Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling

Khalifeh, Mohamad; Hobeika, Rouba; Hayek, Lauretta El; Saad, Joelle; Eid, Fadi; El-Khoury, Reine; Ghayad, Litsa-Maria; Jabre, Vanessa; Nasrallah, Patrick; Barmo, Nour; Stephan, Joseph S.; Khnayzer, Rony S.; Khalil, Christian

doi:10.1016/j.bbr.2020.112499

Cited by 13 publications

(3 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rodents exposed to SD, activation of hippocampal BDNF/TRKB signaling (by means of branched-chain amino acids, exercise and high protein diets) induces resilience to social avoidance[ 234 , 235 , 236 ]. In addition, enhancement of BDNF and TRKB levels and signaling has been implicated in the nicotine-induced resilience to the social deficit induced by SD[ 237 ].…”

Section: Advances Concerning the Neurobiological Substrates Of Resiliencementioning

confidence: 99%

Resilience to the effects of social stress on vulnerability to developing drug addiction

Calpe-López¹,

Martínez-Caballero²,

García-Pardo³

et al. 2022

WJP

View full text Add to dashboard Cite

We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse. We define the concept of resilience and how it is applied to the field of drug addiction research. We also describe the internal and external protective factors associated with resilience, such as individual behavioral traits and social support. We then explain the physiological response to stress and how it is modulated by resilience factors. In the subsequent section, we describe the animal models commonly used in the study of resilience to social stress, and we focus on the effects of chronic social defeat (SD), a kind of stress induced by repeated experience of defeat in an agonistic encounter, on different animal behaviors (depression- and anxiety-like behavior, cognitive impairment and addiction-like symptoms). We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depression- and anxiety-related behaviors in rodents. Finally, we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse, describing the current state of knowledge and suggesting future research directions.

show abstract

Section: Advances Concerning the Neurobiological Substrates Of Resiliencementioning

confidence: 99%

Resilience to the effects of social stress on vulnerability to developing drug addiction

Calpe-López¹,

Martínez-Caballero²,

García-Pardo³

et al. 2022

WJP

View full text Add to dashboard Cite

show abstract

“…However, that inference is somewhat undermined by the gamut of research that has used this procedure to study 'anxiety.' 26,27 As with CUMS procedures, a major concern about these studies is that there are appreciable differences in the protocols used in different laboratories, particularly in respect of the time for which the animals are left to interact. In some laboratories, as is the case in the UK, the animals are separated immediately after the first contact but retain sight and smell of each other.…”

Section: Social Defeat Stressmentioning

confidence: 99%

“…24,25 On that basis, this is widely described as a model of ‘depression-like’ behaviour. However, that inference is somewhat undermined by the gamut of research that has used this procedure to study ‘anxiety.’ 26,27…”

Section: Some Procedures That Are Used To Produce Animal ‘Models’ Of mentioning

confidence: 99%

Some Reasons Why Preclinical Studies of Psychiatric Disorders Fail to Translate: What Can Be Rescued from the Misunderstanding and Misuse of Animal ‘Models’?

Stanford

2020

Altern Lab Anim

View full text Add to dashboard Cite

The repeated failure of animal models to yield findings that translate into humans is a serious threat to the credibility of preclinical biomedical research. The use of animals in research that lacks translational validity is unacceptable in any ethical environment, and so this problem needs urgent attention. To reproduce any human illness in animals is a serious challenge, but this is especially the case for psychiatric disorders. Yet, many authors do not hesitate to describe their findings as a ‘model’ of such a disorder. More cautious scientists describe the behavioural phenotype as ‘disorder-like’, without specifying the way(s) in which the abnormal behaviour could be regarded as being analogous to any of the diagnostic features of the disorder in question. By way of discussing these problems, this article focuses on common, but flawed, assumptions that pervade preclinical research of depression and antidepressants. Particular attention is given to the difference between putative ‘models’ of this illness and predictive screens for candidate drug treatments, which is evidently widely misunderstood. However, the problems highlighted in this article are generic and afflict research of all psychiatric disorders. This dire situation will be resolved only when funders and journal editors take action to ensure that researchers interpret their findings in a less ambitious, but more realistic, evidence-based way that would parallel changes in research of the cause(s), diagnosis and treatment of psychiatric problems in humans.

show abstract

E-cigarette aerosol induced cytotoxicity, DNA damages and late apoptosis in dynamically exposed A549 cells

et al. 2021

View full text Add to dashboard Cite

Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling

Cited by 13 publications

References 66 publications

Resilience to the effects of social stress on vulnerability to developing drug addiction

Resilience to the effects of social stress on vulnerability to developing drug addiction

Some Reasons Why Preclinical Studies of Psychiatric Disorders Fail to Translate: What Can Be Rescued from the Misunderstanding and Misuse of Animal ‘Models’?

E-cigarette aerosol induced cytotoxicity, DNA damages and late apoptosis in dynamically exposed A549 cells

Contact Info

Product

Resources

About