NICE verdict on Temozolomide: where next?

Brada, Michael

doi:10.1038/sj.bjc.6600134

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…The synthetic name for paclitaxel is 5β, 20-Epoxy-l, 2α, 4, 7β, 10β,13α-hexahydroxytax -l-en-nine-one four,10-diacetate 2-benzoate thirteen-ester with (2R,3S)-Nbenzoyl-three-phenylisoserine. Paclitaxel is a white to grayish translucent powder with the exact segments C47H51NO14 and a sub-atomic load of 853.9 g/mol [9,10]. Paclitaxel is tremendously lipophilic, and lique ies at cycle 216-217 • C and is utilized in cure of assorted propelled carcinomas along with ovar-ian most malignant growths, lung disease, bosom most tumors, intense leukemias, head and neck malignancies and Kaposi's sarcoma [11][12][13].…”

Section: Related Workmentioning

confidence: 99%

The treatment of cancer by influenced of alpha and beta momorcharin

P¹,

Cr²,

Vinaya³

et al. 2018

irjpas

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A huge number of plant had been utilized quite for the cure of malignant growths all through the segment. The protein, β ,α, momorcharin has been removed from the plant Momordica charantia (MC), and it has threatening to most dangerous developments and against HIV properties like the foul aquatic and methanol dissolvable concentrate of the plant. This assessment investigated the counter threatening development impacts and the telephone frameworks of advancement of α, β momocharin (200 800 μM) on 1321N1, Gos-three, U87-MG, Sk Mel, Corl-23 and Weri Rb-1 most illnesses convenient strains when appeared differently in relation to normal solid L6 muscle cell line evaluating flexible achievability the usage of MTT measure group, Caspase-three and 9 games, cytochrome c release and intracellular free calcium obsessions [Ca(2+)]i. The results show that α, β momorcharin can bring huge part subordinate (P < zero.05; Student's t examine) reduces in the appropriateness (increases in cell loss of life) of 1321N1, Gos-3, U87-MG, Sk Mel, Corl-23 and Weri Rb-1 harmful development cell follows when appeared differently in relation to solid L6 muscle cell line and untreated glioma cells. α, β momorcharin (800 μM) additionally evoked extraordinary evaluated (P < zero.05) will increase in caspase-three and nine activities and cytochrome c dispatch. Along these lines, α, β momorcharin evoked gigantic (P < 0.05) time-subordinate tallness in [Ca(2+)]i in all of the 5 glioma cell strains conversely with untreated cells. Together, the results have attempted that α, β momorcharin can apply its enemy of malignancy impact on elite disease cell lines by means of intracellular procedures identified with an affront to the mitochondria bringing about cell calcium over stacking, apoptosis, cytochrome discharge and at long last, cell death toll.

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Section: Related Workmentioning

confidence: 99%

The treatment of cancer by influenced of alpha and beta momorcharin

P¹,

Cr²,

Vinaya³

et al. 2018

irjpas

View full text Add to dashboard Cite

show abstract

“…The chemical name for paclitaxel is 5β, 20-Epoxy-l, 2α, 4, 7β, 10β,13αhexahydroxytax-l l-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine. Paclitaxel is a white to off-white crystalline powder with the empirical formula C 47 H 51 NO 14 and a molecular weight of 853.9 g/mol [9,10]. Paclitaxel is highly lipophilic, and melts at around 216-217°C and is used in treatment of various advanced carcinomas such as ovarian cancer, lung cancer, breast cancer, acute leukemias, head and neck cancers and Kaposi's sarcoma [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effects of alpha, beta momorcharin fruit extract with the combination of paclitaxel in the treatment of glioma cancer in-vivo.

Manoharan

2019

IJCRPP

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The vegetable Momordica charantia L., (family: Cucurbitaceae) is a scientific name of the plant and its fruit. It is also known by other names, for instance in the USA it is known as Bitter gourd or balsam pear while its referred to as the African cucumber in many African countries. M.charantiais believed to posse’s anti-carcinogenic properties and it can modulate its effect via xenobiotic metabolism and oxidative stress. This study was specifically designed to investigate the cellular mechanisms whereby α, β momorcharin an extract of M. charantiacan induce cell death with the combination of paclitaxel. Different concentration (200µM - 1000µM)of the α, β momorcharin fruit extract were treated (24 hrs incubation) separately with three different cancer cell lines 1321N1, Gos-3, U87-MG and normal L6 muscle cell line. The results also show that paclitaxel(250 µg) with (1000 µM) of the α, β momorcharinextract of M. Charantia,and result in significant decreases in cell viability for each cell line, these effects were additive compared to the individual effect of paclitaxel.

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“…Temozolomide is an analogue of DTIC that spontaneously degrades at physiologic pH to methyl triazemoimidazole carboximide, the active metabolite of DTIC. Temozolomide has the advantages of being absorbed orally and possessing significant central nervous system penetration [6][7][8][9], and this drug is active in the treatment of anaplastic astrocytoma [10]. In melanoma, temozolomide administered daily for 5 days every 4 weeks at the dose of 200 mg/m 2 was shown in a phase III trial to have activity comparable to DTIC [6].…”

Section: Introductionmentioning

confidence: 99%

Complete Response of Multiple Melanoma Brain Metastases after Treatment with Temozolomide

Dvořák¹,

Melichar²,

Žižka³

et al. 2004

Oncol Res Treat

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Background: Inoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare. Case report: A patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance. Conclusions: The present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.

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NICE verdict on Temozolomide: where next?

Abstract: British Journal of Cancer (2002) 86 , 499–500. DOI: 10.1038/sj/bjc/6600134 www.bjcancer.com © 2002 Cancer Research UK

Cited by 7 publications

References 12 publications

The treatment of cancer by influenced of alpha and beta momorcharin

The treatment of cancer by influenced of alpha and beta momorcharin

Effects of alpha, beta momorcharin fruit extract with the combination of paclitaxel in the treatment of glioma cancer in-vivo.

Complete Response of Multiple Melanoma Brain Metastases after Treatment with Temozolomide

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