Nifedipine controlled delivery by sandwiched osmotic tablet system

Liu, Longxiao; Ku, Jeong; Khang, Gilson; Lee, Bong; Rhee, John M.; Lee, Hai Bang

doi:10.1016/s0168-3659(00)00243-1

Cited by 101 publications

(45 citation statements)

References 9 publications

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“…The rate of water ingress was partially dependent on the permeability of the coating: the thicker coating, the lower water permeability. As the thickness increased, the resistance of the membrane to water diffusion increased and the rate of imbibing water decreased (or to say the lag time become longer), and in turn, the liquification rate of the tablet core decreased, resulting in the drug release rate decreasing (Liu et al, 2000;Ofori-Kwakye & Fell, 2003).…”

Section: Influences Of Membrane Thicknessmentioning

confidence: 99%

The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive

Xie

Yang²,

Yang³

et al. 2014

Drug Delivery

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(2016) The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive, Drug Delivery, 23:7, 2193-2204, DOI: 10.3109/10717544.2014 AbstractA novel, self-administration drug delivery system for subcutaneous infusion was developed and evaluated. The device includes two main components: an osmotic tablet controlled gas actuator and a syringe catheter system. The sodium carbonate in the osmotic pump tablet will release into the surround citric acid solution and produce CO 2 gas, which will drive the drug solution into subcutaneous tissue. The key formulation factors of the osmotic tablet that would influence the infusion profiles of the device were investigated by single factor exploration. The formulation was optimized via a response surface methodology. With an 18 ± 4 min of lag time, the delivery system was able to infuse at an approximate zero-order up to 5.90 ± 0.37 h with a precision of 9.0% RSD (n ¼ 6). A linear correlation was found for the infusion profile and the fitting equation was Y ¼ 0.014X À 0.004 (r ¼ 0.998). A temperature change of 4 C was found to modify the flow rate by about 12.0%. In vivo results demonstrated that the present subcutaneous infusion device was similar to the commercial infusion pump, and it could bring a long and constant ampicillin plasma level with minimized fluctuations.

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Section: Influences Of Membrane Thicknessmentioning

confidence: 99%

The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive

Xie

Yang²,

Yang³

et al. 2014

Drug Delivery

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“…The rate of water ingress was dependent on the osmotic pressure of the core and the permeability of the coating: the thicker coating, the lower water permeability. According to studies of Ofori-Kwakye et al (Ofori-Kwakye & Fell, 2003) and Liu et al (Liu et al, 2000), the increase of coating level would result in the decrease of water imbibing through the membrane; thus, the rate of hydration of the drug layer decreased, which resulted in decrease of release rate of drugs.…”

Section: Influence Of Weight Gain Of Tablet On Drug Release Profilementioning

confidence: 99%

A novel subcutaneous infusion delivery system based on osmotic pump:in vitroandin vivoevaluation

Gong¹,

Danyu³

et al. 2013

Drug Delivery

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School of Pharmacy, Zhejiang University, Hangzhou, P.R. China AbstractAn economical, convenient portable drug delivery system combining osmotic pump with subcutaneous infusion was developed, which was composed of three primary components: water chamber, osmotic pump chamber and support base. Ceftriaxone sodium (CRO) was selected as the model drug and osmotic pump tablets were prepared. The influence of osmotic agents on drug release profiles was evaluated. As the adjustment made by the osmotic agents was limited, the compositions of semipermeable membrane were investigated to determine significant associations of factors based on orthogonal design. The in vitro release profiles of the optimum formulation achieved to the predetermined value (15 AE 3 min for the initial release time T i and 5.75 AE 0.25 h for the extent release time T e ). The pharmacokinetic profiles of this drug delivery system were evaluated in Beagle dogs. In vivo results demonstrated that the osmotic pump subcutaneous infusion administration was equivalent to intravenous injection administration in terms of bioavailability. Moreover, constant drug plasma levels with minimized fluctuations could be achieved with this osmotic pump subcutaneous infusion system, compared with intravenous injection.

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“…Many different systems have been developed based on the principle of osmotic pressure and some of these systems have reached the market. Elementary osmotic pump (EOP) [5][6][7], sandwiched osmotic tablet system (SOTS) [8], pushpull systems (PPOP) [9][10][11][12], controlled porosity osmotic pumps (CPOP) [13,14], tablet in tablet (TNT) cores [15], Asymmetric membrane capsule for osmotic drug delivery [12,16], osmotic systems made by swellable-core technology [17] and swellable elementary osmotic pump(SEOP) [18,19] can be noted.…”

Section: Introductionmentioning

confidence: 99%

Nano-suspension coating as a technique to modulate the drug release from controlled porosity osmotic pumps for a soluble agent

Bahari

Javadzadeh

Barzegar-Jalali

et al. 2017

Colloids and Surfaces B: Biointerfaces

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, Nanosuspension coating as a technique to modulate the drug release from controlled porosity osmotic pumps for a soluble agent, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2017.02.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  Hydrophilic pore formers in nano range was prepared using ball mill  Pore former concentration in the coating had crucial effect on coating integrity  Gelling agent concentration in the coating had crucial effect on coating integrity  Nanosuspension coating tackle the issue associated with conventional osmotic pump 2 Grasphical abstract AbstractIn controlled porosity osmotic pumps (CPOP), usually finding a single solvent with a capability to dissolve both film former (hydrophobic) and pore former (hydrophilic) is extremely challenging.Therefore, the aim of the present investigation was to tackle the issue associated with controlled porosity osmotic pump (CPOP) system using nano-suspension coating method. In the present study 4-Amino pyridine was used as a highly water soluble drug. In this method, a hydrophilic pore former (sucrose or mannitol) in nano range was suspended in polymeric coating solution using ball-mill. The performance of the prepared formulations was assessed in terms of D12h (cumulative release percent after 12 hours), Devzero (mean percent deviation of drug release from zero order kinetic), tL (lag time of the drug release) and RSQzero. The results revealed that gelling agent amount (HPMC E15LV) in core and pore former concentration in SPM had crucial effect on SPM integrity. All the optimised formulations showed a burst drug release due to fast dissolving nature of the pore formers. Results obtained from 3 scanning electron microscopy demonstrated the formation of nanopores in the membrane where the drug release takes place via these nanopores. Nano suspension coating method can be introduced as novel method in formulation of CPOPs.

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Nifedipine controlled delivery by sandwiched osmotic tablet system

Cited by 101 publications

References 9 publications

The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive

The development and evaluation of a subcutaneous infusion delivery system based on osmotic pump control and gas drive

A novel subcutaneous infusion delivery system based on osmotic pump:in vitroandin vivoevaluation

Nano-suspension coating as a technique to modulate the drug release from controlled porosity osmotic pumps for a soluble agent

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