Niazimicin: A thiocarbamate glycoside from
            <i>Moringa oleifera</i>
            Lam. seeds with a novel neuroprotective activity

Abdelsayed, Eman M; Medhat, Dalia; Mandour, Yasmine M.; Hanafi, Rasha S.; Motaal, Amira Abdel

doi:10.1111/jfbc.13992

Cited by 16 publications

(12 citation statements)

References 43 publications

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“…Our results revealed an increased Aβ load in the APP/PS1 mice that was tremendously alleviated by the MO treatment as indicated by the western blot, thioflavin S, and ELISA experiments. This is consistent with our previous study [ 21 ] and a recent study that showed that the component of MO Niazimicin decreases Aβ in albino rate [ 27 ], confirming the ability of MO to reduce Aβ burden.…”

Section: Discussionsupporting

confidence: 93%

“…However, many of the Aβ-targeted therapies have failed [ 17 , 18 , 19 , 20 ]. This failure and the multifactorial complexity of AD trigger therapeutic interest in products with multiple effects such as nutraceuticals such as Moringa oleifera (MO), Tamarix gallica, Ginkgo biloba , Codonopsis pilosula polysaccharide, and Ferulic acid, which have shown potential antioxidative, anti-inflammatory, and neuroprotective virtues among others [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported to have antioxidative, anti-inflammatory, antimicrobial, bactericidal, hypoglycemic, anti-cancer, anti-aging, and neuroprotective potentials [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. In the field of AD, MO was reported to exert anti-aging, antioxidative, anti-cholinesterase, and neuroprotective activities [ 27 , 49 , 56 , 57 , 58 ] and is safe at higher doses in both rats and mice as its LD50 was more than 6400 mg/kg in mice [ 59 , 60 , 61 ]. Moreover, in our previous study [ 21 ], we found that MO can alleviate homocysteine-induced AD-like pathological changes including Aβ production, Tau hyperphosphorylation, and neurodegeneration via decreasing BACE1, GSK-3β, CDK5, CaMKII, increasing PP2A activities, and improving oxidative stress and cognitive deficits.…”

Section: Introductionmentioning

confidence: 99%

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Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

et al. 2022

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Alzheimer’s disease is a global public health problem and the most common form of dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and Tau, and the multifactorial etiology of AD, there is now more and more interest in nutraceutical agents with multiple effects such as Moringa oleifera (MO) that have strong anti-oxidative, anti-inflammatory, anticholinesterase, and neuroprotective virtues. In this study, we treated APP/PS1 mice with a methanolic extract of MO for four months and evaluated its effect on AD-related pathology in these mice using a multitude of behavioral, biochemical, and histochemical tests. Our data revealed that MO improved behavioral deficits such as anxiety-like behavior and hyperactivity and cognitive, learning, and memory impairments. MO treatment abrogated the Aβ burden to wild-type control mice levels via decreasing BACE1 and AEP and upregulating IDE, NEP, and LRP1 protein levels. Moreover, MO improved synaptic plasticity by improving the decreased GluN2B phosphorylation, the synapse-related proteins PSD95 and synapsin1 levels, the quantity and quality of dendritic spines, and neurodegeneration in the treated mice. MO is a nutraceutical agent with promising therapeutic potential that can be used in the management of AD and other neurodegenerative diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

et al. 2022

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“…Quercetin and kaempferol derivatives are the main polyphenols in Moringa oleifera leaves. Many studies have reported that these two kinds of compounds have neuroprotective effects [89,90]. What is worth considering is whether these two kinds of compounds play a major role in the neuroprotective effect of polyphenols in Moringa oleifera leaves.…”

