Nicotine Patch for the Prevention of Postoperative Nausea and Vomiting

Ionescu, Daniela; Bădescu, C; Acalovschi, I

doi:10.2165/00044011-200727080-00004

Cited by 22 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difference in the incidence of vomiting by patients given placebo and those receiving ondansetron at 12 h was quite high (30 vs. 10%, p = 0.013, odds ratio 4, 95% confidence interval 1.17-8.5), but it did not reach statistical significance with the Bonferroni correction ( Table 2). On the other hand, the ondansetron group included significantly more smokers than the placebo group (Table 1) which might have affected our results since smoking has a prophylactic effect against PONV [19,20].…”

Section: Discussionmentioning

confidence: 96%

Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents

et al. 2011

View full text Add to dashboard Cite

show abstract

“…This effect is independent of other characteristics such as primary cancer site, treatment arm, and education. Investigations on postoperative nausea and vomiting have shown a similar finding, in which smokers experienced less incidence of the symptoms than nonsmokers . This result was not expected because tobacco and nicotine use have shown an emetogenic effect .…”

Section: Discussionmentioning

confidence: 67%

Risk factors for clinician‐reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129

Xiao

Hanlon

Zhang

et al. 2013

Cancer

View full text Add to dashboard Cite

BACKGROUND Chemoradiotherapy has become the standard of care for head and neck squamous cell carcinoma; however, those patients often experience multiple treatment-related symptoms or symptom clusters. Two symptom clusters have been identified for this population. Little is known about the risk factors of these symptom clusters. METHODS Subjects comprised 684 patients who were treated with concurrent chemoradiotherapy in a phase III randomized clinical trial. This trial compared standard fractionation radiotherapy to accelerated fractionation radiotherapy. Symptom clusters were evaluated at the end of the first and the second cycle of chemotherapy, and 3 months after the start of radiotherapy. Mixed-effect modeling was used to observe risk factors for symptom clusters. RESULTS Race and education were independent predictors for the head and neck cluster, while gender and history of tobacco use were for the gastrointestinal cluster. Primary cancer site was only significant for the head and neck cluster when other factors were not controlled: oropharyngeal cancer patients had more severe symptoms in the head and neck clusters than laryngeal cancer patients. Additionally, patients receiving accelerated fractionation radiotherapy experienced more symptoms of radiomucositis, pain, and nausea at 3 months after the start of radiotherapy than those receiving standard fractionation radiotherapy. CONCLUSION Demographic characteristics were more predictive to symptom clusters, while clinical characteristics, such as cancer site and treatment arms, were more significant for individual symptoms. Knowing the risk factors will enhance the capability of clinicians to evaluate patients’ risk of severe symptom clusters and to personalize management strategies.

show abstract

“…The association between preoperative nausea and vomiting and decreased risk of PONV identified herein is simulated by evidence indicating that cigarette smoking and preoperative nicotine patches, which are potent emetogens [10], are also associated with PONV suppression [4,11]. Sweeney [12] has suggested that the suppressive effect of smoking on PONV risk could plausibly be explained by sustained preoperative stimulation of the vomiting centers resulting in adaptation, but subsequently rejected this postulate on the basis that the emetogenic effect of smoking disappears rapidly in persistent smokers.…”

Section: Discussionmentioning

confidence: 96%

Emergency open cholecystectomy is associated with markedly lower incidence of postoperative nausea and vomiting (PONV) than elective open cholecystectomy: a retrospective cohort study

East

Mitchell

2010

BMC Surg

View full text Add to dashboard Cite

BackgroundDuring a previous study to define and compare incidence risks of postoperative nausea and vomiting (PONV) for elective laparoscopic and open cholecystectomy at two hospitals in Jamaica, secondary analysis comparing PONV risk in elective open cholecystectomy to that after emergency open cholecystectomy suggested that it was markedly reduced in the latter group. The decision was made to collect data on an adequate sample of emergency open cholecystectomy cases and further explore this unexpected finding in a separate study.MethodsData were collected for 91 emergency open cholecystomy cases identified at the two paricipating hospitals from May 2007 retrograde, as was done for the 175 elective open cholecystectomy cases (from the aforementioned study) with which the emergency cases were to be compared. Variables selected for extraction and statistical analysis included all those known, suspected and plausibly associated with the risk of PONV and with urgency of surgery.ResultsEmergency open cholecystectomy was associated with a markedly reduced incidence risk of PONV compared to elective open cholecystectomy (6.6% versus 28.6%, P < 0.001). The suppressive effect of emergency increased after adjustment for confounders in a multivariable logistic regression model (odds ratio 0.103, P < 0.001). This finding also identifies, by extrapolation, an association between reduced risk of PONV and preoperative nausea and vomiting, which occurred in 80.2% of emergency cases in the 72 hour period preceding surgery.ConclusionsThe incidence risk of postoperative nausea and vomiting is markedly decreased after emergency open cholecystectomy compared to elective open cholecystectomy. The study, by extrapolation, also identifies a paradoxical association between pre-operative nausea and vomiting, observed in 80.2% of emergency cases, and suppression of PONV. This association, if confirmed in prospective cohort studies, may have implications for PONV prophylaxis if it can be exploited at a sub-clinical level.

show abstract

Nicotine Patch for the Prevention of Postoperative Nausea and Vomiting

Abstract: Nicotine significantly reduced the incidence of PONV after laparoscopic cholecystectomy.

Cited by 22 publications

References 19 publications

Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents

Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents

Risk factors for clinician‐reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129

Emergency open cholecystectomy is associated with markedly lower incidence of postoperative nausea and vomiting (PONV) than elective open cholecystectomy: a retrospective cohort study

Contact Info

Product

Resources

About