NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

Schreinlechner, Michael; Noflatscher, Maria; Lener, Daniela; Bauer, Axel; Kirchmair, Rudolf; Marschang, Peter; Theurl, Markus

doi:10.3390/jcm9092811

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…In our study, hs-CRP showed no significant correlation with baseline plaque volume. This has also been shown in a previous publication [ 22 ].…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, the presence of chronic kidney disease and male sex is associated with higher plaque volume [ 21 ]. The biomarker neutrophil gelatinase-associated lipocalin, but not hsCRP was shown to correlate with peripheral plaque volume at baseline [ 22 ]. The purpose of our study was to evaluate the effect of cardiovascular biomarkers, in particular fetuin-A and hsCRP, on atherosclerotic plaque progression.…”

Section: Introductionmentioning

confidence: 99%

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High baseline fetuin-A levels are associated with lower atherosclerotic plaque progression as measured by 3D ultrasound

Sommer¹,

Schreinlechner²,

Noflatscher³

et al. 2021

Atherosclerosis Plus

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“…In our study, hs-CRP showed no significant correlation with baseline plaque volume. This has also been shown in a previous publication [ 22 ].…”

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

High baseline fetuin-A levels are associated with lower atherosclerotic plaque progression as measured by 3D ultrasound

Sommer¹,

Schreinlechner²,

Noflatscher³

et al. 2021

Atherosclerosis Plus

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“…Therefore, it seems that NGAL could be an encouraging inflammatory biomarker to predict cases with asymptomatic atherosclerosis. 131 …”

Section: Inflammatory Biomarkers In Atherosclerosismentioning

confidence: 99%

Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

Hong

Xue

Shao

2021

JIR

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Several lines of evidence have linked a dysregulated inflammatory setting to the pathogenesis of atherosclerosis, which is a form of chronic vascular inflammation. Various inflammatory biomarkers have been associated with inflammation and are recognized as potential tools to monitor the progression of atherosclerosis. A well-studied inflammatory marker in the context of cardiovascular diseases is C-reactive protein (CRP) or, more accurately, highly sensitive-CRP (hs-CRP), which has been established as an inflammatory biomarker for atherosclerotic events. In addition, a growing body of investigations has attempted to disclose the potential of inflammatory cytokines, enzymes, and genetic polymorphisms related to innate and adaptive immunity as biomarkers for predicting the development of atherosclerosis. In this review article, we clarify both traditional and novel inflammatory biomarkers related to components of the innate and adaptive immune system that may mirror the progression or phases of atherosclerotic inflammation/lesions. Furthermore, the contribution of the inflammatory biomarkers in developing potential therapeutics against atherosclerotic treatment will be discussed.

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“…The chi-square test was used to compare categorical variables. Total PV was divided into high (501-2048 mm 3 ) and low (0-500 mm 3 ) total PV, with the 75th percentile as the cut-off point for some calculations, as described previously [34].…”

Section: Discussionmentioning

confidence: 99%

Inverse Correlation of Cholesterol Efflux Capacity with Peripheral Plaque Volume Measured by 3D Ultrasound

et al. 2023

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Introduction: Cardiovascular disease (CVD) is a systemic multifocal illness called atherosclerosis that causes artery constriction and blockage. By causing cholesterol to build up in the artery wall, hypercholesterolemia is a major factor in the pathophysiology of atherosclerotic plaque development. Reverse cholesterol transport is the process of transporting cholesterol from the periphery back to the liver through cholesterol efflux mediated by high-density lipoprotein (HDL). It was suggested that the cholesterol efflux capacity (CEC), which is inversely linked with cardiovascular risk, can serve as a stand-in measure for reverse cholesterol transport. In this work, we sought to investigate a potential link between the peripheral plaque volume (PV) and CEC. Methods: Since lipid-lowering therapy interferes with CEC, we performed a cross-sectional study of 176 patients (48.9% females) with one cardiovascular risk factor or known CVD that did not currently take lipid-lowering medication. CEC was determined using cAMP-treated 3H-cholesterol-labeled J774 cells. Cholesterol ester transfer protein (CETP)-mediated cholesterol ester transfer was measured by quantifying the transfer of cholesterol ester from radiolabeled exogenous HDL cholesterol to Apolipoprotein B-containing lipoproteins. PV in the carotid and the femoral artery, defined as the total PV, was measured using a 3D ultrasound system equipped with semi-automatic software. Results: In our patients, we discovered an inverse relationship between high total PV and CEC (p = 0.027). However, there was no connection between total PV and low-density lipoprotein cholesterol, lipoprotein (a), or CETP-mediated cholesterol ester transfer. Conclusion: In patients not receiving lipid-lowering treatment, CEC inversely correlates with peripheral atherosclerosis, supporting its role in the pathophysiology of atherosclerosis.

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NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

Cited by 6 publications

References 31 publications

High baseline fetuin-A levels are associated with lower atherosclerotic plaque progression as measured by 3D ultrasound

High baseline fetuin-A levels are associated with lower atherosclerotic plaque progression as measured by 3D ultrasound

Inflammatory Markers Related to Innate and Adaptive Immunity in Atherosclerosis: Implications for Disease Prediction and Prospective Therapeutics

Inverse Correlation of Cholesterol Efflux Capacity with Peripheral Plaque Volume Measured by 3D Ultrasound

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