2018
DOI: 10.1007/s40199-018-0221-5
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Nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in Alzheimer’s disease animal model by reducing Tau hyperphosphorylation

Abstract: BackgroundNicotinamide is considered to be effective in halting the Alzheimer’s disease progression. The body could absorb a limited amount of nicotinamide at a time, requiring multiple doses through a day. To overcome such an obstacle which reduces the patient compliance, a sustained/controlled delivery system could be useful.MethodNicotinamide loaded solid lipid nanoparticles (SLN) were prepared and functionalized with polysorbate 80 (S80), phosphatidylserine (PS) or phosphatidic acid (PA). The acquired part… Show more

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Cited by 83 publications
(42 citation statements)
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“…Mouse AD models were, either non-transgenic [ 35 , 36 ], where mice’s brains were injected with a high concentration of Aβ1-42, or transgenic, most frequently used were the APP/PS1 double transgenic mice [ 11 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Rat models of AD, to study NPs effect on memory dysfunction, were all non-transgenic (most often adult Wistar rats), where AD-like brain pathology was elicited by exposing the animals brain to high concentrations of either Aβ1-40 [ 44 ], Aβ1-42 [ 51 , 52 , 53 ], β-amyloid proteins [ 32 ], STZ [ 31 , 56 , 57 ], scopolamine [ 33 ], okadaic acid [ 13 ] or AlCl 3 [ 34 ]. Molecular pathways of amyloid and tau pathology, where NPs’ treatment attenuated memory dysfunction in AD model animals are summarised in Figure 2 .…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Mouse AD models were, either non-transgenic [ 35 , 36 ], where mice’s brains were injected with a high concentration of Aβ1-42, or transgenic, most frequently used were the APP/PS1 double transgenic mice [ 11 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Rat models of AD, to study NPs effect on memory dysfunction, were all non-transgenic (most often adult Wistar rats), where AD-like brain pathology was elicited by exposing the animals brain to high concentrations of either Aβ1-40 [ 44 ], Aβ1-42 [ 51 , 52 , 53 ], β-amyloid proteins [ 32 ], STZ [ 31 , 56 , 57 ], scopolamine [ 33 ], okadaic acid [ 13 ] or AlCl 3 [ 34 ]. Molecular pathways of amyloid and tau pathology, where NPs’ treatment attenuated memory dysfunction in AD model animals are summarised in Figure 2 .…”
Section: Discussionmentioning
confidence: 99%
“…AD rat brain injury models are elicited by (a) a single, intra-cerebro-ventricular injection (i.c.v.i.) of streptozotocin (STZ) [ 31 ] or β amyloid [ 32 ], (b) an intra-peritoneal injection of scopolamine [ 33 ] or (c) a chronic administration of AlCl 3 (aluminium chloride) [ 34 ]. I.c.v.i.…”
Section: Potential Animal Models For Alzheimer′s Disease Memory Immentioning
confidence: 99%
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“…Whilst some patients with Alzheimer’s Disease given nicotinamide adenine dinucleotide (NADH; 10mg daily) did show improvement in mini mental state examination and global deterioration scores [11], others did not [12]. Nicotinamide derivatives such as nicotinamide mononucleotide, nicotinamide riboside [13] and nicotinamide loaded lipid nanoparticles [14] have, at extremely high doses, shown some cognitive benefits in Alzheimer’s disease animal models and in aged mice but their effects on cognition in humans, and at tolerable doses, are unknown [15].…”
Section: Discussionmentioning
confidence: 99%
“…As far as concerned tau protein, the inhibition of its fibrillization is the main target of nicotinamide-loaded solid lipid nanoparticles (SLNs), 62 and protein-capped metal NPs, 63 while a reduction of tau hyperphosphorylation, oxidative stress damage and neuroinflammation were observed testing in vitro and in vivo self-assembly hollow manganese Prussian white nanocapsules, that are nanozymes, ie, nanomaterials with enzyme-like characteristics, 64 and CS sulphate nano-selenium. 65,66 All these NPs succeeded in their goal, however their actions in the control of other clinical hallmarks could not be excluded and should be further evaluated.…”
Section: Nanotechnologies Exploiting New Tools To Force Bbb Openingmentioning
confidence: 99%