Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats

Zhang, Sen; Li, Hongyan; Li, Yan; Zhang, Furong; Liu, Yue; Chen, Xiaoguang

doi:10.3892/br.2012.26

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Hypertension is an important risk factor in the pathogenesis of hypertensive renal injury, which is one of the leading causes of chronic kidney disease worldwide (1)(2)(3)(4). Analysis of epidemiological data from dialysis registries in Japan and the USA (5-7) has shown that the incidence of end-stage renal disease due to hypertensive nephrosclerosis is increasing in a number of countries.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats

Jun

Zhang

Yang

2014

Molecular Medicine Reports

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Previous studies have demonstrated that a natural product of celery seeds, 3‑n‑butylphthalide (NBP), has significant antihypertensive effects that are widely utilized in Chinese traditional medicine. The present study aimed to investigate the effects of NBP on hypertensive nephropathy, as well as the mechanisms underlying this disease in spontaneously hypertensive rats (SHRs). SHRs were treated orally with saline, NBP (15 or 30 mg/kg) or losartan (10 mg/kg) daily for 20 weeks, during which time blood pressure was measured every four weeks. At the end of the 20‑week treatment, blood and urine samples were collected for biochemical analysis, and kidney tissues were obtained for histopathological analysis and immunohistochemistry. Enzyme‑linked immunosorbent assays and western blotting were used to analyze the expression of transforming growth factor (TGF)‑β1 in blood and kidney tissues, respectively. The results showed that NBP effectively attenuated progression of hypertensive nephropathy by decreasing urinary albumin excretion and blood urea nitrogen levels. It significantly decreased blood pressure (although less markedly than losartan) and the incidence of glomerulosclerosis. In addition, it alleviated tubular impairment and significantly decreased oxidative stress, as well as the expression of pro‑inflammatory cytokines and TGF-‑β1 in kidney tissues. In conclusion, the results suggested that NBP may slow the progression of hypertensive nephropathy by a variety of mechanisms.

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Section: Introductionmentioning

confidence: 99%

Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats

Jun

Zhang

Yang

2014

Molecular Medicine Reports

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“…Также есть наблюдения о существенной роли окислительного стресса в развитии УРГ [6,7]. В ряде исследований наблюдали при УРГ существенное снижение оксида азота и продуктов его распада [8][9][10]. Поддержанию УРГ в хронической стадии способствует ремоделирование сердца и сосудов, вызванное гемодинамической нагрузкой и действием ангиотензина II и эндотелина-1 [3, 5,8].…”

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Meta-Analysis of Dependence of the Development of Experimental Renovascular Hypertension “2 Kidneys, 1 Clamp” on Lifestyle Factors

Kuzmenko,

Tsyrlin,

Pliss

2023

Transl. med. (Print)

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Background. According to WHO controllable hypertension risk factors include an unhealthy diet, physical inactivity, and wrong daily routine. To date, a large number of experimental studies in rats have studied the effect on the development of unilateral renovascular hypertension (URH) of dietary supplements (minerals, vitamins, flavonoids, caffeine, fats, carbohydrates), physical activity and melatonin therapy.Objective. To conduct a meta- analysis of studies on risk factors for the development of URH.Design and methods. The search for publications was carried out in the PubMed, Scopus, Google Scholar databases. A total of 52 publications were selected.Results. The severity of hypertension decreases when the diet is enriched with potassium, as well as with various antioxidants (vitamin C, flavonoids, melatonin), which reduce oxidative stress in the ischemic kidney. In addition, physical activity can help reduce blood pressure in URH, but at the same time, it increases myocardial hypertrophy. There was no hypertensive effect of increased sodium chloride intake in renal artery stenosis, and no effect of calcium or magnesium supplementation on the URH development. At the same time, caffeine intake significantly increases plasma renin activity and blood pressure in URH.Conclusion. The majority of experimental studies included in our meta-analysis investigated the influence of factors on the development of URH, but not their effect on blood pressure in the chronic stage of URH.

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Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia

Sharma

Gaur²,

Jayant³

et al. 2022

Pharmacol. Rep

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Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats

Cited by 5 publications

References 12 publications

Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats

Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats

Meta-Analysis of Dependence of the Development of Experimental Renovascular Hypertension “2 Kidneys, 1 Clamp” on Lifestyle Factors

Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia

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