2018
DOI: 10.1111/bph.14182
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Niclosamide inhibits vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia in injured rat carotid arteries

Abstract: Niclosamide inhibited vascular smooth muscle cell proliferation and migration and attenuated neointimal hyperplasia in balloon-injured rat carotid arteries through a mechanism involving inhibition of STAT3.

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Cited by 29 publications
(27 citation statements)
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“…The results from Transwell assay were consistent with scratch wound assay (Figure E,F). To further evaluate the mechanism of inhibitory effects on migration, we measured the activity and expression of MMP2 and MMP9, which are involved in VSMC migration via the degradation of extracellular matrix . The increasing expression of PDGF‐BB–stimulated MMP2 was inhibited by TQ (15 μmol/L) treatment but not MMP9 (Figure A).…”
Section: Resultsmentioning
confidence: 99%
“…The results from Transwell assay were consistent with scratch wound assay (Figure E,F). To further evaluate the mechanism of inhibitory effects on migration, we measured the activity and expression of MMP2 and MMP9, which are involved in VSMC migration via the degradation of extracellular matrix . The increasing expression of PDGF‐BB–stimulated MMP2 was inhibited by TQ (15 μmol/L) treatment but not MMP9 (Figure A).…”
Section: Resultsmentioning
confidence: 99%
“…To further elucidate the mechanism of inhibitory effects on migration, we measured the activity and expression of MMP2 and MMP9, which can break down most components of the extracellular matrix and are positively correlated with the degree of migration (Xiao et al. 2018 ). The increasing expression of PDGF-BB stimulated MMP2 and MMP9 was inhibited by SIL and XMA treatment ( Figure 3(F–H) ).…”
Section: Resultsmentioning
confidence: 99%
“…Endothelial proliferation itself may stimulate the proliferation and migration of SMCs. It was previously suggested that the STAT3, adenosine monophosphate-activated protein kinase, Akt and Wnt/β-catenin signaling pathways, as well as mitochondrial uncoupling, are involved in neointimal hyperplasia ( 32 ). In line with this, the present study indicated that the AMSC in co-culture exerted a greater inhibitory effect on SMC migration compared with that of GMSCs as AMSCs secreted a greater variety of cytokines than GMSCs.…”
Section: Discussionmentioning
confidence: 99%