2002
DOI: 10.1046/j.1463-1326.2002.00205.x
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Niacin treatment of the atherogenic lipid profile and Lp(a) in diabetes

Abstract: These data indicate that in diabetic patients, niacin (i) is effective for treating diabetic dyslipidaemias associated with both the atherogenic lipid profile and Lp(a); (ii) must be used with modern and aggressive oral hypoglycaemic agents or insulin treatment; and (iii) is an important drug to treat diabetes dyslipidaemias because of its broad spectrum of effectiveness.

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Cited by 61 publications
(28 citation statements)
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“…Fibrates and nicotinic acid seem to have more targeted effects on lowering small LDL and increasing the particle size. Nicotinic acid is reported to lower small LDL, specifically the percent distribution of LDL-IIIa, LDL-IIIb, and LDL-IVb, while increasing the percent of LDL-I and LDL-IIa and the LDL peak diameter [154][155][156]. Fenofibrate produces a shift from a predominance of small dense LDL to LDL of intermediate density along with concomitant reductions in plasma triglyceride concentrations [157,158].…”
Section: Drug Effectsmentioning
confidence: 99%
“…Fibrates and nicotinic acid seem to have more targeted effects on lowering small LDL and increasing the particle size. Nicotinic acid is reported to lower small LDL, specifically the percent distribution of LDL-IIIa, LDL-IIIb, and LDL-IVb, while increasing the percent of LDL-I and LDL-IIa and the LDL peak diameter [154][155][156]. Fenofibrate produces a shift from a predominance of small dense LDL to LDL of intermediate density along with concomitant reductions in plasma triglyceride concentrations [157,158].…”
Section: Drug Effectsmentioning
confidence: 99%
“…A beneficial effect on LDL particle distribution in patients with type 2 diabetes could be shown in two studies using final dosages of niacin of 1-4 g per day [78,79].…”
Section: Lipid Lowering Agents Targeting Ldl Particle Distributionmentioning
confidence: 99%
“…Niacin also lowers LDL-C by about 10-15%, TG by about 15-25% and lipoprotein(a) by about 15-25% [86][87][88][89][90] . Niacin has numerous anti-atherothrombotic effects that improve endothelial function, reduce inflammation, increase plaque stability and diminish thrombosis.…”
Section: Niacinmentioning
confidence: 99%