Nickel (II) and cobalt (II) complexes with bidentate nitrogen-sulfur donor pyrazole derivative ligands: Syntheses, characterization, X-ray structure, electrochemical studies, and antibacterial activity

Soltani, Behzad; Ghorbanpour, Monireh; Ziegler, Christopher J.; Ebadi, Mostafa; Mohammad‐Rezaei, Rahim

doi:10.1016/j.poly.2020.114423

Cited by 28 publications

(19 citation statements)

References 54 publications

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“…Designed molecules bearing these atoms provide advantages in binding to urease, since urease is the nickel-containing enzyme. [18] From this point of view, in this study, new pyrazoline derivatives bearing benzo[d]thiazol-2(3H)-one moiety were synthesized and their evaluation for inhibitory activity against Jack bean urease with in vitro and in silico studies.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Evaluation and in Silico Studies of New Pyrazoline Derivatives Bearing Benzo[d]thiazol‐2(3H)‐one Moiety as Potential Urease Inhibitors

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Baltaş

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et al. 2022

Chemistry & Biodiversity

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Novel pyrazoline derivatives containing benzo [d]thiazol-2(3H)-one moiety were synthesized and screened for their inhibitory properties against urease, a clinically important metabolic enzyme. In vitro enzyme inhibition studies revealed that all pyrazolines (7.21-87.77 μM) were more potent than the standard inhibitor acetohydroxamic acid (251.74 μM) against the urease enzyme. Most notably, compound 2m, which is more active than the other compounds in vitro and molecular docking studies, showed a significant inhibition potential and efficient IC 50 values (7.21 � 0.09 μM) and in silico inhibition constant (0.11 μM). Furthermore, molecular dynamics (MD) simulation analysis suggests that the binding stability of urease enzyme and compound 2m were stably maintained during the 100 ns simulation time. Compound 2m also exhibited good physicochemical and pharmacokinetic parameters. The overall results of urease inhibition have indicated that these pyrazoline derivative compounds can be further optimized and developed for the discovery of novel urease inhibitors.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Evaluation and in Silico Studies of New Pyrazoline Derivatives Bearing Benzo[d]thiazol‐2(3H)‐one Moiety as Potential Urease Inhibitors

Tok

Baltaş

Tatar

et al. 2022

Chemistry & Biodiversity

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“…Several other mixed ligands complexes with anthranilic acid were reported to have antifungal and antibacterial potential [11]. Metal complexes consisting of chelating ligands of N (nitrogen) and S (sulfur) have attracted great interest [12] due to their interesting physical and chemical properties, apparent biological activities, and models of metallic enzyme active sites. N and S atoms are known to play a major role in coordinating minerals into the active sites of many vital mineral molecules.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, thermal analysis and biological study of new thiophene derivative containing o-aminobenzoic acid ligand and its Mn(II), Cu(II) and Co(II) metal complexes

Refat¹,

Altalhi²,

Al‐Hazmi³

et al. 2021

Bull. Chem. Soc. Eth.

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New ligand containing 2-(2,4-dioxo-4-thiophen-2-yl-butyrylamino)-benzoic acid (HL) merged moiety was synthesized and characterized by FT-IR, elemental analyses, mass spectra and 1H-NMR spectral. In the present study, the attempts were carried to form complexes of HL ligand with some transition metal ions (MnII, CuII and CoII) of well-defined at the (1:1) ratio of the components in the dimethyl sulfoxide (DMSO) solvent. All complexes have been studied by FTIR spectra, elemental analyses, thermal analysis, molar conductivity, electronic spectra and magnetic moment. The HL ligand produced as a bidentate chelate with interactive metal ions. All the results suggested octahedral geometry to complexes and have the formulae [M(HL)(Cl)2(H2O)2].nH2O where M = Mn(II), Cu(II) and Co(II). The IR spectra of the complexes were assigned and compared with the data in literature. The kinetic and thermodynamic results such as E*, ΔH*, ΔS* and ΔG* were calculated based o the TGA/DTG curves using Coats and Redfern and Horowitz and Metzger approximation methods. Furthermore, the resultant complexes were evaluated for the anti-bacterial and anti-fungal potential. KEY WORDS: 2-(2,4-Dioxo-4-thiophen-2-yl-butyrylamino)-benzoic acid, Transition metal complexes, FTIR, TGA, Antimicrobial test Bull. Chem. Soc. Ethiop. 2021, 35(1), 129-140. DOI: https://dx.doi.org/10.4314/bcse.v35i1.11

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“…Due to diverse bio-activities, pyrazole moiety with different derivatives is on the list of studies of many researchers in medicinal chemistry [16][17][18][19][20] . Many researchers reported that coordination compound with pyrazole moiety with the different metal and various substituted pyrazole shows a long bio-activity list [21][22][23][24]. Experimental…”

Section: Introductionmentioning

confidence: 99%

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

Patel

Dhaduk

Dabhi

et al. 2021

Preprint

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A series of trisubstituted pyrazole-based ligands (L1-L6) and corresponding palladium(II) complexes were synthesized and characterized by conductivity measurement, 1H NMR, 13C NMR, Fourier Transform infrared (FT-IR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Synthesized compounds were screened for various biological activities. UV-Vis spectroscopy, viscosity measurement, fluorescence spectroscopy and molecular docking studies were used to determine the binding mode between HS-DNA and complexes, which suggest intercalation mode of binding. The protein binding study of complexes was evaluated by UV-visible spectroscopy. Antibacterial study of the complexes was screened against two Gram (+ve) and three Gram (-ve) bacteria and results show that all complexes are more effective against microorganisms than their respective ligands. The cytotoxicity of the synthesized compounds was tested against brine shrimp and MCF-7 Cells. The LC50 values of the ligand and complexes were found in the range of 9.24-4.12 µg/mL and 5.68-7.94 µg/mL, respectively.

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Nickel (II) and cobalt (II) complexes with bidentate nitrogen-sulfur donor pyrazole derivative ligands: Syntheses, characterization, X-ray structure, electrochemical studies, and antibacterial activity

Cited by 28 publications

References 54 publications

Synthesis, Biological Evaluation and in Silico Studies of New Pyrazoline Derivatives Bearing Benzo[d]thiazol‐2(3H)‐one Moiety as Potential Urease Inhibitors

Synthesis, Biological Evaluation and in Silico Studies of New Pyrazoline Derivatives Bearing Benzo[d]thiazol‐2(3H)‐one Moiety as Potential Urease Inhibitors

Synthesis, characterization, thermal analysis and biological study of new thiophene derivative containing o-aminobenzoic acid ligand and its Mn(II), Cu(II) and Co(II) metal complexes

Heteroleptic C, N- Donor Pd(II) Complexes: Synthesis, Characterization, DNA/BSA Binding Interactions And Biological Studies

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