2015
DOI: 10.1371/journal.pone.0119428
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Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability

Abstract: Nickel (Ni) ions easily elute from many alloys and elicit inflammation and allergies. Previous studies have shown that infections due to the implantation of medical devices cause inflammation and enhance the elution of Ni ions (Ni2+). However, cross-talk between infection- and Ni2+-induced signaling pathways has not yet been elucidated in detail. In the present study, we investigated the effects of Ni2+ on the lipopolysaccharide (LPS)-induced production of cytokines in a LPS-induced air pouch-type inflammation… Show more

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Cited by 11 publications
(18 citation statements)
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“…These data indicate that nickel interferes with macrophages' L-arginine/NOS system on multiple levels. Asakawa et al (2015) also studied the effects of nickel (II) on the LPS-induced production of cytokines in murine macrophage cell line RAW264, as well as in the air pouch-type inflammation model in BALB/c mice. Nickel (II) inhibited LPS-induced production of IL-6, but not that of tumour necrosis factor-a (TNF-a) both in vivo and in vitro.…”
Section: Immunotoxic Activity Of Nickelmentioning
confidence: 99%
“…These data indicate that nickel interferes with macrophages' L-arginine/NOS system on multiple levels. Asakawa et al (2015) also studied the effects of nickel (II) on the LPS-induced production of cytokines in murine macrophage cell line RAW264, as well as in the air pouch-type inflammation model in BALB/c mice. Nickel (II) inhibited LPS-induced production of IL-6, but not that of tumour necrosis factor-a (TNF-a) both in vivo and in vitro.…”
Section: Immunotoxic Activity Of Nickelmentioning
confidence: 99%
“…It inhibits pathogen growth and survival through deprivation of indispensable micronutrients, generates host protective Fenton-reaction-dependent reactive oxygen species and affords nonspecific inhibition of bacterial protein binding [13]. Importantly, internalized micronutrients also help orchestrate vital signaling pathways [36]. Zinc is an essential micronutrient utilized in host defense.…”
Section: Introductionmentioning
confidence: 99%
“…The B. mori hemocyte extract is expected to contain numerous hemocyte-derived bioactive peptides. Activation of TLR4 by LPS is known to initiate signaling events and induce the secretion of pro-inflammatory cytokines and antimicrobial peptides ( 34 , 44 ). These proteins evoke inflammation by activating neutrophils, macrophages and dendritic cells ( 44 ).…”
Section: Discussionmentioning
confidence: 99%
“…Activation of TLR4 by LPS is known to initiate signaling events and induce the secretion of pro-inflammatory cytokines and antimicrobial peptides ( 34 , 44 ). These proteins evoke inflammation by activating neutrophils, macrophages and dendritic cells ( 44 ). LPS stimulation has also been shown to induce the production of PGE2, IL-1β, IL-6, TNF-α and other cytokines in the air-pouch inflammation model ( 44 46 ).…”
Section: Discussionmentioning
confidence: 99%
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