Nicotine suppresses bone sialoprotein gene expression

Abstract

This study indicates that nicotine suppresses BSP transcription mediated through CRE, FRE and HOX elements in the proximal promoter of the rat BSP gene.

Smoking Modulates Gene Expression of Type I Collagen, Bone Sialoprotein, and Osteocalcin in Human Alveolar Bone

“…Interestingly, in the present study, BSP and OCN genes, direct players in the mineralization process, showed lower expression in smokers. A decrease in OCN production also was observed in a previous cell culture study 39 and corroborates the present results. Moreover, it could highlight the major impact of smoking habits on mineralization and not on matrix production.…”

“…Moreover, it could highlight the major impact of smoking habits on mineralization and not on matrix production. Nakayama et al, 39 in a study of rat osteoblast-like cell culture, identified a suppressive effect of nicotine on BSP production, which also corroborates the present findings and those of others. 40 However, interestingly, the suppressive effect of nicotine on proliferation was biphasic, with a decrease at 2 hours, recovering to near control levels at 6 hours, and maximally decreasing at 48 hours.…”

Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease

“…(41,42) Nicotine, a major ingredient in tobacco, has been reported to induce both stimulation and inhibition of proliferation and differentiation of osteoblasts. (43) Rothern and colleagues (44) demonstrated in a cultured human osteoblast-like cell line that nicotine, in low concentrations, increases cell proliferation and expression of genes that mediate bone formation. High concentrations of nicotine were shown to suppress osteoblast activity.…”

Osteoblast physiology in normal and pathological conditions

“…Indeed, nicotine acts directly on osteoblasts inhibiting their proliferation and differentiation (Nakayama et al 2009). Recently, however, a possible positive effect of nicotine has been demonstrated, for the first time, on bone metabolism; at a low concentration, corresponding to those acquired by a moderate smoker, nicotine appears to be able to increase osteoblast proliferation and to improve bone metabolism (Rothem et al 2009).…”