Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species

Barbour, Alan G.; Bunikis, Jonas; Travinsky, Bridgit; Hoen, Anne G.; Diuk‐Wasser, Maria A.; Fish, Durland; Tsao, Jean I.

doi:10.4269/ajtmh.2009.09-0208

Cited by 281 publications

(312 citation statements)

References 63 publications

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“…The lack of age dependence for B. miyamotoi infection, along with the absence of significant difference in infection rates of the bladder across months, suggests that, unlike B. garinii and B. afzelii, it does not result in persistent infections of the urinary bladder. It has also been shown that skin samples from mice had lower infection rates than blood (Barbour et al 2009), and evaluation of spleen samples suggested that this organ is also not a focus of persistent infection (data not shown). However, we cannot yet exclude the possibility that B. miyamotoi persists in other organs.…”

Section: Discussionmentioning

confidence: 99%

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Borrelia miyamotoiInfections among Wild Rodents Show Age and Month Independence and Correlation withIxodes persulcatusLarval Attachment in Hokkaido, Japan

Taylor

Takano

Konnai

et al. 2013

Vector-Borne and Zoonotic Diseases

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To clarify how Borrelia miyamotoi is maintained in the environment in Hokkaido, we examined Ixodes persulcatus for its prevalence among wild rodents and its tick vector by detecting a portion of the borrelial flaB gene in rodent urinary bladder and blood samples, and from whole ticks. We compared B. miyamotoi infection rates to Borrelia garinii and Borrelia afzelii, which are human Lyme disease pathogens also carried by wild rodents, and which are transmitted by the same vector tick. Whereas B. garinii and B. afzelii showed age dependence of infection rates among wild rodents (18.4% and 9.9% among adults and 6.0% and 3.4% among sub-adults, respectively) when looking at urinary bladder samples, B. miyamotoi infection rates were not age dependent for either blood (4.2% among adults, and 7.9% among sub-adults) or urinary bladder samples (1.0% among adults, and 1.7% among sub-adults). Moreover, while B. garinii and B. afzelii infection rates showed increases across months ( June, July [p < 0.05] and August [p < 0.01] had higher rates than in May for adult rodents with B. garinii, and July and August had higher rates than in May [p < 0.01] for adult rodents with B. afzelii), B. miyamotoi infection rates did not show significant month dependence. These differences in month and age dependence led us to suspect that B. miyamotoi may not develop persistent infections in wild rodents, as B. garinii and B. afzelii are thought to. Furthermore, we examined the extent of rodent exposure to I. persulcatus nymphs and larvae throughout most of the tick's active season (May through September), and determined that B. miyamotoi infection rates in sub-adult rodents were correlated with larval burden ( p < 0.01), suggesting that larvae may be very important in transmission of B. miyamotoi to wild rodents.

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Section: Discussionmentioning

confidence: 99%

“…In Japan, B. miyamotoi is carried by the vector tick Ixodes persulcatus, as it is in other parts of Asia (Fukunaga et al 1995, Fomenko 2010. I. scapularis, I. pacificus, and I. ricinus are the vectors in their respective ranges in other parts of the world (Fraenkel et al 2002, Mun et al 2006, Barbour et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Borrelia miyamotoiInfections among Wild Rodents Show Age and Month Independence and Correlation withIxodes persulcatusLarval Attachment in Hokkaido, Japan

Taylor

Takano

Konnai

et al. 2013

Vector-Borne and Zoonotic Diseases

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“…As a large proportion of the population rely on herding, the impact of TBPs on domestic livestock is also of interest given that domestic animals can contract TBPs [1,13,24,37] and can serve as a vector for the transfer of infected ticks to humans. Recent studies of domestic animals in Mongolia identified antibody responses to B. burgdorferi , SFGR, and Anaplasma spp.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, if ear biopsy samples were positive by PCR, animals were determined positive for Borrelia spp. [24–26]. …”

Section: Methodsmentioning

confidence: 99%

A cross-sectional study of small mammals for tick-borne pathogen infection in northern Mongolia

