Nicotine Withdrawal Increases Threat-Induced Anxiety but Not Fear: Neuroadaptation in Human Addiction

Hogle, Joanne M.; Kaye, Jesse T.; Curtin, John J.

doi:10.1016/j.biopsych.2010.06.003

Cited by 72 publications

(129 citation statements)

References 48 publications

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“…Animal neuroscience addiction models suggest that neuroadaptation in the response to uncertain threats and other stressors following repeated, chronic drug use provides one important mechanism in the etiology of alcohol and other drug addiction 8 . Research from our laboratory using these cued threat tasks has provided preliminary support for this etiological mechanism in humans 29,34,44 .…”

Section: Discussionmentioning

confidence: 88%

“…The NPU task manipulates uncertainty regarding both IF (shock probability) and WHEN (shock timing) shocks will occur. The NPU task has been used to examine drug administration and deprivation effects on negative affective response 4,34 and etiological mechanisms in mood and anxiety disorders [22][23][24][41][42][43] . In other research, Curtin and colleagues have also developed variants of these cued threat tasks that precisely manipulate threat uncertainty about WHEN (shock timing) 5,29,44 ; WHERE (administration location on body for shock) 25 ; and HOW BAD (shock intensity) 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Affix two shock electrodes with standard medical tape to the participant's hand (e.g., distal phalanges of index and ring fingers of the hand) [33][34][35] . 2.…”

Section: Shock Tolerance Threshold Assessmentmentioning

confidence: 99%

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Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Bradford

Magruder

Korhumel

et al. 2014

JoVE

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Fear of certain threat and anxiety about uncertain threat are distinct emotions with unique behavioral, cognitive-attentional, and neuroanatomical components. Both anxiety and fear can be studied in the laboratory by measuring the potentiation of the startle reflex. The startle reflex is a defensive reflex that is potentiated when an organism is threatened and the need for defense is high. The startle reflex is assessed via electromyography (EMG) in the orbicularis oculi muscle elicited by brief, intense, bursts of acoustic white noise (i.e., "startle probes"). Startle potentiation is calculated as the increase in startle response magnitude during presentation of sets of visual threat cues that signal delivery of mild electric shock relative to sets of matched cues that signal the absence of shock (no-threat cues). In the Threat Probability Task, fear is measured via startle potentiation to high probability (100% cue-contingent shock; certain) threat cues whereas anxiety is measured via startle potentiation to low probability (20% cue-contingent shock; uncertain) threat cues. Measurement of startle potentiation during the Threat Probability Task provides an objective and easily implemented alternative to assessment of negative affect via self-report or other methods (e.g., neuroimaging) that may be inappropriate or impractical for some researchers. Startle potentiation has been studied rigorously in both animals (e.g., rodents, non-human primates) and humans which facilitates animal-to-human translational research. Startle potentiation during certain and uncertain threat provides an objective measure of negative affective and distinct emotional states (fear, anxiety) to use in research on psychopathology, substance use/abuse and broadly in affective science. As such, it has been used extensively by clinical scientists interested in psychopathology etiology and by affective scientists interested in individual differences in emotion. Video LinkThe video component of this article can be found at

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Bradford

Magruder

Korhumel

et al. 2014

JoVE

Self Cite

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“…Nicotine withdrawal induces an increased anxiety state in both human [37][38][39][40][41] and animal models. [42][43][44][45][46] By utilizing three behavioral paradigms known to assess anxiety-like behavior, we found that BDNF Met/Met mice have reduced anxiety-like behavior following nicotine withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice

Lee

Anastasía

Hempstead

et al. 2015

NICTOB

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“…Although craving and cognitive impairments are reliable markers of nicotine withdrawal (Kenney and Gould, 2008;Levin et al, 2006;McClernon et al, 2004;Rezvani and Levin, 2001), anxiety has been shown to impact relapse rate as well (Dani and Harris, 2005;DiMatteo et al, 2000). Furthermore, nicotine withdrawal itself induces an increased anxiety state in both human (Dani et al, 2005;Hogle et al, 2010;Picciotto et al, 2002;Piper et al, 2011;Pomerleau et al, 2005) and animal models (Costall et al, 1989;Irvine et al, 2001;Jackson et al, 2008Jackson et al, , 2009Jonkman et al, 2005;Stoker et al, 2008). A recent functional imaging study in smokers correlated affect with aberrant activation in the hippocampus during smoking cue presentation (McClernon et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal

Turner

Wilkinson

Poole

et al. 2013

Neuropsychopharmacol

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Smoking is the largest preventable cause of death in the United States. Furthermore, a recent study found that o10% of quit attempts resulted in continuous abstinence for 1 year. With the introduction of pharmacotherapies like Chantix (varenicline), a selective a4b2 nicotinic partial agonist, successful quit attempts have significantly increased. Therefore, novel subtype-specific nicotinic drugs, such as sazetidine-A, present a rich area for investigation of therapeutic potential in smoking cessation. The present studies examine the anxietyrelated behavioral and functional effects of the nicotinic partial agonists varenicline and sazetidine-A during withdrawal from chronic nicotine in mice. Our studies indicate that ventral hippocampal-specific infusions of sazetidine-A, but not varenicline, are efficacious in reducing nicotine withdrawal-related anxiety-like phenotypes in the novelty-induced hypophagia (NIH) paradigm. To further investigate functional differences between these partial agonists, we utilized voltage-sensitive dye imaging (VSDi) in ventral hippocampal slices to determine the effects of sazetidine-A and varenicline in animals chronically treated with saline, nicotine, or undergoing 24 h withdrawal. These studies demonstrate a functional dissociation of varenicline and sazetidine-A on hippocampal network activity, which is directly related to previous drug exposure. Furthermore, the effects of the nicotinic partial agonists in VSDi assays are significantly correlated with their behavioral effects in the NIH test. These findings highlight the importance of drug history in understanding the mechanisms through which nicotinic compounds may be aiding smoking cessation in individuals experiencing withdrawal-associated anxiety.

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Nicotine Withdrawal Increases Threat-Induced Anxiety but Not Fear: Neuroadaptation in Human Addiction

Cited by 72 publications

References 48 publications

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice

Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal

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