Nicotinamide Adenine Dinucleotide Synthesis by Mycobacterium tuberculosis van bovis.

Dudley, Mary A.; Willett, Hilda Pope

doi:10.3181/00379727-119-30307

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C~klfz~rcs and Extract I'repcrratioaz1

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1966

1972

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Cited by 9 publications

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“…volume before i t was applied to a 0.8 X 55 cm Dowex-1-formate, AG X 8 column. The column was developed with a gradient of 0 to 4 IV formic acid as outlined previously (1). Each 265-rnp peak eluted frorn the colurnn was lyophilized, dissolved in 0.5 rnl of distilled writer, and analyzed.…”

Section: C~klfz~rcs and Extract I'repcrratioazmentioning

confidence: 99%

Comparison of Nicotinamide Adenine Dinucleotide Synthesis by Mycobacterium Tuberculosis and Mycobacterium Bovis

Dudley¹,

Willett²

1966

Can. J. Microbiol.

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T'he RlR, strain of Jlr. tub~rcukosis utilized nicotiriic acid for the synthesis of nicotiilamide adenine dinucleotide (NAII). Nicotiriic acid moiionucleotide (KalLIN) and nicotinic acicl cliiiucleoticlc (NaAI)) were identified among the enzymatic reaction i~iixture products. A rorlaparisoil with J f . bnzis de~nonstrated a greater capacity for N:ID syntllesis by the bovine bacillus. I t has been hypothesizeci that reduced NAL) synthesis and failure to utilize intermediates which continue to be procl~nced are responsible for the excessive nicotinic acicl accuraulation by t u b e r c~~l n~i s .

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Section: C~klfz~rcs and Extract I'repcrratioazmentioning

confidence: 99%