Pulscher

2018

Infection Ecology & Epidemiology

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Background: Tick-borne pathogens (TBPs) are frequently studied in developed nations but are often neglected in emerging countries. In Mongolia, TBP research is especially sparse, with few research reports focusing upon human and domestic animal disease and tick ecology. However, little information exists on TBPs in small mammals. Methods: In this 2016 cross-sectional pilot study, we sought to uniquely study wildlife for TBPs. We live-trapped small mammals, and tested their whole blood, serum and ear biopsy samples for molecular or serological evidence of Borrelia spp., Rickettsia spp., and Anaplasma spp./Ehrlichia spp. Results: Of 64 small mammals collected, 56.0%, 39.0% and 0.0% of animals were positive by molecular assays for Borrelia spp., Rickettsia spp., and Anaplasma spp./Erhlicia spp., respectively. 41.9% were seropositive for A. phagocytophilum and 24.2% of animals were seropositive for Rickettsia rickettsii. Conclusion: This pilot data demonstrates evidence of a number of TBPs among small mammal populations in northern Mongolia and suggests the need to further investigate what role these mammals play in human and domestic animal disease.

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“…Vadon élő rágcsálókban, amelyek újra és újra fertő-ződnek kullancslárvákkal, B. miyamotoi bacteraemia volt megfigyelhető, így fontos szerepük lehet ennek a kór-okozónak a fenntartásában is [11,12].…”

Section: A Borrelia Miyamotoi Előfordulása Vektorokbanunclassified

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Szekeres

Lakos²,

Földvári

2017

Orvosi Hetilap

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A Borrelia miyamotoi-t 1995-ben fedezték fel. Ez egy, emberben visszatérő lázat (relapsing fever, febris recurrens) okozó baktérium, amelyet az Ixodes ricinus fajcsoportba tartozó kullancsok terjesztenek. Ez a kórokozó genetikailag, járványtanilag és az általa okozott kórkép tekintetében is különbözik a szintén kullancsok által terjesztett Borrelia burgdorferi sensu lato (Lyme spirochaeta) baktériumoktól. Eddig világszerte több mint 50 heveny lázas megbetegedésben szenvedő páciensből mutatták már ki, ezenfelül három tumoros betegben meningoencephalitist okozott ez a kórokozó. A különböző élőhelyeken található kullancsok és gazdáik fertőzöttségének mértéke, eloszlása és a fertőzés mechanizmusa nem tisztázott még. A B. miyamotoi elsősorban lázat okoz, ami miatt más, kullancsok által terjesztett fertőzésekkel is összetéveszthető. Az utóbbi évek intenzív vizsgálatai alapján nemcsak egyre több földrajzi régióból mutatják ki ezt a baktériumot kullancsokból, de folyamatosan növekszik a publikált humán esetszám is, ezért növek-vő jelentőségű (emerging) kórokozóként tartják számon. Irodalmi áttekintésünkben összegezzük az eddigi ismereteinket a Borrelia miyamotoi-val kapcsolatban. Orv Hetil. 2017; 158(29): 1124-1130. Kulcsszavak: Borrelia miyamotoi, kullancs, visszatérő láz, kullancs által terjesztett fertőzések Borrelia miyamotoi: a recently identified human pathogenic tick-borne relapsing fever spirocheteBorrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited. The most common symptom is fever; thus it can be easily confused with other tick-borne diseases. Due to the intensive research in recent years, Borrelia miyamotoi infection in ticks and hosts has been reported from different regions and also the number of patients is increasing, thus this bacterium is considered as an emerging pathogen. In this literature review we would like to summarize the available knowledge about this spirochete.

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Niche Partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the Same Tick Vector and Mammalian Reservoir Species

Cited by 281 publications

References 63 publications

Borrelia miyamotoiInfections among Wild Rodents Show Age and Month Independence and Correlation withIxodes persulcatusLarval Attachment in Hokkaido, Japan

Borrelia miyamotoiInfections among Wild Rodents Show Age and Month Independence and Correlation withIxodes persulcatusLarval Attachment in Hokkaido, Japan

A cross-sectional study of small mammals for tick-borne pathogen infection in northern Mongolia

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

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