Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety

Laas, Kariina; Kiive, Evelyn; Mäestu, Jarek; Vaht, Mariliis; Veidebaum, Toomas; Harro, Jaanus

doi:10.1016/j.jad.2017.03.045

Cited by 41 publications

(28 citation statements)

References 45 publications

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“…Our results indicate the possibility that the GG allele variant previously associated with lower risk for depression (Gao et al., ) also may play a role in positive emotional development, fitting the transactional model of child positive affects suggested by Davis and Suveg (). However, in a recent study, the TT genotype was associated with a more favorable outcome by young adulthood, especially in males (Laas et al., ). Further studies are needed, as the role of genes in child psychological development has proven to be quite complex.…”

Section: Discussionmentioning

confidence: 91%

Maternal and infant characteristics connected to shared pleasure in dyadic interaction

Puura

Leppänen

Salmelin

et al. 2019

Infant Mental Health Journal

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The aim of the study was to analyze which maternal factors (depressive symptoms, effect of life events, maternal sensitivity and structuring) and infant characteristics (temperament, social withdrawal symptoms, interactive behavior, genotype, gender) contribute to shared pleasure (SP) in parent–infant interaction. Participants were 113 mother–infant dyads. The mothers filled in the Edinburgh Postnatal Depression Scale, the Infant Behavior Questionnaire, and the Life Events Questionnaire. The dyads were videotaped in a free‐play situation, and the videos were analyzed using the Alarm Distress Baby Scale and the Emotional Availability Scales. The infants were genotyped for four genes involved in emotion regulation. The occurrence and duration of SP (SP‐MD) in mother–infant interactions were analyzed from the videotapes. Higher maternal sensitivity and depressive symptoms, better infant responsiveness, and the infant having the GG variant of the gene tryptophan hydroxylase isoform 2 (TPH2) ‐307 were associated with the occurrence of SP. Lower level depressive symptoms, better maternal structuring, and greater infant involvement were associated with the longer duration of SP. Those dyads where the mother and infant were best able to read each other's positive cues and to respond to them were more likely to experience mutual positive affect, as seen in SP.

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Section: Discussionmentioning

confidence: 91%

Maternal and infant characteristics connected to shared pleasure in dyadic interaction

Puura

Leppänen

Salmelin

et al. 2019

Infant Mental Health Journal

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“…to action with less forethought than risk-free, but high Maladaptive impulsivity has high harm risk while Adaptive impulsivity supports success by agility. Previously, AMIS has been applied in a series of studies on risk-taking behaviour and impulsivity-related candidate genes studies, and found to have good predictive validity (e.g., Eensoo et al, 2004;Paaver et al, 2006;Laas et al, 2015a;Laas et al 2015b;Laas et al, 2017;Luht et al, 2019) At age 25, the Mini-International Neuropsychiatric Interview (MINI.5.0.0), (Sheehan et al, 1998) Estonian version (Shlik et al, 1999) Likert scale questions about misprize within the family and about emotional and physical abuse (Paaver et al, 2008;Kiive et al, 2010).…”

Section: Samplementioning

confidence: 99%

Low cholesterol levels in children predict impulsivity in young adulthood

Tomson-Johanson

Kaart

Kiivet

et al. 2019

Acta Neuropsychiatr.

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AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

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“…In this study, the opposite association between higher ELS and increased brain volumes observed in the TPH2 rs4570625TT homozygotes contrasts with previous reports on a genetic susceptibility for pronounced ELS-associated brain structural deficits. While some studies that combined the low-frequency TPH2 rs4570625 T-carrier groups initially revealed increased psychopathological risk (Gao et al 2012), anxiety-associated traits (Gutknecht et al 2007) and detrimental effects of ELS (Mandelli et al 2012;Forssman et al 2014), accumulating evidence indicates that TT homozygotes differ from both other variants in terms of lower anxiety-related behavior and psychopathological risk (Reuter et al 2007;Lehto et al 2015;Laas et al, 2017;Ottenhof et al 2018). While reduced gray matter volumes in limbicprefrontal regions have been consistently reported in psychiatric disorders characterized by exaggerated anxiety and deficient emotion regulation (van Tol et al 2010;Bora et al 2012;Ahmed-Leitao et al 2016), associations between emotional functioning and limbic-prefrontal volumes in healthy subjects remain less clear, such that elevated anxiety has been associated with both, volumetric increases as well as decreases in this circuitry (e.g.…”

Section: Discussionmentioning

confidence: 99%

Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior – a TPH2 imaging genetics approach

Liu¹,

Lei²,

Li³

et al. 2019

Preprint

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Serotonin regulates developmental and experience-dependent neuroplasticity in limbicprefrontal systems engaged in emotional reactivity and regulation. Tryptophan hydroxylase 2 (TPH2) regulates central serotonergic biosynthesis rates and transgenic animal models suggest that TPH2-associated changes in serotonergic signaling mediate the impact of early life stress (ELS) shaping a phenotype characterized by anxious avoidance. The present study employed an imaging genomics approach that capitalized on individual differences in a TPH2 polymorphism (703G/T; rs4570625) to determine whether differences in serotonergic signaling modulate the effects of ELS on brain structure and function and punishment sensitivity in humans (n = 252). Higher ELS exposure was associated with increased gray matter volumes in a circuitry spanning thalamic-limbic-prefrontal regions and decreased intrinsic communication in limbic-prefrontal circuits selectively in TT carriers. On the phenotype level, the genotype moderated the association between higher ELS exposure and higher punishment sensitivity. In TT carriers, the association between higher ELS exposure and punishment sensitivity was critically mediated by increased thalamic-limbic-prefrontal volumes. The present findings suggest that ELS shapes the neural organization of the thalamic-limbic-prefrontal circuits in interaction with individual variations in TPH2 to promote a phenotype characterized by facilitated threat avoidance, thus promoting early adaptation to an adverse environment.

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Nice guys: Homozygocity for the TPH2 -703G/T (rs4570625) minor allele promotes low aggressiveness and low anxiety

Abstract: Subjects with the TPH2 rs4570625 TT genotype, especially males, exhibit less aggression and a favourable impulsivity profile, and develop anxiety disorders by young adulthood less often.

Cited by 41 publications

References 45 publications

Maternal and infant characteristics connected to shared pleasure in dyadic interaction

Maternal and infant characteristics connected to shared pleasure in dyadic interaction

Low cholesterol levels in children predict impulsivity in young adulthood

Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior – a TPH2 imaging genetics approach

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