Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk

Sazcı, Ali; Sazci, Gensay; Sazci, Bilgen; Ergül, Emel; İdrisoğlu, Halil Atilla

doi:10.1186/s10194-016-0688-8

Cited by 14 publications

(14 citation statements)

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“…50 Vitamin B6, folic acid and vitamin B12 are required for the metabolism of Hcy (remethylation to methionine requires folic acid and vitamin B12, transsulfuration to cystathionine requires pyridoxine). 51,52 Genetic association studies have already demonstrated a genetic link between enzymes involved in the metabolism of Hcy (namely MTHFR 53 and Nicotinamide-N-Methyltransferase variants 54 ) and migraine, but such a genetic association has not been established for cluster headache 55 or other primary headache disorders. 56 In the present study, a systematic search of the literature with regard to the supplementation of Hcy-lowering vitamins for migraine and other primary headache disorders was performed.…”

Section: Discussionmentioning

confidence: 99%

Pyridoxine, folate and cobalamin for migraine: A systematic review

et al. 2020

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Migraine is a common primary headache disorder prevalent among middle-aged adults, with its prevalence peaking in adults during the fourth decade of life and registering its lowest values in adolescents and adults older than 60 years of age. 1 It is often characterized by severe-debilitating headaches that significantly impair everyday functioning and productivity, constituting a major psychological and financial burden for people and society. 2,3 The cardinal pain features of migraine, usually, involve unilateral distribution, throbbing quality, moderate to severe intensity and exacerbation with physical activity. 4,5 Nausea and

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Section: Discussionmentioning

confidence: 99%

Pyridoxine, folate and cobalamin for migraine: A systematic review

et al. 2020

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“…Sazci et al report that previous studies showed an association between methylenetetrahydrofolate reductase (MTHFR) variants C677T (rs1801133), A1298C (rs1801131) and migraine (110). Furthermore, the nicotinamide-N-methyltransferase (NNMT) variant rs694539, expressed in the brain and other nervous tissue as a cytoplasmic enzyme, was associated with migraine presence (110). The implicated MTHFR variants and the NNMT variant have been linked to higher plasma homocysteine levels, which, in turn, have been associated with migraine risk (110).…”

Section: Genetics and Biomarkersmentioning

confidence: 99%

“…Furthermore, the nicotinamide-N-methyltransferase (NNMT) variant rs694539, expressed in the brain and other nervous tissue as a cytoplasmic enzyme, was associated with migraine presence (110). The implicated MTHFR variants and the NNMT variant have been linked to higher plasma homocysteine levels, which, in turn, have been associated with migraine risk (110). However, the association between the NNMT variant and migraine was only found in women, with 4.3 times the odds for women with an AA genotype and the same magnitude of protective effect in individuals with the G allele (110).…”

Section: Genetics and Biomarkersmentioning

confidence: 99%

Giving Researchers a Headache – Sex and Gender Differences in Migraine

et al. 2020

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Migraine is a common neurovascular disorder affecting ∼15% of the general population. Ranking second in the list of years lived with disability (YLD), people living with migraine are greatly impacted by this especially burdensome primary headache disorder. In ∼30% of individuals with migraine, transient neurological symptoms occur (migraine aura) that further increase migraine burden. However, migraine burden is differential with respect to sex. Though one-year prevalences in childhood are similar, starting with puberty, migraine incidence increases at a much higher rate in females than males. Thus, migraine over the life course occurs in women three to four times more often than in men. Attacks are also more severe in women, leading to greater disability and a longer recovery period. The sex disparity in migraine is believed to be partly mediated through fluctuations in ovarian steroid hormones, especially estrogen and progesterone, although the exact mechanisms are not yet completely understood. The release of the neuropeptide calcitonin gene-related peptide (CGRP), followed by activation of the trigeminovascular system, is thought to play a key role in the migraine pathophysiology. Given the burden of migraine and its disproportionate distribution, the underlying cause(s) for the observed differences between sexes in the incidence, frequency, and intensity of migraine attacks must be better understood. Relevant biological as well as behavioral differences must be taken into account. To evaluate the scope of the existing knowledge on the issue of biological sex as well as gender differences in migraine, we conducted a systematized review of the currently available research. The review seeks to harmonize existing knowledge on the topic across the domains of biological/preclinical, clinical, and population-level research, which are traditionally synthesized and interpreted in isolation. Ultimately, we identify knowledge gaps and set priorities for further interdisciplinary and informed research on sex and gender differences as well as gender-specific therapies in migraine.

