Nickel-catalyzed multicomponent heterocyclization of 2,4-pentanedione to sulfanylmethyl-1H-pyrazoles

Synthesis of newN,N′-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of theirin vitroanticancer activity

“…Synthesis of 4-((sulfanyl)methyl)-3,5-dimethyl-1H-pyrazoles 4a-d. Synthesis of 4-((sulfanyl)methyl)-3,5-dimethyl-1H-pyrazoles 4a-d was carried out according to the procedure described previously. 24 The spectral characteristics of the obtained pyrazole ligands 4a-d are consistent with published data. 24 The lipophilicity of benzyl-and cyclohexylsulfanylpyrazoles 4b,c was evaluated by reversed phase HPLC on a liquid chromatography Schimadzu LC-20 Prominence column -LiChrospher 100 rp-18, 250 mm  4.0 mm, 5 mm, the eluent CH 3 CN-H 2 O, ow rate 2 mL min À1 , l 260 nm.…”

“…24 The spectral characteristics of the obtained pyrazole ligands 4a-d are consistent with published data. 24 The lipophilicity of benzyl-and cyclohexylsulfanylpyrazoles 4b,c was evaluated by reversed phase HPLC on a liquid chromatography Schimadzu LC-20 Prominence column -LiChrospher 100 rp-18, 250 mm  4.0 mm, 5 mm, the eluent CH 3 CN-H 2 O, ow rate 2 mL min À1 , l 260 nm. 26 3 Synthesis of N,N 0 -platinum complexes.…”

“…Recently, we have proposed a four-component one-pot synthesis of sulfanyl pyrazoles, 24 which are promising ligands for the synthesis of potential metal-containing cytostatics.…”

“…The structure of compounds 4a-d was reliably conrmed by spectral methods. 24 For compound 4d, a single crystal was grown and studied by X-ray diffraction (Fig. 2).…”

Reaction of 3-(Alkylsulfanylmethyl)pentane-2,4-diones and 4-(Alkylsulfanyl)-3-(alkylsulfanylmethyl)butan-2-ones with Phenylhydrazine in the Presence of Zinc Chloride

“…Functionally substituted pyrazole ring is a structural unit of natural compounds [1] and modern medicines with a lower number of side effects [2,3]; pyrazole derivatives exhibit a broad spectrum of biological activity [2][3][4][5][6][7][8][9] and are used to obtain mixed-ligand coordination compounds necessary for homogeneous catalysis [10]. Some 4(2)-[alkyl(aryl)sulfanylmethyl]substituted 1H-pyrazoles were found to inhibit N-myris toyl transferase [11] and α-amylase [12] and act as progesterone receptor antagonists [13], antioxidants [14], fungicides [15], and efficient and selective extractants and ligands in the synthesis of sulfur-containing platinum(II) and palladium(II) complexes [16][17][18]. 4-[Alkylsulfanyl(sulfonyl)methyl]-1H-pyrazoles can be synthesized from the corresponding halogen-substituted pyrazoles [13,18].…”