Nicotine Attenuates Relapse to Methamphetamine‐Seeking Behavior (Craving) in Rats

Takato, Hiranita; Anggadiredja, Kusnandar; Fujisaki, Chie; Watanabe, Soichi; Yamamoto, Tsuneyuki

doi:10.1196/annals.1316.062

Cited by 20 publications

(17 citation statements)

References 5 publications

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“…The mechanism for the cross-substitution between nicotine and methamphetamine is evidently some modulation of dopamine levels, directly by methamphetamine, or indirectly by nicotinic acetylcholine receptors in the case of nicotine. Given that both of these compounds modulate self-administration of the other compound (Glick et al, 2002;Hiranita et al, 2004;Hiranita et al, 2006;Rauhut et al, 2003), it is likely that people co-abuse nicotine and methamphetamine because of modulation of their stimulus and reinforcing effects, not just because both compounds are readily available in the same contexts. It is possible that people take the two compounds together because they modify the effects of each other to produce heightened effects or reduce unpleasant side-effects.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic treatment with nicotine for 14 days increased locomotor activity and stereotypy induced by methamphetamine (Suemaru et al, 1993). Nicotine attenuated reinstatement of methamphetamine self-administration (Hiranita et al, 2004;Hiranita et al, 2006), and mecamylamine decreased methamphetamine self-administration in rats (Glick et al, 2002). In rats trained to self-administer nicotine, bupropion and methamphetamine increased selfadministration of low doses of nicotine and decreased self-administration of high doses of nicotine (Rauhut et al, 2003).…”

Section: Interactions Between Methamphetamine and Nicotinementioning

confidence: 95%

“…The most obvious possibility is that nicotinic acetylcholine receptors are located on dopaminergic neurons in the ventral tegmental area which are important in regulating neuronal activity of these dopaminergic neurons (Mameli-Engvall et al, 2006;Ungless and Cragg, 2006). Administration of nicotine modulates dopamine release (Quarta et al, 2006;Wonnacott et al, 2005), and is known to alter behaviors controlled by these dopaminergic pathways including locomotor behavior (Kuribara, 1999;Suemaru et al, 1993) and self-administration of abused compounds, including both nicotine and methamphetamine (Glick et al, 2002;Hiranita et al, 2004;Hiranita et al, 2006;Rauhut et al, 2003). The failure of mecamylamine to block the cross-substitution of methamphetamine in nicotine-trained rats may be related to the finding that perfusion of mecamylamine into the nucleus accumbens did not alter dopamine levels in the ventral tegmental area or the nucleus accumbens (Rahman and McBride, 2002).…”

Section: Mechanismsmentioning

confidence: 99%

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Nicotine and methamphetamine share discriminative stimulus effects

Gatch

Flores

Forster

2008

Drug and Alcohol Dependence

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Background-Nicotine and methamphetamine are both abused in similar settings, sometimes together. Because there are known interactions between central nicotinic acetylcholine receptors and dopamine receptors, it is of interest to characterize the nature of the interaction of these two compounds in vivo.Methods-The purpose of this study was to characterize the extent to which these two compounds produce similar discriminative stimulus effects and to identify pharmacological mechanisms for their interaction. Male Sprague-Dawley rats were trained to discriminate methamphetamine or nicotine from saline. First, the ability of methamphetamine and nicotine to cross-substitute in rats trained to the other compound was tested. Subsequently, the ability of a dopamine antagonist (haloperidol) and a centrally-acting nicotinic antagonist (mecamylamine) to block the discriminative stimulus effects of methamphetamine and nicotine were also tested.Results-Nicotine fully substituted in methamphetamine-trained rats, but methamphetamine only partially substituted in nicotine-trained rats. In nicotine-trained rats, mecamylamine fully antagonized the discriminative stimulus effects of nicotine, but haloperidol had no effect. The partial substitution of methamphetamine was partially attenuated by haloperidol, but not altered by mecamylamine. In methamphetamine-trained rats, mecamylamine failed to antagonize the discriminative stimulus effects of methamphetamine, but haloperidol fully blocked the methamphetamine cue. Mecamylamine blocked the ability of nicotine to substitute for methamphetamine, but haloperidol had no effect.Conclusions-These results indicate that nicotine and methamphetamine share discriminative stimulus effects in some subjects and that the two compounds do not act at the same site, but produce their interaction indirectly. These findings suggest that these two compounds might be at least partially interchangeable in human users, and that there are potentially interesting pharmacological reasons for the commonly observed co-administration of nicotine and methamphetamine.