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“… 19 Sazci et al reported a significant association of the NNMT rs694539 variant with female patients with migraine, but no association with male patients. 47 CoSkun et al suggested that the genotypes rs2229741-GG and rs726281-GG are responsible for reduced risk of migraine in female Turkish patients. 48 Dopamine signaling was demonstrated to be linked to the female hormones, namely, progesterone and prolactin, in the migraineurs.…”

Section: Discussionmentioning

confidence: 99%

Association of expression of <em>DRD2 </em>rs1800497 polymorphism with migraine risk in Han Chinese individuals

Deng¹,

Huang²,

Zhang³

et al. 2018

JPR

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BackgroundPrevious studies suggested that single-nucleotide polymorphisms in dopamine receptor D2 (DRD2) are the susceptibility loci for migraine. This study was aimed at evaluating the contribution of DRD2 rs1800497 and its expression to migraine risk in Han Chinese subjects.MethodsIn total, 250 patients with migraine and 250 age- and sex-matched control subjects were included in this study. TaqMan allelic discrimination assay was used for DRD2 rs1800497 genotyping. Plasma DRD2 concentration was determined using enzyme-linked immunosorbent assay.ResultsSignificant associations were observed for the rs1800497 genotype (c2=6.37, p=0.041) and allele (c2=4.69, p=0.03; odds ratio [OR]=1.33, 95% CI=1.03–1.72, power=58%) frequencies between the migraine and control groups. Sex analysis indicated a positive association for rs1800497 between female patients with migraine and control individuals (genotype: c2=7.84, p=0.019; allele: c2=6.60, p=0.010; OR=1.61, 95% CI=1.12–2.30, power=73.4%). Furthermore, a significant association was observed only in female patients with migraine without aura (MO) (genotype: c2=6.88, p=0.032; allele: c2=5.65, p=0.017; OR=1.59, 95% CI=1.08–2.36, power=65.1%). The mean plasma DRD2 levels in the control group (mean±SD: 24.20±2.78) were significantly lower than those in the migraine with aura (MA) (30.86±3.69, p<0.0001) and MO groups (31.88±4.99, p<0.0001). Additionally, there was a sex-based difference in DRD2 expression in the MA (male vs female: 29.46±3.59 vs 32.27±3.27, p<0.01) and MO groups (male vs female: 29.18±3.50 vs 34.58±4.84, p<0.0001). Moreover, plasma DRD2 levels in patients were significantly different among the three genotypes (CC vs CT vs TT: 24.76±3.76 vs 30.93±3.85 vs 37.06±3.95, p<0.0001). Similar results were observed both in the MA (CC vs CT vs TT: 25.09±3.84 vs 28.57±2.84 vs 33.37±1.58, p<0.0001) and MO groups (CC vs CT vs TT: 24.65±3.79 vs 31.65±3.86 vs 38.29±3.74, p<0.0001).ConclusionOur case–control study suggested that the DRD2 polymorphism rs1800497 was significantly associated with the risk of migraine in Han Chinese females. Additionally, the plasma DRD2 level was high in patients with migraine. Females with migraine had considerably higher DRD2 levels than males with migraine. DRD2 expression may be regulated by DRD2 rs1800497 genotype in patients with migraine.

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Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk

Cited by 14 publications

References 45 publications

Pyridoxine, folate and cobalamin for migraine: A systematic review

Pyridoxine, folate and cobalamin for migraine: A systematic review

Giving Researchers a Headache – Sex and Gender Differences in Migraine

Association of expression of <em>DRD2 </em>rs1800497 polymorphism with migraine risk in Han Chinese individuals

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