Nifedipine Increases Urinary Excretion of Prostacyclin Metabolite in Hypertensive Pregnancy

Manninen, Auli; Metsä‐Ketelä, T.; Tuimala, Risto; Vapaatalo, Heikki

doi:10.1111/j.1600-0773.1991.tb00411.x

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…(50) Despite causing vasodilatation, these agents seldom cause a problematic tachycardia. Transient facial flushing, headaches and warm sweaty extremities seem to be the most common side effects.…”

Section: Autumn 2014mentioning

confidence: 99%

Treatment of hypertension during pregnancy

Hall

2017

SAHJ

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68eclampsia. Amongst these women, pulmonary oedema (28%), intracranial haemorrhage (23%), cerebral oedema resulting in coning (9%) and brain death following a hypoxic event (7%) were the most frequently recorded final causes of death. Although most of these deaths occurred in tertiary and regional hospitals, hypertensive deaths still comprised 15% of all maternal deaths at Community Health Centres, emphasising the importance of correct initial management at all levels of care.(6) With regards to the timing of the emergency event related to hypertension, 28% (n=191) occurred in the postpartum period. An important aspect of the Saving Mothers report is the attention paid by assessors to avoidable factors, missed opportunities and sub-standard care. In the most recent report, health worker orientated emergency management problems were noted in 42% of hypertensive deaths at Community Health Centres and District hospitals, 33% at Regional hospitals and 17% at Tertiary hospitals.(6) Not only is the mortality associated with hypertensive disorders in pregnancy high, but these conditions are a frequent source of significant morbidity. (8,9) Cases with Severe Acute Maternal Morbidity (SAMM) share many characteristics with maternal deaths. (10) Therefore understanding and managing SAMM also helps to decrease or prevent maternal mortality.

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Section: Autumn 2014mentioning

confidence: 99%

Treatment of hypertension during pregnancy

Hall

2017

SAHJ

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“…7 This class of drug became the preferred agent for control of hypertensive emergencies in pregnancy during the 1970's and 1980's. 13 Other drugs in its class have also been shown to reduce thromboxane-stimulated contraction in the uteroplacental arterial beds, 14 -15 thus having the capability of lowering maternal blood pressure without compromising placental function. 9 Nifedipine had previously been proven to be efficacious in the treatment of severe hypertension.…”

Section: Introductionmentioning

confidence: 99%