Nifedipine Enhances the Cardioprotective Effect of an Angiotensin-II Receptor Blocker in an Experimental Animal Model of Heart Failure

Okuda, Naoki; Hayashi, Toshio; Mori, Tatsuhiko; Inamoto, Sakiko; Okabe, Makoto; Mieno, Shigetoshi; Horimoto, Hitoshi; Kitaura, Yasushi

doi:10.1291/hypres.28.431

Cited by 26 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27,48 In the present study, the plasma LPO level, a marker of systemic oxidative stress, was significantly increased in mice exposed to intermittent hypoxia. In addition, intermittent hypoxia significantly enhanced NADPH-dependent superoxide production and 4-HNE expression in the LV myocardium.…”

supporting

confidence: 54%

See 1 more Smart Citation

Chymase Plays an Important Role in Left Ventricular Remodeling Induced by Intermittent Hypoxia in Mice

Matsumoto

Hayashi²,

Kitada³

et al. 2009

Hypertension

Self Cite

View full text Add to dashboard Cite

Abstract-Intermittent hypoxia caused by sleep apnea is associated with cardiovascular disease. Chymase has been reported to play an important role in the development of cardiovascular disease, but it is unclear whether chymase is involved in the pathogenesis of left ventricular remodeling induced by intermittent hypoxia. The aim of this study was to evaluate the effect of a novel chymase inhibitor (NK3201) on hypoxia-induced left ventricular remodeling in mice. Male C57BL/6J mice (9 weeks old) were exposed to intermittent hypoxia or normoxia and were treated with NK3201 (10 mg/kg per day) or the vehicle for 10 days. Left ventricular systolic pressure showed no significant differences among all of the experimental groups. Exposure to intermittent hypoxia increased left ventricular chymase activity and angiotensin II expression, which were both suppressed by treatment with NK3201. Intermittent hypoxia also increased the mean cardiomyocyte diameter, perivascular fibrosis, expression of inflammatory cytokines, oxidative stress, and NADPH-dependent superoxide production in the left ventricular myocardium. These changes were all suppressed by NK3201 treatment. Therefore, chymase might play an important role in intermittent hypoxia-induced left ventricular remodeling, which is independent of the systemic blood pressure. (Hypertension. 2009;54:164-171.)

show abstract

supporting

confidence: 54%

“…23 The percentage area of 4-HNE and Ang II staining was measured by the method reported previously. 27 …”

Section: Immunohistochemistry For 4-hydroxy-2-nonenal and Ang IImentioning

confidence: 99%

Chymase Plays an Important Role in Left Ventricular Remodeling Induced by Intermittent Hypoxia in Mice

Matsumoto

Hayashi²,

Kitada³

et al. 2009

Hypertension

Self Cite

View full text Add to dashboard Cite

show abstract

“…Both intensity and area were analyzed by the method published previously. 17 The data from all the examined sections were used to calculate the % area of positive pixels relative to the total examined area in pixels.…”

Section: Immunohistochemistry For Hif-1 and Vegfmentioning

confidence: 99%

Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia

Inamoto

Hayashi

Tazawa

et al. 2006

Circ J

Self Cite

View full text Add to dashboard Cite

“…9) Hayashi, et al 10) also reported that a combination of ARB and nifedipine enhances this effect, and increases the myocardial capillary density. On the other hand, Komuro, et al 11) suggested that long-acting Ca antagonists may prevent cardiac hypertrophy by altering calcineurin activation due to Ca 2+ inflow into the myocardium during the onset and progression of cardiac hypertrophy.…”

Section: Discussionmentioning

confidence: 94%

Additive Antihypertensive and Antihypertrophic Effects of Long-Acting Ca Blockers in Uncontrolled Hypertensive Patients With Angiotensin-Receptor Blocker Based Treatment

et al. 2009

View full text Add to dashboard Cite

SummaryThe aim of the present study was to examine the antihypertensive and antihypertrophic effects of combined treatment with a long-acting calcium antagonist on top of an angiotensin II receptor blocker (ARB) in uncontrolled hypertensive patients. Patients with essential hypertension and a blood pressure > 140/90 mmHg on ARB monotherapy (losartan 50 mg/day or candesartan 8 mg/day) were randomly assigned to a nifedipine controlled release (CR) group (n = 15) or amlodipine group (n = 11). A significant additional antihypertensive effect was noted from 1 month with nifedipine and 2 months with amlodipine. The average daily dose was 25 mg for nifedipine and 5 mg for amlodipine. The cardiothoracic ratio was significantly reduced in both groups after 3 months. Left ventricular wall thickness and left ventricular mass index also decreased. Metabolic parameters, hepatic function, and renal function did not change significantly. Additional treatment with a longacting calcium antagonist achieved further blood pressure reduction as well as an antihypertrophic effect in the uncontrolled patients with prior ARB monotherapy. (Int Heart J 2009; 50: 555-570)

show abstract

Nifedipine Enhances the Cardioprotective Effect of an Angiotensin-II Receptor Blocker in an Experimental Animal Model of Heart Failure

Cited by 26 publications

References 36 publications

Chymase Plays an Important Role in Left Ventricular Remodeling Induced by Intermittent Hypoxia in Mice

Chymase Plays an Important Role in Left Ventricular Remodeling Induced by Intermittent Hypoxia in Mice

Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia

Additive Antihypertensive and Antihypertrophic Effects of Long-Acting Ca Blockers in Uncontrolled Hypertensive Patients With Angiotensin-Receptor Blocker Based Treatment

Contact Info

Product

Resources

About