Nickel(II) and copper(II) complexes of 2,2’‐bibenzo[d]thiazole: Synthesis, characterisation and biological studies

Abstract

Benzothiazole moiety has gained a lot of attention because of its importance as essential pharmacophore in the development of metal based drugs. Nickel (II) and copper(II) complexes of a benzothiazole based ligand, 2,2'-bibenzo[d]thiazole (L 1 ), synthesized by the reaction of benzothiazole-2-carbonylchloride and o-aminothiophenol, is reported. The compounds were characterised by elemental and percentage metal analyses, spectroscopic (FTIR and UV-vis), 1 H and 13 C NMR, Mass spectra, thermal, magnetic moment and molar conductance analyses. The mass spectra, elemental and percentage metal composition of the metal complexes gave a 2:1 ligand to metal stoichiometric mole ratio. The spectral data showed that the ligand was coordinated to the metal ions through the nitrogen atoms of the benzothiazole moiety. The electronic spectra and magnetic susceptibility measurements showed that the nickel and copper complexes adopted square planar geometries. The ligand and its metal(II) complexes were screened against some drug resistant microbes and were found to exhibit varied degree of antimicrobial activities. The nickel complex was more active compared to ciprofloxacin against Staphylococcus aureus and Bacillus cereus. Similarly, the antioxidant potential of the ligand was evaluated. The ligand is a better ferrous ion chelating agent compared to 1,10-phenanthroline and 2,2-bipyridine. The ligand and its complexes exhibited good antimicrobial and Fe 2+ chelating properties making them probable compounds of interest in antibiotic and antioxidant drug researches.

Corrosion Resistance of Aluminum against Acid Activation: Impact of Benzothiazole-Substituted Gallium Phthalocyanine

“…After corrosion, these vibrational signals disappeared which indicates good BTThio/aluminum adsorption interaction. The assignment of 751 cm −1 to C–S–C vibration is consistent with the report of Omaka and co-workers [51] for benzothiazole moiety. The disappearance of this signal after corrosion is a good indication that corrosion inhibition by BTThio is due to adsorption onto metal surface.…”

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

“…In the case of the free ligand, lower antimicrobial activity was presented against the test microbes; an inhibition halo of 7-12 mm for bacteria and 7-10 mm for fungi was obtained, but there was no effect on P. aeruginosa and S. aureus. The MIC value of the free ligand was in the range of 80-100 µg/mL for both microorganisms, and that of Btz-06 was in the range of 10-90 µg/mL for bacteria and 30-100 µg/mL for fungi [116].…”

Green Synthesis of 2,2'-Bibenzazole and Its Polymers by Using Hexachloroacetone as C2 Synthon

“…六氯丙酮简单易得, 反应后易于分离, 常用作氯离 子的提供试剂, 用于烯胺的氯化 [1] 以及糖半缩醛的无溶 剂氯化 [2] , 或者用作三氯甲酰化试剂, 在中性条件下制 备三氯乙酰胺和三氯乙酸酯 [3] , 也可以和二甲基亚砜 (DMSO)一起用作氧化剂, 如用于卞醇的氧化 [4] . 联苯并噻唑作为一类二齿配体, 能与一系列的无机 金属离子进行配位 [5] . 此外, 与一系列含氮类杂环化合 物一样 [6] , 它也具有一定的生物活性 [7] .…”

“…以联苯并噻唑 作为重复结构单元的聚苯并噻唑, 不仅是一类具有光电 活性的红色荧光材料 [8] , 还是一种耐高温耐化学氧化和 尺寸稳定性的高性能材料 [9] . 联苯并噻唑的制备一般通 过使用 2 位取代的苯并噻唑和一分子的邻氨基苯硫醇进 行反应, 比如使用 2-甲酰氯苯并噻唑 [10] 和 2-醛基苯并噻 唑 [11] , 但是这两种底物的获取均不方便, 也可以通过草 酸和邻氨基苯硫醇进行缩合 [12] . 对于苯并噻唑类聚合 物聚合物的制备, 实验室常用二元酸和 2,5-二氨基对苯 二硫醇进行缩聚, 这种制备方法要求较高的反应温度和 强酸性的反应溶剂.…”