2017
DOI: 10.1542/peds.2016-3436
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Nicotine and Tobacco as Substances of Abuse in Children and Adolescents

Abstract: Nicotine is the primary pharmacologic component of tobacco, and users of tobacco products seek out its effects. The highly addictive nature of nicotine is responsible for its widespread use and difficulty with quitting. This technical report focuses on nicotine and discusses the stages of use in progression to dependence on nicotine-containing products; the physiologic characteristics, neurobiology, metabolism, pharmacogenetics, and health effects of nicotine; and acute nicotine toxicity. Finally, some newer a… Show more

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Cited by 87 publications
(71 citation statements)
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“…Nicotine has harmful neurocognitive effects and addictive properties, particularly in the developing brains of adolescents and young adults. 47 Nicotine exposure during adolescence negatively affects memory, attention, and emotional regulation, 48 as well as executive functioning, reward processing, and learning. 49 The brain undergoes major structural remodeling in adolescence, and nicotine acetylcholine receptors regulate neural maturation.…”
Section: Flavored Vaping Liquids Have Been Associated With Higher Usamentioning
confidence: 99%
“…Nicotine has harmful neurocognitive effects and addictive properties, particularly in the developing brains of adolescents and young adults. 47 Nicotine exposure during adolescence negatively affects memory, attention, and emotional regulation, 48 as well as executive functioning, reward processing, and learning. 49 The brain undergoes major structural remodeling in adolescence, and nicotine acetylcholine receptors regulate neural maturation.…”
Section: Flavored Vaping Liquids Have Been Associated With Higher Usamentioning
confidence: 99%
“…Following repeated exposure to nicotine, the human central nervous system undergoes structural and functional adaptations, such that the brain requires nicotine to function normally, resulting in complex, biosocial maladaptive behaviours, known as dependence [13,14]. Given their developmental stage, adolescents and young adults are uniquely susceptible to social and environmental influences to use tobacco [8,[15][16][17] and nicotine addiction [18,19]. Several lines of evidence indicate that nicotine exposure during adolescence may have lasting adverse consequences for brain development [3,[20][21][22], even in those who smoke infrequently.…”
Section: Introductionmentioning
confidence: 99%
“…34 The earlier in childhood an individual uses nicotinecontaining products, the stronger the addiction and the more difficult it is to quit. 35 The vast majority of adult smokers initiated tobacco use by 18 years of age. 31 E-cigarette solutions are often flavored, with thousands of unique flavors advertised.…”
Section: E-cigarette Solution and Health Effectsmentioning
confidence: 99%