Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression

Sun, Siyu; Cao, Yumei; Huo, Yanjie; Qiu, Fei; Quan, Wenjuan; He, Chaoping; Chen, Yu; Liao, Duan‐Fang; Tuo, Qin-Hui

doi:10.1080/19336918.2021.1909899

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Indeed, a study by Li et al (2017) has shown that curcumin attenuates Ang II-induced expressions of inflammatory factors and oxidative stress through induction of PPAR-γ in VSMCs, which is accompanied by suppression of VSMC proliferation. In keeping with this, nicotinate-curcumin, an esterification derivative of niacin and curcumin, markedly prevents Ang IIinduced VSMC phenotype switching, proliferation, and migration via regulating the PTEN/AKT pathway (Sun et al, 2021). As a group of short non-coding RNA, micro RNAs (miRNA) plays a critical role in the process of human diseases, including hypertension (Zhang and Sun, 2020;Zhang and Sun, 2021).…”

Section: Inhibition Of Vascular Smooth Muscle Cell Proliferation and ...mentioning

confidence: 93%

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?

Wang

Machuki

et al. 2022

Front. Physiol.

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Growing evidence suggests that hypertension is one of the leading causes of cardiovascular morbidity and mortality since uncontrolled high blood pressure increases the risk of myocardial infarction, aortic dissection, hemorrhagic stroke, and chronic kidney disease. Impaired vascular homeostasis plays a critical role in the development of hypertension-induced vascular remodeling. Abnormal behaviors of vascular cells are not only a pathological hallmark of hypertensive vascular remodeling, but also an important pathological basis for maintaining reduced vascular compliance in hypertension. Targeting vascular remodeling represents a novel therapeutic approach in hypertension and its cardiovascular complications. Phytochemicals are emerging as candidates with therapeutic effects on numerous pathologies, including hypertension. An increasing number of studies have found that curcumin, a polyphenolic compound derived from dietary spice turmeric, holds a broad spectrum of pharmacological actions, such as antiplatelet, anticancer, anti-inflammatory, antioxidant, and antiangiogenic effects. Curcumin has been shown to prevent or treat vascular remodeling in hypertensive rodents by modulating various signaling pathways. In the present review, we attempt to focus on the current findings and molecular mechanisms of curcumin in the treatment of hypertensive vascular remodeling. In particular, adverse and inconsistent effects of curcumin, as well as some favorable pharmacokinetics or pharmacodynamics profiles in arterial hypertension will be discussed. Moreover, the recent progress in the preparation of nano-curcumins and their therapeutic potential in hypertension will be briefly recapped. The future research directions and challenges of curcumin in hypertension-related vascular remodeling are also proposed. It is foreseeable that curcumin is likely to be a therapeutic agent for hypertension and vascular remodeling going forwards.

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Section: Inhibition Of Vascular Smooth Muscle Cell Proliferation and ...mentioning

confidence: 93%

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?

Wang

Machuki

et al. 2022

Front. Physiol.

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“…Sun et al found that Nicotiniccurcumin(1 μM) and curcumin(10 μM) could inhibit Ang II-induced VSMCs switching from a contractile to a synthetic phenotype by regulating the phosphatase and tensin homolog(PTEN)/Akt pathway. 85 (Figure 4 and Table 1)…”

Section: Protection Of Vsmcs By Curcuminmentioning

confidence: 99%

Review of the Protective Mechanism of Curcumin on Cardiovascular Disease

Yang,

Zhu,

Chen

et al. 2024

DDDT

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Cardiovascular diseases (CVDs) are the most common cause of death worldwide and has been the focus of research in the medical community. Curcumin is a polyphenolic compound extracted from the root of turmeric. Curcumin has been shown to have a variety of pharmacological properties over the past decades. Curcumin can significantly protect cardiomyocyte injury after ischemia and hypoxia, inhibit myocardial hypertrophy and fibrosis, improve ventricular remodeling, reduce drug-induced myocardial injury, improve diabetic cardiomyopathy(DCM), alleviate vascular endothelial dysfunction, inhibit foam cell formation, and reduce vascular smooth muscle cells(VSMCs) proliferation. Clinical studies have shown that curcumin has a protective effect on blood vessels. Toxicological studies have shown that curcumin is safe. But high doses of curcumin also have some side effects, such as liver damage and defects in embryonic heart development. This article reviews the mechanism of curcumin intervention on CVDs in recent years, in order to provide reference for the development of new drugs in the future.

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“…PTEN depletion promotes enhanced Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/ mammalian target of rapamycin (mTOR) signaling under basal conditions and induces VSMC phenotypic modulation (Furgeson et al 2010). Nicotinate-curcumin inhibits AngII-induced VSMC phenotype switching via upregulation of PTEN expression and blocking the activation of phosphorylated AKT (Sun et al 2021). Besides, decreased (Cherepanova et al 2016;Salmon et al 2012;Yu et al 2011).…”

Section: The Transcription Factors Related To the Phenotypic Switchmentioning

confidence: 99%

Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis

Jiang

Hua

2023

Mol Med

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Atherosclerosis (AS), leading to gradual occlusion of the arterial lumen, refers to the accumulation of lipids and inflammatory debris in the arterial wall. Despite therapeutic advances over past decades including intervention or surgery, atherosclerosis is still the most common cause of cardiovascular diseases and the main mechanism of death and disability worldwide. Vascular smooth muscle cells (VSMCs) play an imperative role in the occurrence of atherosclerosis and throughout the whole stages. In the past, there was a lack of comprehensive understanding of VSMCs, but the development of identification technology, including in vivo single-cell sequencing technology and lineage tracing with the CreERT2-loxP system, suggests that VSMCs have remarkable plasticity and reevaluates well-established concepts about the contribution of VSMCs. Transcription factors, a kind of protein molecule that specifically recognizes and binds DNA upstream promoter regions or distal enhancer DNA elements, play a key role in the transcription initiation of the coding genes and are necessary for RNA polymerase to bind gene promoters. In this review, we highlight that, except for environmental factors, VSMC genes are transcriptionally regulated through complex interactions of multiple conserved cis-regulatory elements and transcription factors. In addition, through a series of transcription-related regulatory processes, VSMCs could undergo phenotypic transformation, proliferation, migration, calcification and apoptosis. Finally, enhancing or inhibiting transcription factors can regulate the development of atherosclerotic lesions, and the downstream molecular mechanism of transcriptional regulation has also been widely studied.

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Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression

Cited by 7 publications

References 26 publications

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?

Review of the Protective Mechanism of Curcumin on Cardiovascular Disease

Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis

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