Nickel-Catalyzed Deaminative Alkyl–Alkyl Cross-Coupling of Katritzky Salts with Cyclopropanols: Merging C–N and C–C Bond Activation

Abstract

Herein, we report a general and practical nickelcatalyzed deaminative alkylation of Katritzky salts with cyclopropyl alcohols via merging C−N and C−C bond activation. This protocol enables the formation of an alkyl−alkyl bond along with the generation of a versatile ketone functional group in a single operation, thus providing a convenient approach for accessing βalkyl ketones. This reaction is distinguished by its high functional group tolerance, broad substrate scope, and efficient late-stage derivatization of complex bioactive molecules.