Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice

Singh, Prableen K.; Lutfy, Kabirullah

doi:10.1016/j.pbb.2017.07.010

Cited by 6 publications

(5 citation statements)

References 63 publications

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“…There is emerging evidence that, unlike the effects seen on discrete stimuli, nicotine pretreatment may impair the strength of drug-associated contextual memories. Acute systemic and intracranial nicotine pretreatment limits the acquisition of conditioned place preference (CPP) to lower doses of morphine and cocaine 11,29,30 and conditioned place avoidance from naloxone-precipitated morphine withdrawal 31,32 . Additionally, across multiple commonly abused substances, acute systemic nicotine pretreatment impairs the formation of conditioned taste avoidance (CTA) following contextual presentation of a taste stimulus that predicts passive administration of the drug stimulus 12,22,23 .…”

mentioning

confidence: 99%

Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex

Loney

King

Meyer

2021

Sci Rep

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Habitual use of nicotine containing products increases propensity to misuse prescription opioids and its prevalence is substantially increased in individuals currently involved in opioid-treatment programs. Nicotine enhances self-administration of many classes of drugs in rodents, though evidence for direct effects on opioids is lacking. We sought to measure the effects of nicotine pretreatment on the reinforcing efficacy of opioids in both self-administration and contextual conditioning paradigms. First, we measured the effect of systemic nicotine pretreatment on self-administration of two opioids. Additionally, we measured the degree to which systemic nicotine pretreatment impacts the formation of morphine-associated contextual memories in conditioned taste avoidance and place preference paradigms. Given the involvement of the insula in the maintenance of substance abuse, its importance in nicotine addiction, and findings that insular inactivation impairs contextual drug conditioning, we examined whether nicotine administered directly to the insula could recapitulate the effects of systemic nicotine. We demonstrate that systemic nicotine pretreatment significantly enhances opioid self-administration and alters contextual conditioning. Furthermore, intra-insula nicotine similarly altered morphine contextual conditioning by blocking the formation of taste avoidance at all three morphine doses tested (5.0, 10, and 20 mg/kg), while shifting the dose–response curve of morphine in the place preference paradigm rightward. In conclusion, these data demonstrate that nicotine facilitates opioid intake and is partly acting within the insular cortex to obfuscate aversive opiate memories while potentiating approach to morphine-associated stimuli at higher doses.

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mentioning

confidence: 99%

Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex

Loney

King

Meyer

2021

Sci Rep

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“…The pretreatment of nicotine or cocaine before the other has shown to have varying effects [188]. Preclinical studies have shown that animals pretreated with nicotine in early adolescence demonstrate increased rewarding effects of cocaine as well as locomotor sensitization [189][190][191][192]. In another study, pretreatment with nicotine reduced the rewarding effect of cocaine in adult mice [193].…”

Section: Cocainementioning

confidence: 99%

“…Preclinical studies have shown that animals pretreated with nicotine in early adolescence demonstrate increased rewarding effects of cocaine as well as locomotor sensitization [ 189 – 192 ]. In another study, pretreatment with nicotine reduced the rewarding effect of cocaine in adult mice [ 193 ]. Thus, while there is research demonstrating a positive synergistic process between these substances’ dual use, more research is required to better observe the health effects on humans.…”

Section: Cocainementioning

confidence: 99%

“…Preclinical studies on rats showed the prior nicotine exposure increase cocaine self-administration but this was only observed in adolescent but not adult rats [ 204 ]. However, pretreatment with nicotine in adult mice showed decreased cocaine-induced condition place preference, and the robustness of the response was dependent on nicotine dosage [ 193 ]. Clinical research regarding the link between conventional cigarette and cocaine use has similarly produced mixed results.…”

Section: Cocainementioning

confidence: 99%

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E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs

Chen

Rahman²,

Lutfy³

2023

Adv. Drug Alcohol Res.

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Electronic cigarettes (e-cigarettes) are devices that allow the user to inhale nicotine in a vapor, and are primarily marketed as a means of quitting smoking and a less harmful replacement for traditional cigarette smoking. However, further research is needed to determine if vaping nicotine via e-cigarettes can be effective. Conversely, nicotine has been considered a gateway drug to alcohol and other addictive drugs and e-cigarettes containing nicotine may have the same effects. Previous reports have shown that e-cigarette use may open the gate for the use of other drugs including conventional cigarettes, cannabis, opioids, etc. The increasing prevalence of e-cigarettes, particularly among youth and adolescents in the last decade have led to an increase in the dual use of e-cigarettes with alcohol, cannabis, and other illicit drug use like heroin and 3-4-methylenedioxymethamphetamine (MDMA). The advent of e-cigarettes as a device to self-administer addictive agents such as cocaine and synthetic cathinones may bring about additional adverse health effects associated with their concurrent use. This review aims to briefly describe e-cigarettes and their different generations, and their co-use with other addictive drugs as well as the use of the device as a tool to self-administer addictive drugs, such as cocaine, etc.

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“…There is emerging evidence that, unlike the effects seen on discrete stimuli, nicotine pretreatment may impair the strength of drugassociated contextual memories. Acute systemic and intracranial nicotine pretreatment limits the acquisition of conditioned place preference (CPP) to lower doses of morphine and cocaine 11,29,30 and conditioned place avoidance from naloxone-precipitated morphine withdrawal 31,32 . Additionally, across multiple commonly abused substances, acute systemic nicotine pretreatment impairs the formation of conditioned taste avoidance (CTA) following contextual presentation of a taste stimulus that predicts passive administration of the drug stimulus 12,22,23 .…”

Section: Introductionmentioning

confidence: 99%

Nicotine and Opioid Polysubstance Abuse: Enhancement of opioid self-administration by systemic nicotine and modulation of opioid-associated memories by insular nicotine

Loney¹,

King²,

Meyer³

2020

Preprint

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Concurrent nicotine use is associated with increased liability for the development and exacerbation of opioid-use disorders. Habitual use of nicotine containing products increases propensity to misuse prescription opioids and its prevalence is substantially increased in individuals currently involved in opioid-treatment programs. Nicotine enhances self-administration of many classes of drugs in rodents, though evidence for direct effects on opioids is lacking. We sought to measure the effects of nicotine pretreatment on the reinforcing efficacy of opioids in both self-administration and contextual conditioning paradigms. First, we measured the effect of systemic nicotine pretreatment on self-administration of two opioids. Additionally, we measured the degree to which systemic nicotine pretreatment impacts the formation of morphine-associated contextual memories in conditioned taste avoidance and place preference paradigms. Given the involvement of the insula in the maintenance of substance abuse, its importance in nicotine addiction, and findings that insular inactivation impairs contextual drug conditioning, we examined whether nicotine administered directly to the insula could recapitulate the effects of systemic nicotine. We demonstrate that systemic nicotine pretreatment significantly enhances opioid self-administration and alters contextual conditioning. Furthermore, intra-insula nicotine similarly altered morphine contextual conditioning by blocking the formation of taste avoidance at all three morphine doses tested (5.0, 10, & 20 mg/kg), while shifting the dose-response curve of morphine in the place preference paradigm rightward. In conclusion, these data demonstrate that nicotine facilitates opioid intake and is partly acting within the insular cortex to obfuscate aversive opiate memories while potentiating approach to morphine-associated stimuli at higher doses.

show abstract

Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice

Cited by 6 publications

References 63 publications

Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex

Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex

E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs

Nicotine and Opioid Polysubstance Abuse: Enhancement of opioid self-administration by systemic nicotine and modulation of opioid-associated memories by insular nicotine

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