NHC-Catalyzed Synthesis of Benzazole-Phosphine Ligands under an Air Atmosphere

Abstract

An efficient strategy for the synthesis of benzazole-phosphine ligand precursors via N-heterocyclic carbene catalyzed aerobic oxidative cyclization reaction has been performed. The reaction displays broad functional group tolerance and high atom economy, and the transformation has been further applied to benzazole-phosphine ligand synthesis.

One-pot synthesis of phosphorylnaphth[2,1-d]oxazoles and products as P,N-ligands in C–N and C–C formation

“…1 These ligands have been designed to control the steric and electronic properties of metal complexes by chelation and, in some cases, by use of their hemilability. 2 Among them, phosphinooxazolines, named PHOX (Fig. 1a), is an important class of P,N-ligands consisting of triarylphosphine and oxazoline units connected by a flexible single bond.…”