Nickel(II)-PPh3 complexes with ONS and ONN chelating thiosemicarbazones: synthesis and inhibition potential on influenza A viruses

Abstract

Tetra-coordinated nickel(II) complexes of two ONS (1, 2) and seven ONN (3a-3g) chelating 2-hydroxy-3-methoxy-benzaldehyde thiosemicarbazones were synthesized. The dibasic ligands and complexes bearing PPh 3 as a coligand were characterized by means of analytical and spectroscopic data. Cytotoxic activities of the ligands and nickel(II) complexes were determined using the MTT assay in vitro against MDCK cells, and then all the compounds were tested on influenza virus replication by plaque assays. The compounds showed GI 50 values varying from concentrations of 15.9 up to 161.8 µ g/mL for MDCK cells. The plaque assays indicated that one ONS (1) and two ONN (3c and 3d) chelate structures have considerable antiviral effects on influenza A viruses at lower concentrations than the GI 50 values for MDCK cells. The ligands and other complexes did not show any inhibitory effects on influenza virus plaque formation. The effects of the compounds on the influenza virus and structure-antiviral activity relationships were discussed based on the donor atoms and S-alkyl substituents.

Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives

“…The electronic absorption spectra of the new bis(thiosemicarbazones) based on Schiff base derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) show that in all obtained products absorption bands appeared in the range of 256-406 nm in dimethylsulfoxide (see Figures S28-S36 in compound 1 (258 nm). This transition is a characteristic benzenoid (B) band of the aromatic structure [32].…”

“…and 111.4 ppm and those from the terephthalaldehyde ring (C9-C10) were observed between 141.1 and 128.2 ppm. The characteristic -C=N (C8) peaks of imine were observed at 144.1 and 141.0 ppm for all compounds(1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The other remarkable characteristic, -C=S (C7) peaks of the thiosemicarbazone region, were observed at 178.1 and 175.6 ppm for all compounds (1-10).…”

“…They are used as versatile intermediates for synthesizing numerous moieties as well. Thiosemicarbazones have shown numerous medicinal properties and biological activities such as anticonvulsant [1], antituberculosis [2], urease inhibitory [3], anticancer [4], antiviral [5], antimicrobial [1], antibacterial [6], and antioxidant activity [7][8][9][10][11].…”

“…In the compounds(1)(2)(3)(4)(5)(6)(7)(8)(9), the aromatic C signals of the aryl ring (C1-C6) were observed between 163 4. and 111.4 ppm and those from the terephthalaldehyde ring (C9-C10) were observed between 141.1 and 128.2 ppm.…”

Inhibition of DNase I Enzyme with Nickel(II) Triphenylphosphine Complexes Incorporating Tridentate Schiff Base Ligands in Vitro

“…Mixed-thiosemicarbazones complexes bearing seconder ligand play essential roles in biological processes like activation of enzymes by metals (5)(6). Particularly thiosemicarbazone-based nickel(II) complexes have shown significant antiviral (7), antibacterial (8) and anticancer activities (9). Investigations on interactions of DNA and thiosemicarbazone molecules have attracted significant attention over the last years (10).…”