Nicotinic Acid in the Treatment of Schizophrenias: Canadian Mental Health Association Collaborative Study Progress Report II

Ban, Thomas A.; Lehmann, H. E.

doi:10.1177/070674377502000203

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…In psychiatry, uncontrolled studies or ones with inappropriate control groups have resulted in brief flurries of interest in such treatments as hemodialysis, megavitamins, or beta-endorphins for schizophrenia. In each case, later studies using proper controls yielded negative findings (e.g., Ban & Lehmann, 1975;Janowsky, Judd, Huey, Risch, & Segal, 1983). Sinclair (1966) quantified this effect in the field of the treatment of respiratory distress syndrome.…”

Section: Random Assignment To Treatmentmentioning

confidence: 96%

Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective

Streiner

Adam

1987

Suicide & Life Threat Behav

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Many studies that attempt to evaluate the effectiveness of treatment programs for suicidal patients are methodologically deficient in one or more areas. This paper outlines six criteria that should be met in designing such investigations: Patients should be randomly assigned to groups; at least 80% of the subjects who were initially enrolled should be followed up; the results should be both statistically significant and clinically important; all clinically relevant outcomes should be reported; the patients must be adequately described; and the new intervention should be feasible in other settings. It is shown that these criteria are both necessary and achievable.

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Section: Random Assignment To Treatmentmentioning

confidence: 96%

Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective

Streiner

Adam

1987

Suicide & Life Threat Behav

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“… Hoffer (1971 , 1972) published two more positive results with B vitamins. However, attempts to replicate his findings seem to have failed ( Ban and Lehmann, 1975 ; Wittkopp and Abuzzahab, 1972 ). The contradicting findings may be explained because vitamine B is suggested to be effective in early psychosis but not in chronic schizophrenia ( Hoffer and Osmond, 1964 ).…”

Section: Reviewmentioning

confidence: 99%

Natural Medicines for Psychotic Disorders

Hoenders¹,

Bartels-Velthuis²,

Vollbehr³

et al. 2018

J Nerv Ment Dis

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Patients with psychotic disorders regularly use natural medicines, although it is unclear whether these are effective and safe. The aim of this study was to provide an overview of evidence for improved outcomes by natural medicines. A systematic literature search was performed through Medline, PsycINFO, CINAHL, and Cochrane until May 2015. In 110 randomized controlled trials, evidence was found for glycine, sarcosine, N-acetylcysteine, some Chinese and ayurvedic herbs, ginkgo biloba, estradiol, and vitamin B6 to improve psychotic symptoms when added to antipsychotics. Ginkgo biloba and vitamin B6 seemed to reduce tardive dyskinesia and akathisia. Results on other compounds were negative or inconclusive. All natural agents, except reserpine, were well tolerated. Most study samples were small, study periods were generally short, and most results need replication. However, there is some evidence for beneficial effects of certain natural medicines.

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“…20 Crucially, no laboratory other than Hoffer's ever detected adrenochrome in blood samples. Worst of all, the CMHA, which had supported Hoffer hitherto, funded a series of studies which conclusively demonstrated that nicotinic acid therapy was ineffective (Ban, 1971a(Ban, , 1971bBan and Lehrmann, 1971). Because Hoffer refused to retract his assertions, organizers of international meetings ceased to invite him or his researchers to present papers.…”

Section: Psychiatric Research In Saskatchewanmentioning

confidence: 99%

“…In 1961 Theodore L. Sourkes, a biochemist at the Department of Psychiatry, McGill University, wrote a review article on the biochemistry of mental illness in which he cited several articles presenting evidence fatal to the adrenochrome theory (Sourkes, 1961). Worst of all, the CMHA, which had supported Hoffer hitherto, funded a series of studies which conclusively demonstrated that nicotinic acid therapy was ineffective (Ban, 1971a(Ban, , 1971bBan and Lehrmann, 1971).…”

Section: Psychiatric Research In Saskatchewanmentioning

confidence: 99%

Lessons from the periphery: psychiatry in Saskatchewan, Canada, 1944—68

Mills

2007

Hist Psychiatry

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The government of the Saskatchewan Co-Operative Commonwealth Federation, when elected in 1944, established programmes for the state-funded care of all those suffering from mental illness. It enacted legislation covering the care and treatment of the mentally ill and created a division of the Department of Public Health, the Psychiatric Services Branch (PSB), which both recruited and trained psychiatric staff, meeting the need for nonmedical staff by creating a programme for the training of psychiatric nurses in Saskatchewan. The PSB devised the Saskatchewan Plan for the delivery of rural services, centred on small mental hospitals of a revolutionary design. Even though never fully instantiated, the Plan commanded worldwide attention. Saskatchewan was also remarkable for its research programmes, covering almost all aspects of psychiatry.

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Nicotinic Acid in the Treatment of Schizophrenias: Canadian Mental Health Association Collaborative Study Progress Report II

Cited by 11 publications

References 13 publications

Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective

Evaluation of the Effectiveness of Suicide Prevention Programs: A Methodological Perspective

Natural Medicines for Psychotic Disorders

Lessons from the periphery: psychiatry in Saskatchewan, Canada, 1944—68

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