Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-κB and MAPK pathways

Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer

“…The above-mentioned additional effects concerning ceramide synthesis and anti-inflammation are cumulative. 29,45,46 To recruit enough patients that met the inclusion and exclusion criteria in a timely manner, and to avoid seasonal influences, six breast centers were selected for competitive recruitment. The high cumulative dropout rate of 23% in this study is mainly due to discontinuation of chemotherapy for medical reasons.…”

Therapeutic targeting of Toll-like receptors in cutaneous disorders

“…Zinc salt reduced TLR2 expression in P. acnes-treated keratinocytes in vitro [18]. Also, nicotinamide, inhibited of IL-8 production through NF-kB and MAPK pathways in keratinocytes in an in vitro study [19].…”

“…Imiquimod (R837) TLR7 agonist BCC, AK, SCC [89] Resiquimod (R848) TLR7/8 agonist AK [90] 852A TLR7 agonist Metastatic melanoma [91,110] Sotirimod (R850) TLR7 agonist AK [92] Loxoribine TLR7 agonist Skin cancer [93,94] Bropirimine TLR7 agonist Skin cancer [93,94] Pimecrolimus TLR2/6 agonist AD [95] Tacrolimus Down-regulation of TLR1, up-regulation of TLR2 AD [50] CpG ODN TLR9 agonist Wound healing [97] CpG 7907 TLR9 agonist BCC and metastatic melanoma [98] Poly (I:C) TLR3 agonist Melanoma [101] Nicotinamide TLR2 inhibition Acne vulgaris, bullous pemphigoid, necrobiosis lipoidica, dermatitis herpetiformis [19,94] Retinoic acid isotretinoin, adapalene…”

“…Nicotinamide has been effective in treating acne vulgaris through interaction with TLR2 and reducing IL-8 production in P. acnes-infected keratinocytes [19]. Other targeted skin diseases for nicotinamide are bullous pemphigoid, necrobiosis lipoidica and dermatitis herpetiformis [94].…”

Alternative Medicine in Pediatric Dermatology: What Is the Evidence?

“…Niacinamide has been shown to significantly decrease P. acnes-stimulated cytokine production in keratinocytes by blocking activation of MAPK and NF-κB pathways [37]. Clinical studies have also evaluated the efficacy of niacinamide in the treatment of acne.…”