Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy

Philpott, Andrew C.; Hubáček, J.; Sun, Yichun; Hillard, Darlene; Anderson, Todd J.

doi:10.1016/j.atherosclerosis.2012.10.067

Cited by 22 publications

(23 citation statements)

References 31 publications

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“…Included studies were published between 2006 and 2013, and were reported from the USA, 17,20 UK, 18 Germany, 19 Slovenia, 15 Canada 16 and Brazil. 21 All seven studies used either extended-release niacin or no-flush niacin (as inositol hexasuccinate) at a dose range of 1000-2000 mg/day.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…21 All studies were conducted in parallel case-control groups apart from the study by Philpott et al, 16 which was designed as a crossover trial. Four studies were conducted in patients with a history of ACVD or acute coronary syndrome, 15,16,18,19 whilst the other three studies recruited subjects with metabolic syndrome, 20 HIV infection 17 or isolated low HDL-C. 21 Males were the predominant sex in all of the included studies and two studies were exclusively conducted among male subjects. 15,21 Case and control groups were matched regarding age and sex in all of the studies.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…After careful assessment of full-texts, seven articles were found to fulfill the inclusion criteria and were selected for meta-analysis. [15][16][17][18][19][20][21] Reasons for rejecting the other 12 articles were: not measuring FMD, [29][30][31][32][33][34] not having a randomized design, 35 not including an appropriate control group, 36 FMD not being measured in the brachial artery, 37 insufficient data on baseline and/or endpoint FMD values, 22,38 and not being in the English language. 39 A summary of the study selection process is illustrated in Figure 1.…”

Section: Flow Of Included Studiesmentioning

confidence: 99%

“…Four studies used a titrating schedule to reach the predefined dosing of niacin. [16][17][18][19] Duration of treatment with niacin ranged between 12 16,17,19,21 and 52 20 weeks. The largest study had a population size of 106 subjects, 19 whilst the smallest study recruited 22 subjects.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…However, randomized controlled trials investigating the effects of niacin therapy on the brachial artery FMD have yielded inconsistent results. [15][16][17][18][19][20][21][22] The present study aimed to systematically review the literature and perform a meta-analysis of individual findings on the impact of niacin on FMD.…”

Section: Introductionmentioning

confidence: 99%

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Effect of niacin on endothelial function: A systematic review and meta-analysis of randomized controlled trials

Sahebkar

2014

Vasc Med

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Endothelial dysfunction is an independent predictor of incident atherosclerotic cardiovascular disease (ACVD). Niacin possesses high-density lipoprotein (HDL)-elevating, antioxidant and anti-inflammatory properties, all potentially contributing to the amelioration of endothelial function. However, controversies exist among trials reporting the effects of niacin on endothelium-dependent flow-mediated dilation (FMD) as a reliable surrogate of endothelial function. The objective of this study was to assess the effect of niacin on brachial artery FMD using a meta-analysis of available evidence. MEDLINE and Scopus databases were searched for randomized controlled trials investigating the impact of niacin therapy on brachial artery FMD. Meta-analysis of eligible studies was conducted using a random-effects model. Pooled effects were measured by weighted mean difference (WMD) and 95% confidence intervals (CIs). Quality assessment, and subgroup, meta-regression and sensitivity analyses were conducted using standard methods. Among 596 citations, 19 full-text articles were read and seven were found to be eligible for inclusion. Eligible studies involved 441 subjects comprising 228 in the niacin and 213 in the control groups. Niacin therapy significantly improved FMD (WMD: 1.98%; 95% CI: 0.91-3.05%; p = 0.0003) and this effect was robust in the sensitivity analysis. The effect size was greater in the subgroup of studies administering higher doses of niacin (≥ 2000 mg/day) as well as those studies administering niacin for primary prevention of ACVD. Metaregression indicated no association between niacin-induced changes in FMD and changes in plasma HDL-cholesterol, lowdensity lipoprotein-cholesterol or triglycerides. None of the included studies could find any significant effect of niacin on nitroglycerin-mediated dilation. In conclusion, treatment with niacin improves endothelial function.

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Flow Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of niacin on endothelial function: A systematic review and meta-analysis of randomized controlled trials

Sahebkar

2014

Vasc Med

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High Density Lipoproteins

Rj²,

Jw³

2015

Handbook of Experimental Pharmacology

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The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

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Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function

Gomaraschi

Adorni

Banach

et al. 2014

Handbook of Experimental Pharmacology

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Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy

Cited by 22 publications

References 31 publications

Effect of niacin on endothelial function: A systematic review and meta-analysis of randomized controlled trials

Effect of niacin on endothelial function: A systematic review and meta-analysis of randomized controlled trials

High Density Lipoproteins

Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function

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