Ni(II), Cu(II) and Pd(II) Complexes of Anisaldehyde-4-phenyl-thiosemicarbazone: Synthesis, Spectral Characterization and Biological Study

Abstract

Anisaldehyde-4-phenyl-thiosemicarbazone (HL) complexes of Ni(II), Cu(II) and Pd(II) have been synthesized. Conductivity measurements, spectroscopic (FTIR, UV-visible, ESI(+) mass, 13 C and 1 H NMR, ESR), cyclic voltammetry study and thermal analyses were used to propose their molecular formulations. Ni(II), Cu(II) and Pd(II) complexes show room temperature magnetic moments of 3.07, 1.59 and 0.00 BM, respectively. The ligand and the metal complexes have been screened in vitro for antibacterial activity against the bacterial strains viz. P. vulgaris, S. aureus, E. coli, S. aeruginosa, B. subtillis and S. epidemidis and for antifungal activity against the fungal strains viz. A. niger, F. Oxosporum ciceri, F. oxosporum NCIM1281 and R. solani. The ligand, Cu(II) and Pd(II) complexes have been tested for antitubercular activity against Mycobacterium tuberculosis H37RV strain and for anticancer activity against three human cancer lines. The Cu(II) complex was found to be most potent against M. tuberculosis H37RV strain and showed its MIC as 10 µM. The ligand and Cu(II) complex exhibited quite good growth inhibitory activity against most of the tested bacterial and fungal strains.

Synthesis and Characterization of Palladium(II) Complexes with Thiosemicarbazones

“…The broad band at 611 nm in the UV-visible spectrum of complex 3 could be assigned to 1 A1g→ 1 A2g transition [10,20]. A typical strong band attributed to intra-ligand n→π * transition was observed at 366, 319, 391 nm for the complexes 1, 2 and 3, respectively [10,20]. The UV-visible spectrum of the complex 2 is depicted in Fig.…”

“…These ligands can also act as analytical reagents for determining, fixing and entrapping heavy metal ions [7,8]. The transition metal incorporation into thiosemicarbazones leads to an enhancement in their pharmacological activities [9] and the subsequent synergistic effects involving both metal and the thiosemicarbazone leads to the improvement of their biological activities and decreases the cytotoxicity of both the metal ions and ligands [10]. They bind to the transition metal center in a neutral or anionic form.…”

Synthesis, spectroscopic, biological activities and DFT calculations of nickel(II) mixed-ligand complexes of tridentate Schiff bases

“…The aromatic carbons peaks appeared in the range 162.96-114.75 ppm 8,11,27 . In NiL2NH3 13 C NMR spectrum, the azomethine carbon appeared at 167.38 ppm and the aromatic carbons peaks appeared in the range 156.48-114.77 ppm while the carbon peak for -OCH3 group appeared at δ 55.96 ppm 29,30 . NiL3NH3 13 C NMR spectrum showed the azomethine carbon peak at 167.17 ppm and the aromatic carbons peaks in the range 163.59-111.70 ppm 17 .…”

“…The aromatic protons appeared as multiplets around δ 8.34-6.70 ppm 8,11,27 . The three protons of the methoxy (-OCH3) groups in 'L2' appeared as a sharp singlet signal at δ 3.71 ppm 29,30 . A comparison of the 1 H NMR spectra of the free Schiff base ligands with the Ni(II) mixed-ligand complexes (Figs.…”

Carbothioamide as Highly Efficient Ligand for Copper‐catalyzed Room Temperature Chan–Lam Cross‐Coupling Reaction

“…in the C–N bond formation reaction . We have recently reported the synthesis and characterization of ligand L3 …”