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Section: Discussionmentioning

confidence: 99%

Section: Interactions Between Methamphetamine and Nicotinementioning

confidence: 95%

Section: Mechanismsmentioning

confidence: 99%

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Nicotine and methamphetamine share discriminative stimulus effects

Gatch

Flores

Forster

2008

Drug and Alcohol Dependence

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“…While there is evidence that nicotine can reinstate alcohol seeking and cocaine seeking in alcohol-preferring P rats , it does not reinstate cocaine seeking in alcohol nonpreferring (NP) rats or other rat strains (Wise et al, 1990;Schenk and Partridge, 1999). Also, nicotine-priming injections do not reinstate food seeking (Shaham et al, 1997) and, surprisingly, attenuate the reinstatement of methamphetamine seeking (Hiranita et al, 2004).…”

Section: Extinction and Reinstatement Of Nicotine Seeking In Adolescementioning

confidence: 99%

Nicotine Self-Administration, Extinction Responding and Reinstatement in Adolescent and Adult Male Rats: Evidence Against a Biological Vulnerability to Nicotine Addiction during Adolescence

Shram

Funk

et al. 2007

Neuropsychopharmacol

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Initiation of smoking behavior typically occurs during adolescence and rarely occurs during adulthood. Despite this epidemiological evidence, relatively little is known about possible neurobiological differences in the response to nicotine in adolescents that might make them more vulnerable to nicotine addiction. In the current study, we assessed nicotine self-administration under fixed ratio (FR) and progressive ratio (PR) reinforcement schedules in adolescent (postnatal day (P) 33-35) and adult (P91-94) rats. We then assessed extinction and reinstatement of nicotine seeking in adulthood in rats that initiated nicotine self-administration during either adolescence or adulthood. Nicotine self-administration (0.03 mg/kg/infusion, i.v.) was higher in adult rats than in adolescent rats under FR5 and PR reinforcement schedules; no age differences in nicotine self-administration were observed under FR1 or FR2 reinforcement schedules. In contrast, saccharin self-administration under FR5 and PR reinforcement schedules was similar in both age groups, potentially ruling out age differences in general performance. Rats that initiated nicotine self-administration as adults demonstrated a greater resistance to extinction of nicotine taking behavior when saline was substituted for nicotine than rats that initiated self-administration as adolescents. Reinstatement of nicotine seeking following nicotine priming injections (0.075, 0.15, 0.3 mg/kg, s.c.) was independent of the age of onset of nicotine self-administration. The present data from established rat models of drug self-administration and drug relapse suggest that nicotine is less reinforcing in adolescent compared with adult rats and that processes other than the reinforcing effects of nicotine may be involved in the greater susceptibility to smoking during the adolescent developmental stage.

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“…The methamphetamine reinstatement studies which have been published have produced results consistent with those generated using other drugs of abuse. For instance, non-contingent priming injections of methamphetamine will reinstate methamphetamine-appropriate responding following extinction (Anggadiredja et al 2004a, Hiranita et al 2004, Kruzich and Xi 2006, Yan et al 2006a. Presentation of cues previously associated with methamphetamine selfadministration results in renewed drug-appropriate responding (Anggadiredja et al 2004b, Moffett and Goeders 2007, Yan et al 2006a.…”

Section: Introductionmentioning

confidence: 99%

Effect of drug-paired exteroceptive stimulus presentations on methamphetamine reinstatement in rats

Shelton

Beardsley

2008

Pharmacology Biochemistry and Behavior

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The purpose of the present study was to examine the impact of drug-paired cues on methamphetamine reinstatement. Three groups of rats were trained to self-administer 0.1 mg/kg/ infusion methamphetamine. Each methamphetamine infusion was accompanied by a 6 s flashing light + tone stimulus (cues). After training, the groups were then given 12, daily extinction sessions either with or without response-contingent drug-paired cues and then tested for 1 mg/kg i.p. methamphetamine priming-induced reinstatement either with or without cues. Methamphetamine priming significantly reinstated drug-appropriate responding regardless of whether response-contingent cues were omitted during both extinction and testing, presented during both extinction and testing, or omitted during extinction but presented during reinstatement testing. The group in which cues were omitted during extinction and presented during reinstatement exhibited significantly greater reinstatement than did the other two groups. A separate group of rats was also tested demonstrating that response-contingent presentation of previously methamphetamine-paired cues alone, without methamphetamine priming, significantly reinstated drug-appropriate responding. These data show that methamphetamine priming produces a robust reinstatement effect which can be influenced by drug-paired cues.

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Nicotine Attenuates Relapse to Methamphetamine‐Seeking Behavior (Craving) in Rats

Cited by 20 publications

References 5 publications

Nicotine and methamphetamine share discriminative stimulus effects

Nicotine and methamphetamine share discriminative stimulus effects

Nicotine Self-Administration, Extinction Responding and Reinstatement in Adolescent and Adult Male Rats: Evidence Against a Biological Vulnerability to Nicotine Addiction during Adolescence

Effect of drug-paired exteroceptive stimulus presentations on methamphetamine reinstatement in rats

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