Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

Snaidr, Victoria A.; Damian, Diona L.; Halliday, Gary M.

doi:10.1111/exd.13819

Cited by 86 publications

(58 citation statements)

References 58 publications

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“…NAM is a water-soluble form of Vitamin B3 (niacin) that can be found in animal and plant food, also as a cost-effective vitamin supplement [37][38][39]. It is absorbed in the stomach or intestine, metabolized in the liver, and excreted through the kidneys [40,41]. While its presence is vital for cellular energy metabolism, lack of NAM is associated with fatigue and anorexia.…”

Section: Nam Basic Principles and Metabolismmentioning

confidence: 99%

“…In contrast, high oral doses of NAM, especially above 6 g/day, have been associated with gastrointestinal toxicity [40]. Adverse effects such as flushing, hypotension or headache due to vasodilation are believed to be caused by nicotinic acid (another form of vitamin B3, also a NAD + precursor) rather than the NAM itself [39,41,47].…”

Section: Nam Basic Principles and Metabolismmentioning

confidence: 99%

“…The former depletes NAD + thus ATP and cellular energy; hence, UV-induced DNA damage is followed by defective DNA repair and genetic instability [40,47]. Immunosuppression induced by UV radiation is another carcinogenesis factor [41,[88][89][90]. This is obvious by the fact that cancer shows higher incidence in transplant recipients [91,92].…”

Section: Skinmentioning

confidence: 99%

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The Role of Nicotinamide in Cancer Chemoprevention and Therapy

2020

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Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism. Except for its role in the production of adenosine triphosphate (ATP), NAD+ acts as a substrate for several enzymes including sirtuin 1 (SIRT1) and poly ADP-ribose polymerase 1 (PARP1). Notably, NAM is an inhibitor of both SIRT1 and PARP1. Accumulating evidence suggests that NAM plays a role in cancer prevention and therapy. Phase III clinical trials have confirmed its clinical efficacy for non-melanoma skin cancer chemoprevention or as an adjunct to radiotherapy against head and neck, laryngeal, and urinary bladder cancers. Evidence for other cancers has mostly been collected through preclinical research and, in its majority, is not yet evidence-based. NAM has potential as a safe, well-tolerated, and cost-effective agent to be used in cancer chemoprevention and therapy. However, more preclinical studies and clinical trials are needed to fully unravel its value.

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Section: Nam Basic Principles and Metabolismmentioning

confidence: 99%

Section: Nam Basic Principles and Metabolismmentioning

confidence: 99%

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The Role of Nicotinamide in Cancer Chemoprevention and Therapy

2020

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“…The NIA treatment decreased TEWL values, increased the thickness of the SC, and larger and more mature corneocytes were found in the treated versus control sites. More recently, evidence from a phase 3 randomized clinical trial points to NIA having a role in the prevention of non-melanoma skin cancer [6,7]. The discovery and development of robust and accessible human skin surrogates continues to be an area of considerable interest to industry and regulatory authorities.…”

Section: Introductionmentioning

confidence: 99%

Topical Delivery of Niacinamide: Influence of Binary and Ternary Solvent Systems

Zhang¹,

Kung²,

Sil

et al. 2019

Pharmaceutics

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Niacinamide (NIA) is the amide form of vitamin B3 and has been widely used in pharmaceutical and personal care formulations. Previously, we reported a comparative study of NIA permeation from neat solvents using the Skin Parallel Artificial Membrane Permeability Assay (PAMPA) and mammalian skin. A good correlation between NIA permeation in the different models was found. In the present work, ten binary and ternary systems were evaluated for their ability to promote NIA delivery in the Skin PAMPA model, porcine skin and human epidermis. Penetration enhancement was evident for binary systems composed of propylene glycol and fatty acids in human skin studies. However, propylene glycol and oleic acid did not promote enhancement of NIA compared with other systems in the Skin PAMPA model. A good correlation was obtained for permeation data from Skin PAMPA and porcine skin. However, data from the Skin PAMPA model and from human skin could only be correlated when the PG-fatty acid systems were excluded. These findings add to our knowledge of the potential applications of Skin PAMPA for screening dermal/transdermal preparations.

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“…Nicotinamide (Nam; aka niacinamide, vitamin B3) has been used for decades in cosmetic and pharmaceutical products for the treatment of acne, skin photoaging attributes, and barrier integrity improvement [12][13][14]. It has been reported that Nam can protect cells from oxidative stress, UVinduced immunosuppression, and metabolic disruption [15][16][17]. Additionally, Nam has been shown to inhibit inflammatory cytokine induction by endotoxin in red blood cells [18].…”

mentioning

confidence: 99%

Nicotinamide (aka Niacinamide) Mitigates SASP-Related Inflammation Induced by Environmental Stressors in Human Epidermal Keratinocytes

Bierman¹,

Laughlin²,

Tamura³

et al. 2020

Preprint

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Daily exposure of skin to environmental stressors leads to molecular and morphological changes ascribed as premature aging. These stressors include solar radiation, industrial pollution, fossil fuel and carbon emissions, which cause cellular damage that induces an inflammatory response in skin. Several inflammatory components are known to be involved in triggering the senescence-associated secretory phenotype (SASP) which is known to accelerate aging. It is hypothesized that preventing induction of inflammation by environmental stressors can prevent premature aging. Since it is known that nicotinamide (Nam) has anti-inflammatory properties, we tested whether Nam can inhibit environmental stressor-induced inflammation. Exposure of keratinocytes to UVB, urban dust, diesel exhaust, and cigarette smoke extract stimulated production of the inflammatory mediators PGE2, IL-6, and IL-8 and induced gene expression patterns associated with apoptosis, DNA repair, and cell cycle control. In all cases, Nam treatment significantly inhibited these stress-induced responses. Nam also reduced IL-8 levels stimulated by the combination of topically applied particulate matter (PM2.5) and UV exposure in 3D skin equivalents. Under 5% 02 conditions that more closely mimic physiological 02 levels, Nam had a heightened inhibitory effect on UVB-induced PGE2 levels in keratinocytes. In a UV-challenge study, treatment with Nam reduced skin surface IL-1RA/IL-1 inflammatory biomarkers and erythema that were induced by solar simulated radiation. These findings provide a body of evidence that Nam can mitigate in part the skin's inflammatory response elicited by exposure to environmental stressors. This supports the potential that Nam can inhibit premature aging and help maintain skin's functionality and appearance.

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Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

Cited by 86 publications

References 58 publications

The Role of Nicotinamide in Cancer Chemoprevention and Therapy

The Role of Nicotinamide in Cancer Chemoprevention and Therapy

Topical Delivery of Niacinamide: Influence of Binary and Ternary Solvent Systems

Nicotinamide (aka Niacinamide) Mitigates SASP-Related Inflammation Induced by Environmental Stressors in Human Epidermal Keratinocytes

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