Nickel release from nickel‐plated metals and stainless steels

Haudrechy, P.; Foussereau, J; Mantout, B.; Baroux, B.

doi:10.1111/j.1600-0536.1994.tb01997.x

Cited by 87 publications

(58 citation statements)

References 8 publications

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“…Many publications have been centred on the release of metallic particles and their serum or blood dosage [20][21][22][23][24][55][56][57][58][59][60][61][62]. But, the numbers studied are often low and the follow-up short.…”

Section: Discussionmentioning

confidence: 99%

Second generation of metal-on-metal cemented total hip replacements: 12 years of clinical and biological follow-up

et al. 2007

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The second generation of metal-on-metal prostheses appeared at the end of the 1980's as a serious alternative to metal on polyethylene bearing couples. Short-term clinical results were promising; however certain questions remain concerning clinical, radiological and biological aspects. Release of chromium and cobalt from the bearing couple is one of these aspects. The aim of this study is to analyse the results of a series of 97 cemented total hip prostheses comprising a titanium femoral stem and the Metasul ® metal-metal bearing couple. Mean follow-up was nine years (7-12 years). Complications were marked by 12 revisions, out of which two were for recurrent early dislocations, eight for clinical and radiological failure, and two for worrying radiological alterations. During these revisions, we observed a serious infiltration of metal debris four times, leading to an alternative strategy using an alumina-alumina bearing couple. Three more revisions are planned for rapidly evolving radiological alterations. Thirty implants showed radiological signs of preoccupying deterioration on the acetabular side. Eight segmentary femoral osteolysis have been observed. Twelve patients suffer from recurrent subluxation. Concerning the global evolution of metal serum levels, cobalt remains stable after five years. The values are three to four times above those of a non-exposed subject, but largely below toxic ratios. The evolution of serum chromium levels is similar to cobalt. Implantation of two prostheses in one same patient leads to significant increase in serum metal ratios. This series raises questions concerning the reliability of the metal-onmetal bearing couple. Osteolysis is an unsolved problem. Today, cemented fixation is debatable although this series doesn't allow this parameter to be held directly responsible. Nothing points to any shortcomings concerning the taper fixation or the metallurgy of the femoral stem. The study of the serum metal levels seems a good indicator of the impingement situations and the functioning of the bearing couple.

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Section: Discussionmentioning

confidence: 99%

Second generation of metal-on-metal cemented total hip replacements: 12 years of clinical and biological follow-up

et al. 2007

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“…The metallic inserts of the Optiva*2 and the Vasofix Certo come in contact with the fluid passing through them. The metallic insert of the Optiva*2 catheter obviously consisted of nickel-plated brass, which has inferior corrosion properties [22]. The insert of the Vasofix Certo catheter has a composition indicating that it is made from stainless steel, which is more corrosion resistant.…”

Section: Discussionmentioning

confidence: 99%

Nickel contamination from an intravenous catheter used for infusion

Høl¹,

Bell²,

Mølster³

et al. 2005

Scandinavian Journal of Clinical and Laboratory Investigation

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At the outset of a clinical research project involving metal analyses on patients receiving metal devices in conjunction with hip fractures, unexpected high concentrations of nickel were discovered in serum samples taken before surgery. The median nickel concentration in 30 patients was 4.6 microg/l (highest 19.5 microg/l), while reference values in non-exposed persons are reported to be 0.05-1.2 microg/l. The sampling and analyzing procedures were scrutinized without positive identification of the source of contamination. A review of all relevant procedures was then undertaken. It was identified that the nickel contamination originated from the intravenous catheter which was always put in place immediately after the patient's admission to the hospital, and thus before the blood sampling. Close inspection of the intravenous catheter revealed that it contained a nickel-plated brass funnel inside the hub of the device which released nickel into the Ringer-acetate passing through the catheter. The present catheter has been the standard device used at Haukeland University Hospital for the past 6 years. Patients have consequently been exposed to small amounts of nickel. The clinical relevance of the exposure cannot be determined. For the patients included in the research project, a metal-free alternative was used. These findings show that the quality and properties of everyday medical devices should be scrutinized, at least before being used for special purposes.

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“…The composition specification requirement of AISI 316L is illustrated in table 4. This composition is designed to decrease the risk of nickel ion release [10]. Indeed, the calculated rate of nickel release in our study was !0.05 Ìg/cm 2 /week which is actually undetectable by ICP-OES.…”

Section: Discussionmentioning

confidence: 99%

“…This stainless-steel alloy has a low sulphur content, and molybdenum is added to increase its hardness and resistance to corrosion [10]. The composition specification requirement of AISI 316L is illustrated in table 4.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have investigated the relationship between nickel release from stainless-steel alloys and reactivity in nickel-sensitive patients as determined by patch testing. High-grade stainless steel has an increased resistance to corrosion and releases nickel in quantities that can hardly be detected [9][10][11]. The aim of the present study was to determine the reactivity of nickel-sensitive subjects to AISI 316L stainless-steel ear piercing post assemblies.…”

Section: Introductionmentioning

confidence: 99%

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AISI 316L Stainless-Steel Ear Piercing Post Assembly Does Not Cause Dermatitis in Nickel-Sensitive Subjects

Ingber¹,

Hershko²,

Horev³

2003

Exog Dermatol

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Twenty-three female and 2 male subjects, documented to be sensitive to nickel by history and diagnostic patch testing, were pierced with American Iron Steel Institute (AISI) 316L stainless-steel ear piercing post assemblies (The Ear Piercing Manufacturers of Europe, UK), AISI 316L having a specification that includes a nickel content of between 10 and 14%. After piercing, the subjects were examined on days 7, 14, 30 and 42. Seven of the ear piercing post assemblies collected at random from the subjects at the end of the study and 10 unused post assemblies selected at random were analysed for nickel content and release. None of the nickel-sensitive patients showed signs of nickel dermatitis during the study. The nickel content of the ear piercing post assemblies collected from patients was reported as being between 11.5 and 12.9%, and the calculated rate of nickel release was below the detection limit of the method, thus recorded at <0.05 µg/cm²/week. By comparison, the nickel content of the unused post assemblies was reported to be between 9.93 and 10.5%, and the calculated rate of nickel release was between 0.11 and 0.21 (mean: 0.15) µg/cm²/week. These results suggest that the AISI 316L stainless-steel ear piercing post assemblies do not elicit adverse reactions to nickel in previously sensitized subjects.

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Nickel release from nickel‐plated metals and stainless steels

Cited by 87 publications

References 8 publications

Second generation of metal-on-metal cemented total hip replacements: 12 years of clinical and biological follow-up

Second generation of metal-on-metal cemented total hip replacements: 12 years of clinical and biological follow-up

Nickel contamination from an intravenous catheter used for infusion

AISI 316L Stainless-Steel Ear Piercing Post Assembly Does Not Cause Dermatitis in Nickel-Sensitive Subjects

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