Nickel excretion in urine after oral administration*

Menné, Torkil; Mikkelsen, Heidi; Solgaard, Per Bent

doi:10.1111/j.1600-0536.1978.tb03743.x

Cited by 17 publications

(4 citation statements)

References 10 publications

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“…(276) Information on nickel absorption in the alimentary tract is available from several controlled studies of adult human volunteers ingesting nickel in food or drinking water, with or without fasting. Menne et al (1978) studied nickel excretion in urine for 3 d after oral administration of 5.6 mg as the sulphate to six female and seven male volunteers, aged 29-64 y, with psoriasis or leg ulcers. Analysis here gave a mean absorbed fraction of 0.02 with a range from 0.003 to 0.05.…”

Section: Controlled Human Ingestion Studiesmentioning

confidence: 99%

“…The toxicokinetics of these two forms have been investigated in human subjects, dogs, rabbits, mice, rats, hamsters, guinea pigs, farm animals, and a variety of non-human primates. Several biokinetic models for inorganic arsenic have been proposed (Menzel et al., 1994; Mann et al., 1996; Yu, 1999; El-Masri and Kenyon, 2008; Ling and Liao, 2009; Adeyemi et al., 2010). (353) Absorbed or injected inorganic As(III) and As(V) initially have noticeably different systemic kinetics (Vahter and Norin, 1980; Lindgren et al., 1982).…”

Section: Arsenic (Z = 33)mentioning

confidence: 99%

See 1 more Smart Citation

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

Paquet¹,

Leggett²,

Blanchardon³

et al. 2022

Ann ICRP

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Section: Controlled Human Ingestion Studiesmentioning

confidence: 99%

Section: Arsenic (Z = 33)mentioning

confidence: 99%

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

Paquet¹,

Leggett²,

Blanchardon³

et al. 2022

Ann ICRP

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“…In food intake, 5Á/10% of total nickel is absorbed in the gastrointestinal tract and the rest is excreted in the faeces. Studies with radioactive-labelled nickel have indicated that orally ingested nickel is rapidly eliminated in urine by the kidneys, and little accumulation and symptoms are found in the organs within 8Á/24 h of exposure to high dose nickel (Menne et al, 1978;Pandey et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Urinary nickel: measurement of exposure by inductively coupled plasma argon emission spectrometry

et al. 2004

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Nickel is a rare earth metal and is widely used in modern industry. Its overexposure in human beings can provoke significant effects including lung, cardiovascular and kidney diseases. As an index of occupational exposure, urine is widely used for the monitoring of nickel concentration because it is a minimally invasive method. Recent studies have used atomic absorption spectrometry to measure nickel concentration. In this study, we introduced novel inductively coupled plasma argon emission spectrometry (ICPAES) which enables us to measure multiple elements simultaneously with smaller volume and with lower detection limits compared to conventional atomic absorption emission spectrometry, and we established the new measuring method by determining the appropriate wavelengths for nickel concentration. Furthermore, using the established new measuring method, we investigated the correlation between a single oral administration of nickel and urine elimination in rats. As a result, different concentrations of nickel standard solutions were measured by ICPAES, and among five specific wavelengths of nickel, 221.647 and 231.604 nm were chosen because they had the highest inclines of both signal to background ratio and emission intensity in simple linear regression analysis. Next, by using healthy human urine samples that had not been exposed to nickel, 231.604 nm was determined to be the most appropriate wavelength because it did not present abnormal intensity due to obstacle wavelength. Male Wistar rats received an oral administration of nickel ranging from 0.025 to 250 mg/kg, which is equivalent to 0.0015 - 15% of LD50, and during the following 24 h, urine samples were collected and the nickel concentration was measured by ICPAES. With a single oral administration of nickel, there was an increase in urine nickel concentration in a dose-dependent manner and the appropriate equation was developed. Acute renal failure was not observed in this dosage of oral nickel administration by analysing NAG, beta2-microglobulin, urine albumin and urine protein. It was concluded that the obtained nickel reference values using ICPAES would be useful for the early diagnosis of nickel intoxication and in the assessment of the exposure to nickel.

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“…Menné and Thorboe showed that the urine nickel concentration was elevated in 4 women with vesicular hand eczema prior to eruption of vesicles when compared to periods without vesicles (52). Later, Menné et al studied nickel concentrations in urine from 13 patients with psoriasis or leg ulcers (53). Each subject ingested 5.6 mg of nickel, resulting in elevated urine nickel concentrations in the following days.…”

mentioning

confidence: 99%

Contact allergy and human biomonitoring - an overview with a focus on metals

2011

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Humans are widely exposed to chemicals. Today, there is an increased acknowledgement of the importance of measuring human and environmental exposures to man-made or refined chemicals. Different approaches have been applied over time, but during the past 25 years, there has been a general trend towards the use of human biomonitoring. A few studies have used human biomonitoring methodology to track contact allergens together with information on patch test reactivity. Hypothetically, the internal load of reactive chemicals might modify the immune response to haptens and the propensity to sensitize and elicit allergic contact dermatitis or develop tolerance. This review offers a general overview of human biomonitoring, including information about its typical application and methodology. Furthermore, studies that have attempted to perform simultaneous biomonitoring and patch testing are reviewed. It is concluded that all studies conducted until the present have focused on one or two routes of exposure (typically skin and oral exposure, but also skin and airway exposure), whereas no studies have investigated all routes at the same time. Also, there is a need for prospective studies, as all epidemiological studies so far have been cross-sectional.

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Nickel excretion in urine after oral administration*

Cited by 17 publications

References 10 publications

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

Urinary nickel: measurement of exposure by inductively coupled plasma argon emission spectrometry

Contact allergy and human biomonitoring - an overview with a focus on metals

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