Nicorandil‐induced colovesical fistula in a patient with diverticular disease

Noyes, James D.; Mordi, Ify; Zeb, Qaiser; Lang, Chim C.

doi:10.1002/ccr3.3888

Cited by 4 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although nicorandil can induce headaches with mild to moderate severity, it was generally well tolerated in clinical trials 40 . However, nicorandil may also cause gastrointestinal ulcers, fistulation 41 , and oral ulceration 42 . The release of inflammatory NO in the intestinal mucosa has been postulated as the mechanism of fistulation 43 .…”

Section: Discussionmentioning

confidence: 99%

Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database

Jouta²,

Hosomi³

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Microscopic colitis (MC) is a chronic inflammatory bowel disease that is characterized by nonbloody watery diarrhea. The epidemiology in Japan differs from that in Europe and the United States, but little information is available from epidemiological surveys of MC in Japan. This study aimed to provide a new hypothesis regarding the factors associated with MC by using the Japanese Adverse Drug Event Report (JADER) database. “Colitis microscopic” (preferred term code: 10056979) cases entered into the JADER database between 2004 and 2021 were analyzed. Of the 246,997 cases in the JADER database, 161 cases were observed to be associated with MC. A Weibull analysis revealed that the median onset duration of MC (interquartile range) was 72.5 (36.0‒125.5) days in lansoprazole users and 116.0 (60.3‒1089.0) days in aspirin users. A multiple logistic regression analysis revealed that MC was significantly associated with the female sex, as well as ages ≥ 60 years and drugs including lansoprazole, aspirin, and nicorandil. A subset analysis revealed that MC was positively associated with obesity in female cases. Our study cannot demonstrate a causal inference between MC and each drug; however, the findings suggest that MC was associated with nicorandil as well as with lansoprazole and aspirin.

show abstract

Section: Discussionmentioning

confidence: 99%

Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database

Jouta²,

Hosomi³

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The patient developed multiple fistulas between his bladder and rectum, requiring major surgery with subsequent urosepsis admissions, resulting in long term catheter use. The individual remained on nicorandil therapy for 7 years before the connection was made between nicorandil and his symptoms, which resulted in a change of his anti-anginal medication [29].…”

Section: Polygenic Risk Scoresmentioning

confidence: 99%

Precision Medicine and Adverse Drug Reactions Related to Cardiovascular Drugs

et al. 2021

Self Cite

View full text Add to dashboard Cite

Cardiovascular disease remains the leading global cause of death. Early intervention, with lifestyle advice alongside appropriate medical therapies, is fundamental to reduce patient mortality among high-risk individuals. For those who live with the daily challenges of cardiovascular disease, pharmacological management aims to relieve symptoms and prevent disease progression. Despite best efforts, prescription drugs are not without their adverse effects, which can cause significant patient morbidity and consequential economic burden for healthcare systems. Patients with cardiovascular diseases are often among the most vulnerable to adverse drug reactions due to multiple co-morbidities and advanced age. Examining a patient’s genome to assess for variants that may alter drug efficacy and susceptibility to adverse reactions underpins pharmacogenomics. This strategy is increasingly being implemented in clinical cardiology to tailor patient therapies. The identification of specific variants associated with adverse drug effects aims to predict those at greatest risk of harm, allowing alternative therapies to be given. This review will explore current guidance available for pharmacogenomic-based prescribing as well as exploring the potential implementation of genetic risk scores to tailor treatment. The benefits of large databases and electronic health records will be discussed to help facilitate the integration of pharmacogenomics into primary care, the heartland of prescribing.

show abstract

Nicorandil

2021

Reactions Weekly

View full text Add to dashboard Cite

Nicorandil‐induced colovesical fistula in a patient with diverticular disease

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 15 publications

Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database

Adverse event profiles of microscopic colitis in the Japanese Adverse Drug Event Report (JADER) database

Precision Medicine and Adverse Drug Reactions Related to Cardiovascular Drugs

Nicorandil

Contact Info

Product

Resources

About