Nicotine–ethanol interactions in flash-evoked potentials and behavior of Long-Evans rats

Hetzler, Bruce E.; Martin, E

doi:10.1016/j.pbb.2005.12.009

Cited by 11 publications

(13 citation statements)

References 54 publications

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“…Similar findings have been previously reported for ethanol (Hetzler & Bednarek, 2001;Hetzler & Martin, 2006). Baclofen produces a dose-dependent depression of behavior in the rat, with effects beginning to be observed between 5 and 10 mg/kg (Grech & Balster, 1993;Hetzler & Ondracek, 2007).…”

Section: Discussionsupporting

confidence: 90%

“…While early components P 37 and P 47 were increased by ethanol, late component P 87 was significantly reduced in amplitude. This pattern of an increase in an early positive component, combined with a decrease in amplitude of one or more late components has been reported in prior animal studies (Hetzler & Bednarek, 2001;Hetzler & Martin, 2006).…”

Section: Discussionsupporting

confidence: 84%

“…at doses at or slightly below 10 mg/kg typically produce hypothermia (see Hetzler & Ondracek, 2007). Likewise, there have been past reports of ethanol-dependent hypothermia (e.g., Hetzler & Martin, 2006;Rezvani & Levin, 2002).…”

Section: Discussionmentioning

confidence: 96%

“…), diluted in saline. Drug dosages, injection intervals, and testing time following injections were based on prior research (Hetzler & Martin, 2006;Hetzler & Ondracek, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

“…Ethanol produces a pattern of changes in the FEP recorded from the rat visual cortex (VC) (Hetzler & Bednarek, 2001;Hetzler & Martin, 2006). To the extent that activation of GABA B receptors is capable of modulating the effects of ethanol, pretreatment with baclofen would be expected to alter the ethanolinduced changes in FEPs.…”

Section: Introductionmentioning

confidence: 99%

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Baclofen Does Not Counteract the Acute Effects of Ethanol on Flash-Evoked Potentials in Long-Evans Rats

Hetzler

Ondracek

Becker

2008

International Journal of Neuroscience

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This experiment examined the separate and combined effects of baclofen (5.0 mg/kg, i.p.), a GABA B receptor agonist, and ethanol (2.0 g/kg, i.p.) on flash-evoked potentials (FEPs) recorded from both the visual cortex and superior colliculus (SC) of chronically implanted male Long-Evans rats. In the visual cortex, ethanol significantly decreased the amplitude of positive component P87, but increased P37 and P47. Other component amplitudes were not significantly altered. In contrast, baclofen reduced the amplitude of negative component N31 to such an extent that it became positive. Although P47 was also reduced by baclofen, the amplitude of most other components was increased. Only P24 and P87 were unchanged by baclofen. The combination of baclofen and ethanol resulted in amplitudes very similar to ethanol alone for secondary components P47, N62, and P87, but very similar to baclofen alone for primary component N31 and late components N147 and P230. In the SC, component amplitudes were generally decreased by ethanol, baclofen, and the combination treatment. Latencies of most components in both structures were increased by the drug treatments. Each drug treatment produced significant hypothermia. Locomotor behavior was also altered. These results demonstrate: (1) pharmacological differences between the primary and late components versus the secondary components of the cortical FEP, (2) that baclofen does not counteract significant effects of ethanol on cortical or collicular component amplitudes, and (3) that baclofen enhances N147-P230 amplitude, suggesting reduced cortical arousal.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 96%

“…), diluted in saline. Drug dosages, injection intervals, and testing time following injections were based on prior research (Hetzler & Martin, 2006;Hetzler & Ondracek, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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