Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma

Rahimi, Shabnam; Naserzadeh, Parvaneh; Mousavi, Zahra; Ashtari, Khadijeh; Seydi, Enayatollah; Pourahmad, Jalal

doi:10.1002/jbt.22376

Cited by 6 publications

(4 citation statements)

References 52 publications

(79 reference statements)

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“…[38] Our results show a collapse in MMP in OSCC mitochondria exposed to SPIONs, which is in agreement with previous studies showing, that SPIONs and other NPs have the potential to collapse in MMP. [19,39] In addition, collapse in the MMP is considered as one of the consequences of the increase in the level of ROS. In the following, we assessed mitochondrial swelling and cytochrome c release.…”

Section: Discussionmentioning

confidence: 99%

The selective toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) on oral squamous cell carcinoma (OSCC) by targeting their mitochondria

Afrasiabi

Seydi

Rahimi

et al. 2021

J Biochem & Molecular Tox

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In recent years, many researchers have made tremendous efforts into using nanotechnology in biomedical applications and science, such as magnetic resonance imaging, drug delivery, and in particular, oncological therapeutic via superparamagnetic iron oxide nanoparticles (SPIONs). Head and neck squamous cell carcinoma (HNSCC) and especially oral squamous cell carcinoma (OSCC) have been a serious and ongoing concern. There are many strong emphases on the importance

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Section: Discussionmentioning

confidence: 99%

The selective toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) on oral squamous cell carcinoma (OSCC) by targeting their mitochondria

Afrasiabi

Seydi

Rahimi

et al. 2021

J Biochem & Molecular Tox

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“…According to our study, NiONPs‐triggered ferroptosis is associated with elevation of lipid peroxidation, depletion of GSH and downregulation of GPX4. Consistently, increased ROS level, lipid peroxidation and mitochondrial membrane potential have been detected on skin mitochondria isolated from mouse melanoma exposed to NiONPs 29 . Exposing HUVECs to NiONPs results in intracellular iron accumulation, which is a sign of pro‐ferroptotic effects 30 .…”

Section: Discussionmentioning

confidence: 68%

“…Consistently, increased ROS level, lipid peroxidation and mitochondrial membrane potential have been detected on skin mitochondria isolated from mouse melanoma exposed to NiONPs. 29 Exposing HUVECs to NiONPs results in intracellular iron accumulation, which is a sign of pro-ferroptotic effects. 30 In addition, Di Bucchianico et al have demonstrated the participation of iron in NiONPs-induced genome instability and cytotoxicity by showing that iron chelator protected against NiONPs-induced chromosomal and cellular damage.…”

Section: Discussionmentioning

confidence: 99%

Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3

Liu

Cheng

et al. 2022

Environmental Toxicology

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Exposure to nickel oxide nanoparticles (NiONPs), which have been widely produced and applied in industry, leads to adverse pulmonary and systemic effects. The aim of this study is to investigate the involvement of apoptosis and ferroptosis in NiONPsinduced acute lung injury (ALI). Intratracheal instillation of NiONPs into mice elevated the levels of pro-inflammatory cytokines, neutrophils, and proteins in the bronchoalveolar lavage fluid, and triggered apoptosis and ferroptosis in the lung tissues. Consistently, NiONPs-induced apoptosis and ferroptosis were observed in in vitro experiments using human lung epithelial cells. Activating transcription factor 3 (ATF3), a stress-inducible transcription factor, was upregulated by NiONPs exposure in both murine lung tissues and human lung epithelial cells. Moreover, human lung epithelial cells with ATF3 deficiency exhibited a lower level of apoptosis and ferroptosis when exposed to NiONPs. Collectively, our findings demonstrated that ATF3 was responsive to NiONPs exposure, and promoted NiONPs-induced apoptosis and ferroptosis in lung epithelial cells, indicating that ATF3 is a potential biomarker and therapeutic target for NiONPs-associated ALI.

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“…NiO-NPs could notably induce optional cytotoxicity on malignant cutaneous melanoma (MCM) mitochondria. Therefore, this compound can be considered a favorable candidate for further in vivo and clinical studies to achieve a novel antimalignant melanoma medicine [ 127 ].…”

Section: Nanotechnology (Metallic and Related Nps) Are Significant To...mentioning

confidence: 99%

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Marzi

Osanloo

Vakil

et al. 2022

BioMed Research International

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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.

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Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma

Cited by 6 publications

References 52 publications

The selective toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) on oral squamous cell carcinoma (OSCC) by targeting their mitochondria

The selective toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) on oral squamous cell carcinoma (OSCC) by targeting their mitochondria

Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

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