Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

Chambon, Pierre; Weill, J; Mandel, P.

doi:10.1016/0006-291x(63)90024-x

Cited by 592 publications

(344 citation statements)

References 8 publications

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“…1G and supplemental Fig. S3), where the vast majority of PARP1 is known to be located (76,77,92,93). Moreover, the need for 10 -40 M veliparib to substantially suppress PAR synthesis is consistent with recent results examining the effects of veliparib on protein poly(ADPribosyl)ation by immunoblotting (64).…”

Section: Discussionsupporting

confidence: 84%

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

Patel

Flatten

Schneider

et al. 2012

Journal of Biological Chemistry

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Background: PARP inhibitors and topoisomerase I poisons (Top1p) synergize by an unknown mechanism. Results: Although Parp1 deletion fails to increase Top1p sensitivity, transfection with catalytically inactive PARP1 or its isolated DNA binding domain does sensitize. Conclusion: PARP inhibitors poison PARP1 to diminish repair of topoisomerase I-triggered DNA damage. Significance: These results predict that tumors with elevated PARP1 will be particularly sensitive to Top1p/PARP inhibitor combinations.

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Section: Discussionsupporting

confidence: 84%

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

Patel

Flatten

Schneider

et al. 2012

Journal of Biological Chemistry

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“…63 PARP is an enzyme that produces large chains of poly(ADP-ribose) from NAD 1 . 104 PARP is involved in the repair of single-strand DNA breaks and its inhibition produces the accumulation of these lesions which may end in the arrest of the replication fork and the formation of DSBs. 105 These DSB are only proficiently repaired by HR.…”

Section: Discussionmentioning

confidence: 99%

The role of BRCA1 and BRCA2 in prostate cancer

Castro¹,

Eeles²

2012

Asian J Androl

135

105

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One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 (BRCA2) are the genetic events known to date that confer the highest risk of prostate cancer (8.6-fold in men f65 years). Although the role of BRCA2 and BRCA1 in prostate tumorigenesis remains unrevealed, deleterious mutations in both genes have been associated with more aggressive disease and poor clinical outcomes. The increasing incidence of prostate cancer worldwide supports the need for new methods to predict outcome and identify patients with potentially lethal forms of the disease. As we present here, BRCA germline mutations, mainly in the BRCA2 gene, are one of those predictive factors. We will also discuss the implications of these mutations in the management of prostate cancer and hypothesize on the potential for the development of strategies for sporadic cases with similar characteristics.

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“…Over 45 years ago Chambon et al [9] demonstrated that addition of NAD+ to hen liver nuclear extracts stimulated synthesis of poly-ADP-ribose. This was followed by the discovery of mono-ADP-ribosylation in studies of bacterial toxins [10].…”

Section: (Adp-ribose) Transferasesmentioning

confidence: 99%

NAD+-Consuming Enzymes in the Regulation of Lung Immune Responses

Legutko¹,

Lekeux²,

Bureau³

2009

TOIJ

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Nicotinamide adenine dinucleotide (NAD+) plays a role as a coenzyme in numerous oxidation-reduction reactions and mediates not only energy metabolism and mitochondrial functions, but also calcium homeostasis, aging, and cell death. Moreover, extensive evidence attests to the great importance of the non-redox functions of NAD+ via NAD+-consuming enzymes. Indeed, ADP-ribose transferases, cADP-ribose synthases and sirtuins emerge as NAD+ dependent enzymes with potent regulatory function in many physiological and pathophysiological processes. They have been shown to be involved in several neurological and cardiovascular disorders as well as in cancer and inflammation. In this review we will summarize the current knowledge about function of NAD+-consuming enzymes in the regulation of the immune system with particular emphasis on lung inflammatory disorders.

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Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

Cited by 592 publications

References 8 publications

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes

The role of BRCA1 and BRCA2 in prostate cancer

NAD+-Consuming Enzymes in the Regulation of Lung Immune Responses

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