Nicergoline in the treatment of neuropathic bladder dysfunction: a preliminary report

Gállego, José Antonio Gutiérrez; Forner, V; Jiménez, Fiacro; Martínez, Enrique Perea

doi:10.1038/sc.1984.37

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various studies have reported other minor effects with nicergoline; these include hot flushes [37, 42], dizziness [41], inhibition of ejaculation [43], and interstitial nephritis [44]. While hot flushes can be due to the effects of nicergoline on blood vessels, inhibition of ejaculation is a known side-effect of alpha adrenergic blockers.…”

Section: Concerns Regarding Safety Of Nicergolinementioning

confidence: 99%

Safety of Nicergoline as an Agent for Management of Cognitive Function Disorders

Saletu

Garg

Shoeb

2014

BioMed Research International

View full text Add to dashboard Cite

Nicergoline is a semisynthetic ergot derivative and has a selective alpha-1A adrenergic receptor blocking property and also other additional mechanisms of actions, both in the brain and in the periphery. It is in clinical use for over three decades in over fifty countries for conditions such as cerebral infarction, acute and chronic peripheral circulation disorders, vascular dementia, and Alzheimer's disease and has been found to be beneficial in a variety of other conditions. However, concerns about its safety have been raised, especially after the European medicines agency's (EMEA's) restriction in the use of all ergot derivatives including nicergoline. But, most of the available literature and data suggest that the adverse events with nicergoline are mild and transient. Further, none of the available treatment options for cognitive disorders afford definitive resolution of symptoms. In this backdrop, we discuss the pharmacology of nicergoline with special emphasis on the safety of this compound, especially when used in patients suffering from cognitive function disorders.

show abstract

Section: Concerns Regarding Safety Of Nicergolinementioning

confidence: 99%

Safety of Nicergoline as an Agent for Management of Cognitive Function Disorders

Saletu

Garg

Shoeb

2014

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Various studies have reported other minor effects with nicergoline including hot flushes, dizziness, ejaculation failure and interstitial nephritis 42 43…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline

Fioravanti¹,

Nakashima²,

Xu³

et al. 2014

BMJ Open

View full text Add to dashboard Cite

ObjectiveTo evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.DesignSystematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.Data sourcesMEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline. Studies published until August 2013 were included.Review method29 studies were included for data extraction. The studies included in this review were majorly from European countries and mostly in cerebrovascular disease (n=15) and dementia (n=8).ResultsThe treatment withdrawals were comparatively lower in the nicergoline group as compared with the placebo group (RR=0.92; 95% CI 0.7 to 1.21) and other active comparators (RR=0.45; 95% CI 0.10 to 1.95), but the difference was non-significant. Incidence of any adverse events (AEs) was slightly higher (RR=1.05; 95% CI 0.93 to 1.2) while incidence of serious AEs was lower (RR=0.85; 95% CI 0.50 to 1.45) in the nicergoline compared with placebo group. Frequency of anxiety was significantly lower in nicergoline as compared with placebo (p=0.01). Other AEs including diarrhoea, gastric upset, dizziness and drowsiness were less frequent in the nicergoline group when compared with placebo/active drugs, but the difference was non-significant. Frequency of hypotension and hot flushes was slightly higher in the nicergoline group but the difference was non-significant. None of the studies reported any incidence of fibrosis or ergotism with nicergoline treatment.ConclusionsNicergoline is an ergot derivative, but its safety profile is better than other ergot derivatives like ergotamine and ergotoxine. This systematic review and meta-analysis suggests that nicergoline has a good safety profile. None of the studies included in this systematic review reported any incidence of fibrosis or ergotism with nicergoline.

show abstract

The Present Role of Alpha-Adrenergic Blockers in the Treatment of Benign Prostatic Hypertrophy

1986

View full text Add to dashboard Cite

Nicergoline in the treatment of neuropathic bladder dysfunction: a preliminary report

Cited by 3 publications

References 21 publications

Safety of Nicergoline as an Agent for Management of Cognitive Function Disorders

Safety of Nicergoline as an Agent for Management of Cognitive Function Disorders

A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline

The Present Role of Alpha-Adrenergic Blockers in the Treatment of Benign Prostatic Hypertrophy

Contact Info

Product

Resources

About