Nickel-Cobalt Salen Organometallic Complexes Encapsulated in Mesoporous NaA Nanozeolite for Electrocatalytic Quantification of Ascorbic Acid and Paracetamol

Abstract

Goal of current study was fabrication of novel voltammetric nanosensor for the synchronize quantification of ascorbic acid (AA) and paracetamol (PAR) by nickel-cobalt salen complexes encapsulated in the supercages of NaA nanozeolite modified carbon paste electrode (NiCoSalenA/CPE). For this purpose, NiCoSalenA nanocomposite was firstly prepared and characterized by various methods. Also, cyclic voltammetry (CV), choronoamperometry (CHA) and differential pulse voltammetry (DPV) were utilized to evaluate performance of the modified electrodes. The effects of pH and modifier amount were considered on the electrochemical oxidation of AA and PAR on the surface of NiCoSalenA/CPE. Results from this method indicated that pH of 3.0 in phosphate buffer solution (0.1 M) and 15 wt% of NiCoSalenA nanocomposite in the modified CPE results in the maximum current density. The oxidation signals of AA and PAR was amplified affectively at NiCoSalenA/CPE versus unmodified CPE. The limit of detection (LOD) and linear dynamic range (LDR) for the simultaneous measurement of them were founds to be 0.82 and 2.73–80.70 for AA and 0.51 µM, 1.71–32.50 and 32.50–137.60 µM for PAR, respectively. The catalytic rate constants ( k cat ) were attained to be 3.73 × 10 7 and 1.27 × 10 7 cm 3 mol −1 s −1 for AA and PAR via CHA method, respectively. Also, the amounts of diffusion coefficient ( D ) were found to be 1.12 × 10 −7 and 1.92 × 10 −7 cm 2 s −1 for AA and PAR, respectively. The average value of electron transfer rate constant between NiCoSalenA/CPE and PAR was obtained to be 0.016 s −1 . The NiCoSalen-A/CPE displayed worthy stability, repeatability and extraordinary recovery for simultaneous measurements of AA and PAR. Application of offered sensor was confirmed by quantifying concentrations of AA and PAR in human serum solution as a real sample.

Modification of Glassy Carbon Electrodes with Complexes of Manganese(II) with Some Phenanthroline Derivatives Immobilized in Nafion Layer

“…The choice of ascorbic acid was driven by the very well-described mechanism of its catalytic oxidation in the literature [39,40], resulting from the very high interest in this compound. Ascorbic acid has been studied for a long time [39,40] and is still an object of catalytic research [41,42]. In the presence of various catalysts, the catalytic oxidation processes are stable, giving hope for a measurable electrocatalytic effect.…”

Screen‐Printed Carbon Electrodes Modified with Poly(amino acids) for the Simultaneous Detection of Vitamin C and Paracetamol

“…[6] Numerous reports address the detection of VC or PA in conjunction with other drugs, [6][7] but there is limited literature on simultaneous VC and PA detection using poly(amino acid)-modified electrodes. [3a] Fo example Masihpour et al [8] introduced a voltammetric nanosensor, the NaA nanozeolite modified carbon paste electrode (NiCoSalenA/CPE), demonstrating notable catalytic rate constants (k) of 3.73×10 7 and 1.27×10 7 cm 3 mol À 1 s À 1 for VC and PA, respectively, accompanied by low limits of detection (0.82 μM for VC and 0.51 μM for PA) and wide linear dynamic ranges (2.73-80.70 μM for VC and 1.71-32.50 μM, 32.50-137.60 μM for PA). Screen printing technology, a modern technique, is employed to manufacture miniaturized and sensitive portable electrochemical sensors.…”