özkan; Yiğit, Ali; Özyalın, Fatma; Yoloğlu, Saim

doi:10.3109/0886022x.2013.824336

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…The degree of correlation between NGAL and NT-proBNP in the present study (r = 0.56) was higher than that reported by Okuyama et al (r = 0.37) [18] and Yndestad et al (r = 0.15) [22]. Conversely, Taskapan et al [27] and Soren Lindberg et al [28] found no association between either serum or urinary NGAL levels and NT-proBNP. The AUC values of NGAL (0.829) and NT-proBNP (0.792) in the present study were higher than reported previously (AUC = 0.700-0.755 for NGAL and 0.645-0.787 for NT-proBNP) [10], [20], [26].…”

Section: (Percentages In Brackets) Of Patients With High Nt-probnp Co...contrasting

confidence: 73%

The Role of Neutrophil Gelatinase-Associated Lipocalin and N-Terminal Pro B-Type Natriuretic Peptide in the Prediction of Heart Failure in Patients with Acute Coronary Syndrome

Tran

Tran²,

Nguyen³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Heart failure, where the heart cannot pump blood effectively, significantly affects patient quality of life and impacts national health-care services. Acute coronary syndrome is a common underlying cause of acute heart failure. Neutrophil gelatinase-binding lipocalin (NGAL) and N-terminal pro B-type natriuretic peptide (NT-proBNP) are biomarkers released during myocardial injury. Thus, the measured levels of these chemicals may be associated with heart failure events in patients with acute coronary syndrome. AIM: The present study determined the serum levels and measured increases in NGAL and NT-proBNP, as well as recorded heart failure events in patients with acute coronary syndrome in Vietnam. METHODS: A descriptive cross-sectional method was used to recruit 58 patients with acute coronary syndrome and assess the degree to which the two markers could predict ejection fraction (EF). RESULTS: The median values of NGAL and NT-proBNP concentrations in the group with EF ≥40% (7.14 ng/mL and 952.00 pg/mL) were significantly lower than those with EF <40% (166.10 ng/mL and 27,498.00 pg/mL). NGAL was used to predict heart failure events at a threshold of 94.86 ng/mL with a sensitivity of 83.3%, a specificity of 90.4%, and an area under the curve (AUC) of 0.83. Similarly, NT-proBNP predicted heart failure events at a threshold of 8660.5 pg/mL with a sensitivity of 83.3%, a specificity of 84.6%, and an AUC of 0.79. CONCLUSIONS: Serum NGAL and NT-proBNP levels can be used as reliable biomarkers for predicting heart failure events in patients with acute coronary syndrome.

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Section: (Percentages In Brackets) Of Patients With High Nt-probnp Co...contrasting

confidence: 73%

The Role of Neutrophil Gelatinase-Associated Lipocalin and N-Terminal Pro B-Type Natriuretic Peptide in the Prediction of Heart Failure in Patients with Acute Coronary Syndrome

Tran

Tran²,

Nguyen³

et al. 2022

Open Access Maced J Med Sci

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“…Since it was reported by previous studies that serum albumin was inversely associated with urinary albumin level [31][32][33], ACR was additionally included in the multivariate linear regression model for adjustment. The results revealed that the associations of serum albumin with the composite Z scores of CV (b = 0.197, P \ 0.001), amplitude (b = 0.161, P = 0.004), and latency (b = -0.177, P = 0.003) remained significant ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

Serum albumin is associated with peripheral nerve function in patients with type 2 diabetes

Liu

et al. 2015

Endocrine

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The aim of this study is to investigate the association between serum albumin concentrations and nerve conduction (NC) parameters in Chinese patients with type 2 diabetes (T2DM). A total of 409 T2DM patients were enrolled between October 2010 and April 2014. All participants underwent nerve conduction studies. The composite Z scores for NC parameters including conduction velocity (CV), amplitude, and latency were calculated as well. Serum albumin was measured by Bromcresol Green dye-binding method. The composite Z scores of CV and amplitude increased with the increasing albumin tertiles (test for trend, both P < 0.001), while the composite Z score of latency decreased with increasing albumin tertiles (test for trend, P < 0.001). After adjusting for age, sex, duration, and HbA1c, higher serum albumin concentrations were associated with higher composite Z scores of CV (β = 0.314, P < 0.001), amplitude (β = 0.279, P < 0.001), and lower composite Z score of latency (β = -0.279, P < 0.001). When participants were stratified into albuminuria and normoalbuminuria group, we found the associations of serum albumin with composite Z scores of NC parameters remained significant only in the albuminuria group (CV Z score: β = 0.253, P = 0.002; amplitude Z score: β = 0.233, P = 0.006; latency Z score: β = -0.217 P = 0.013) after further adjustment for urinary albumin to creatinine ratio. The optimal cutoff point of serum albumin to indicate abnormal peripheral nerve function was 36.75 g/L in T2DM patients with albuminuria, with a sensitivity of 65.6 % and a specificity of 78.0 %. Serum albumin was independently associated with peripheral nerve function in T2DM patients, especially in those with albuminuria. Serum albumin could be a potential biomarker for diabetic peripheral neuropathy.

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“…In addition, residual renal function, degree of proteinuria, colorectal cancer, hyperuricemia may be associated with increased NGAL levels. [27][28][29][30] We did not investigate these situations. These are limitations of our study.…”

Section: Discussionmentioning

confidence: 99%

Can serum NGAL levels be used as an inflammation marker on hemodialysis patients with permanent catheter?

et al. 2014

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NGAL and NT-proBNP levels in diabetic patients with macroproteinuria

Cited by 8 publications

References 29 publications

The Role of Neutrophil Gelatinase-Associated Lipocalin and N-Terminal Pro B-Type Natriuretic Peptide in the Prediction of Heart Failure in Patients with Acute Coronary Syndrome

The Role of Neutrophil Gelatinase-Associated Lipocalin and N-Terminal Pro B-Type Natriuretic Peptide in the Prediction of Heart Failure in Patients with Acute Coronary Syndrome

Serum albumin is associated with peripheral nerve function in patients with type 2 diabetes

Can serum NGAL levels be used as an inflammation marker on hemodialysis patients with permanent catheter?

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