The ability to produce single cell detritus (SCD) from different seaweed species, red seaweed, Gracillaria tenuistipitata and green seaweed, Enteromorpha sp. was determined, and the effects of selected SCD diet on survival rate, growth performance and reproductive characteristics of Artemia franciscana were assessed under laboratory conditions. Experiment 1 included 8 treatments with red and green seaweeds, combined with yeast fermentation at different densities (0, 10 4 , 10 5 , 10 6 cells/mL). The results showed that the density of SCD reached highest at day 7 in the treatments added 10 6 yeast cells/mL (88.480±2.769×10 6 and 100.752±2.687×10 6 cells/mL of red and green seaweeds, respectively). Although the density of SCD was highest at 10 6 yeast cells/mL, the yeast density and NH 4 + concentration in green seaweed fermentation were high (5-10 mg/L). Thus, the treatment of red seaweed and 10 5 yeast cells/mL obtained the suitable ability to harvest at day 7 and preserve SCD for feeding Artemia. In experiment 2, Artemia were fed with 5 different diets, and each diet has three replications. Commercial feed No. 0 (for shrimp postlarvae) was the control, and 4 diets in which the shrimp feed was replaced by SCD with proportion of 100, 75, 50 and 25%. Results showed that diet with 50% shrimp feed and 50% SCD showed the high survival rate and good growth performance, as well as positive effects on the reproductive characteristics of Artemia franciscana.