Section: Effect Of Polyphenols In Mlpe Against H 2 O 2 -Induced Oxidative Stress In Pc-12 Neuroblastoma Cellsmentioning

confidence: 99%

Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves

et al. 2022

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Moringa oleifera leaves have been widely used for the treatment of inflammation, diabetes, high blood pressure, and other diseases, due to being rich in polyphenols. The main objective of this work was to largely separate the main polyphenols from Moringa oleifera leaves using the technique of high-speed counter-current chromatography (HSCCC). The phenolic composition in Moringa oleifera leaves was first analyzed qualitatively and quantitatively by UPLC-Q-Exactive Orbitrap/MS and UPLC-QqQ/MS, respectively, indicating that quercetin and kaempferol derivatives, phenolic acid and apigenin are the main polyphenols in Moringa oleifera leaves, with quercetin and kaempferol derivatives predominating. Furthermore, the conditions of HSCCC for large-scale separation of polyphenols from Moringa oleifera leaves were optimized, which included the selection of the solvent system, flow rate and the sample load. Only by one-step HSCCC separation (within 120 min) under the optimized conditions, six quercetin and kaempferol derivatives, a phenolic acid and an apigenin could be individually isolated at a large scale (yield from 10% to 98%), each of which possessed high purity. Finally, the isolated polyphenols and phenolic extract from Moringa oleifera leaves (MLPE) were verified to have strong neuroprotective activities against H2O2-induced oxidative stress in PC-12 cells, suggesting that these compounds would contribute to the main beneficial effects of Moringa oleifera leaves.

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“…The influx of neutrophils, monocytes, and lymphocytes, as inflammatory cells, to the stimulation' site is a fundamental component of inflammation. The activated inflammatory cells at the site of inflammation release chemical mediators such as chemokines, cytokines, eicosanoids and nitric oxide causing elevation in superoxide, hydroxyl radical, hydrogen peroxide and tissue damage [6,9,10]. Thus, the over expression of the proinflammatory genes activates an intracellular signaling cascade generating additional ROS which in turn increase the oxidative stress and inflammatory lesion which drive the progression of liver disorders [6].…”

Section: Introductionmentioning

confidence: 99%

Eicosapentaenoic acid loaded silica nanoemulsion attenuates hepatic inflammation through the enhancement of cell membrane components

Hussein¹,

El‐Bana²,

El-Khayat³

et al. 2022

Biol Proced Online

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Background Liver inflammation is a multistep process that is linked with cell membrane fatty acids composition. The effectiveness of eicosapentaenoic acid (EPA) undergoes an irreversible change during processing due to their unsaturated nature; so the formation of nanocarrier for EPA is crucial for improving EPA’s bioavailability and pharmacological properties. Objective In this study we aimed to evaluate the efficiency of EPA alone or loaded silica nanoemulsion on the management of hepatic inflammation induced by diethyl nitrosamine (DEN) through the enhancement of the cell membrane structure and functions. Methods The new formula of EPA was prepared to modify the properties of EPA. Forty-eight male Wistar albino rats were classified into: control, EPA, EPA loaded silica nanoemulsion (EPA–NE), DEN induced hepatic inflammation; DEN induced hepatic inflammation treated with EPA or EPA –NE groups. Plasma tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), liver hydroxyproline (Hyp) content, and liver oxidant and anti-oxidants were estimated. Urinary 8- hydroxyguanozine (8- OHdG) and erythrocyte membrane fatty acids fractions were estimated by High-performance liquid chromatography (HPLC). Also, histopathology studies were done to verify our hypothesis. Results It was appeared that administration of EPA, in particular EPA loaded silica nanoemulsion, ameliorated the inflammatory response, increased the activity of the anti-oxidants, reduced levels of oxidants, and improved cell membrane structure compared to hepatic inflammation induced by DEN group. Histopathological examination confirmed these results. Conclusion EPA and notably EPA loaded silica nanoemulsion strongly recommended as a promising supplement in the management of hepatic inflammation.

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Niazimicin: A thiocarbamate glycoside from Moringa oleifera Lam. seeds with a novel neuroprotective activity

Cited by 16 publications

References 43 publications

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves

Eicosapentaenoic acid loaded silica nanoemulsion attenuates hepatic inflammation through the enhancement of cell membrane components

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