Nicotina y modelos animales: ¿qué nos aporta el paradigma de enriquecimiento ambiental?

Environmental enrichment (EE) is an experimental paradigm in which rodents are housed in complex environments containing objects that provide stimulation, the effects of which are expected to improve the welfare of these subjects. EE has been shown to considerably improve learning and memory in rodents. However, knowledge about the effects of EE on social interaction is generally limited and rather controversial. Thus, our aim was to evaluate both novel object recognition and agonistic behavior in NMRI mice receiving EE, hypothesizing enhanced cognition and slightly enhanced agonistic interaction upon EE rearing. During a 4-week period half the mice (n = 16) were exposed to EE and the other half (n = 16) remained in a standard environment (SE). On PND 56-57, animals performed the object recognition test, in which recognition memory was measured using a discrimination index. The social interaction test consisted of an encounter between an experimental animal and a standard opponent. Results indicated that EE mice explored the new object for longer periods than SE animals (P < .05). During social encounters, EE mice devoted more time to sociability and agonistic behavior (P < .05) than their non-EE counterparts. In conclusion, EE has been shown to improve object recognition and increase agonistic behavior in adolescent/early adulthood mice. In the future we intend to extend this study on a longitudinal basis in order to assess in more depth the effect of EE and the consistency of the above-mentioned observations in NMRI mice.

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Environmental Enrichment Improves Novel Object Recognition and Enhances Agonistic Behavior in Male Mice

Mesa-Gresa

Pérez-Martínez

Redolat

2013

Aggressive Behavior

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Behavioral impact of experience based on environmental enrichment: Influence of age and duration of exposure in male NMRI mice

Mesa-Gresa

Ramos-Campos

Redolat

2021

Developmental Psychobiology

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Prior studies have suggested that short periods of exposure to environmental enrichment (EE) in rodents induce physiological and behavioral effects. In the present study, our aim was to evaluate if the impact of experiences based on EE could be modulated by the age of onset and the developmental period of exposure. NMRI male mice (n = 64) were exposed to EE or standard environment (SE) and behavioral changes (anxiety, exploration, memory and social interaction) were evaluated.

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Behavioral effects of different enriched environments in mice treated with the cholinergic agonist PNU-282987

Mesa-Gresa

Ramos-Campos

Redolat

2014

Behavioural Processes

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Nicotina y modelos animales: ¿qué nos aporta el paradigma de enriquecimiento ambiental?

Cited by 5 publications

References 43 publications

Environmental Enrichment Improves Novel Object Recognition and Enhances Agonistic Behavior in Male Mice

Environmental Enrichment Improves Novel Object Recognition and Enhances Agonistic Behavior in Male Mice

Behavioral impact of experience based on environmental enrichment: Influence of age and duration of exposure in male NMRI mice

Behavioral effects of different enriched environments in mice treated with the cholinergic agonist PNU-282987

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